Journal
ARCHIVES OF MEDICAL SCIENCE
Volume 11, Issue 1, Pages 57-66Publisher
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/aoms.2015.49217
Keywords
lymphangiogenesis; platelet-derived growth factor receptor; platelet-derived growth factor; tumor microenvironment
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Funding
- UEFISCDI of the Romanian Ministry of Education and Research [345/2011, TE109/2011]
- Internal Grant from Victor Babes University of Medicine and Pharmacy Timisoara Romania [PIII-C1-CFI-2014/2015-02]
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Crosstalk between angiogenesis and lymphangiogenesis in embryonic development continues during postnatal life and has specific mechanisms involving factors that initiate activation of the intracellular cascade for their specific receptors. Platelet-derived growth factors (PDGFs) and their corresponding receptors (PDGFRs) are known as important regulators of blood vessel development in both normal and pathologic angiogenesis. Despite some recent papers which reported a potential role of the PDGF/PDGFR axis in lymphatic spread of tumor cells, a few papers have suggested the potential role of PDGFs in tumor lymphangiogenesis development. The present paper summarizes the potential lymphangiogenic role of the PDGF/PDGFR axis, underlying upcoming challenges in the field.
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