Article
Clinical Neurology
Alessandro Picelli, Mirko Filippetti, Lidia Del Piccolo, Federico Schena, Leonardo Chelazzi, Chiara Della Libera, Massimo Donadelli, Valeria Donisi, Paolo Francesco Fabene, Stefania Fochi, Cristina Fonte, Marialuisa Gandolfi, Macarena Gomez-Lira, Elena Locatelli, Giovanni Malerba, Sofia Mariotto, Chiara Milanese, Cristina Patuzzo, Maria Grazia Romanelli, Andrea Sbarbati, Stefano Tamburin, Massimo Venturelli, Paola Zamparo, Alessandra Carcereri de Prati, Elena Butturini, Valentina Varalta, Nicola Smania
Summary: The study protocol aims to investigate the effects of long-term neurorehabilitation on stroke patients and define a related profile of biomarkers. It will compare the long-term effects of intensive self-rehabilitation versus usual care for stroke patients. The trial will also explore the role of training intensity on long-term recovery after stroke and define a set of biomarkers related to post-stroke recovery and neurorehabilitation outcome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Christina Hamlet, Lisa Fauci, Jennifer R. Morgan, Eric D. Tytell
Summary: Spinal injuries can cause loss of locomotor ability in vertebrates. A study on lampreys suggests that amplifying sensory feedback can help restore swimming function even if the descending signal is lost, although the exact mechanism is still unknown.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Jesus Olivero-Verbel, Ana De La Parra-Guerra, Karina Caballero-Gallardo, Lucellys Sierra-Marquez, Katerin Fuentes-Lopez, Jackeline Franco-Marmolejo, Amber S. Jannasch, Maria S. Sepulveda, Elena Stashenko
Summary: The aqueous extract of fallen leaves from Fridericia chica has potential pharmacological properties in protecting Caenorhabditis elegans from ethoxylated nonylphenol-induced toxicity. The extract showed little lethality, improved reproductive capacity, and inhibited oxidative stress in the nematodes. The chemical analysis revealed the presence of molecules with antioxidant, metabolic, and immune modulator properties, making the extract a promising source of bioactive compounds for pharmacological purposes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Marine & Freshwater Biology
Yi Huang, Yuhang Hong, Hongmei Yin, Guangwen Yan, Qiang Huang, Zhiqiang Li, Zhiqiu Huang
Summary: The study found that IMI at environmentally realistic concentrations can cause AChE inhibition and oxidative stress in crayfish, leading to impaired locomotion. IMI also affects digestive functions by enzyme inhibition and dysbiosis of gut microbiota.
AQUATIC TOXICOLOGY
(2021)
Article
Marine & Freshwater Biology
Esther Hoyo-Alvarez, Pablo Arechavala-Lopez, Manuel Jimenez-Garcia, Antonia Solomando, Carmen Alomar, Antoni Sureda, David Moranta, Salud Deudero
Summary: This study investigates the effects of pollutants and microplastics ingestion on fish brains, specifically looking at oxidative stress biomarkers and monoaminergic neurotransmitters in gilthead seabream. The results show that a diet enriched with microplastics and pollutants increases oxidative stress biomarker activity and leads to changes in dopaminergic and serotonergic system activity in seabream brains. However, after a detoxification period, there is a tendency for enzymatic and neurotransmitter levels to recover.
AQUATIC TOXICOLOGY
(2022)
Article
Clinical Neurology
Xiong Lei, Zhixiao Xu, Wenwen Chen
Summary: Oxidative stress is correlated with sleep quality. Diet and lifestyle can influence sleep quality by modulating oxidative balance. Antioxidant diets and lifestyles are important in reducing sleep problems and improving sleep quality.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Organic
Yixin Jia, Jiaolong Meng, Deqing Hu, Hao Kang, Xuefeng Jiang
Summary: Aerobic oxidation of organoboron was achieved via uranyl photocatalysis using the principle of indirect single electron transfer. Multiple phenols and alcohols, including natural products and pharmaceuticals, were obtained under mild ambient conditions. The i-SET process between the uranyl catalyst and triethylamine was determined, and oxygen was confirmed to be derived from O-2 through O-18 labeling experiments.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Kadine Cabey, Dani M. Long, Alexander Law, Nora E. Gray, Christine McClure, Maya Caruso, Parnian Lak, Kirsten M. Wright, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath, Doris Kretzschmar
Summary: Due to the increasing aging population, age-related diseases and changes such as cognitive decline and sleep disturbances have become a growing health threat. This study suggests that oxidative stress may be behind many of these changes. The herbs Withania somnifera and Centella asiatica have shown potential in reducing oxidative stress and improving age-related impairments in behavior, indicating that they might promote healthy aging in humans.
