Article
Radiology, Nuclear Medicine & Medical Imaging
Tom D. Turmezei, Samantha B. Low, Simon Rupret, Graham M. Treece, Andrew H. Gee, James W. MacKay, John A. Lynch, Kenneth E. S. Poole, Neil A. Segal
Summary: Joint space mapping (JSM) of the knee using weight-bearing CT images is reproducible and feasible, showing a relationship between three-dimensional joint space width distribution and structural joint disease. Novice users can learn it reliably, and it can achieve a smallest detectable difference that is at least 50% smaller than that reported in radiography.
Article
Biochemistry & Molecular Biology
Chenshuang Li, Zhong Zheng
Summary: OA affects people of all ages, sexes, and races, with a greater burden in women. Gender-specific OA management shows potential, and drug development should consider OA-responsive biomarkers. Genes from a transcriptome dataset are analyzed to identify key pathways influencing OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yvonne Rellmann, Elco Eidhof, Uwe Hansen, Lutz Fleischhauer, Jonas Vogel, Hauke Clausen-Schaumann, Attila Aszodi, Rita Dreier
Summary: Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum of chondrocytes, leading to the development of knee osteoarthritis. This study found that ER stress in chondrocytes results in the degeneration and apoptosis of knee cartilage, with young mice being less susceptible to OA. The findings suggest that inhibiting ER stress may be an attractive therapeutic target for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Chenyue Xu, Ziyue Mi, Zhenyue Dong, Xiaobo Chen, Gang Ji, Huijun Kang, Kehan Li, Bo Zhao, Fei Wang
Summary: The study found that platelet-derived exosomes can promote chondrocyte proliferation and migration