Article
Pharmacology & Pharmacy
Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi
Summary: Fisetin has been found to improve cognitive function in mice with PTZ-induced kindling through modulation of oxidative stress markers, gene expressions, and neurotransmitter levels. These findings suggest a therapeutic potential of fisetin against cognitive dysfunction associated with PTZ-induced kindling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Song Xue, Tengqun Shen, Mengfan Li, Bing Leng, Ran Yao, Yanling Gao, Hairong Sun, Zhenguang Li, Jinbiao Zhang
Summary: Increasing evidence suggests a link between obstructive sleep apnea (OSA) and cognition, but the mechanism remains unclear. This study explored the relationship between glutamate transporters and cognitive impairment in OSA. The findings showed that OSA patients had higher levels of plasma neuron-derived exosomes (NDEs) excitatory amino acid transporter 2 (EAAT2) compared to healthy individuals, and higher EAAT2 levels were associated with cognitive impairment in OSA patients. After 1 year of continuous positive airway pressure (CPAP) treatment, EAAT2 levels decreased significantly and cognitive scores improved significantly.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Jonas Beck, Erna Loretz, Bjoern Rasch
Summary: The anticipation of stress affects sleep, with post-sleep stress reducing slow-wave sleep and sleep quality, while pre-sleep stress leads to a decrease in early sleep quality.
Article
Multidisciplinary Sciences
Nissim Arish, Gabriel Izbicki, Ariel Rokach, Amir Jarjou'i, George Kalak, Shmuel Goldberg
Summary: Patients with both COVID-19 and obstructive sleep apnoea (OSA) have worse outcomes. This study found that high OSA risk was associated with severe COVID-19 and longer hospitalization. The Berlin and ESS questionnaires should be completed for every COVID-19-infected patient, especially those with comorbidities.
Article
Environmental Sciences
Renan dos Santos Araujo, Thais Andrade Viana, Lorena Lisbetd Botina, Daniel Silva Sena Bastos, Beatriz Cristina da Silva Alves, Mariana Machado-Neves, Rodrigo Cupertino Bernardes, Gustavo Ferreira Martins
Summary: This study evaluated the effects of acute oral exposure to the herbicide Calaris(R) on honeybee foragers. The findings revealed significant harmful effects on honeybees, including decreased locomotor activity, damage to the midgut epithelium, reduced antioxidant enzyme activity, and decreased hemocyte count.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Qiaolifan Aerqin, Sha-Sha Jia, Xue-Ning Shen, Quan Li, Ke-Liang Chen, Ya-Nan Ou, Yu-Yuan Huang, Qiang Dong, Shu-Fen Chen, Jin-Tai Yu
Summary: This study found that decreased levels of serum UA were correlated with Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, frontotemporal dementia, and dementia with Lewy bodies. Additionally, serum UA levels were positively correlated with cognitive levels in all patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Oncology
Jiajia Du, Aoxue Zhang, Jing Li, Xin Liu, Shuai Wu, Bin Wang, Yanhong Wang, Hongyan Jia
Summary: Chemotherapy can prolong survival in breast cancer patients, but drugs like doxorubicin may cause cognitive deficits including learning, reasoning, attention, and memory impairments. The mechanisms behind this chemo-brain phenomenon are complex and interconnected, involving DNA damage, oxidative stress, inflammation, apoptosis dysregulation, neurotransmitter changes, mitochondrial dysfunction, glial cell interactions, neurogenesis inhibition, and epigenetic factors.
FRONTIERS IN ONCOLOGY
(2021)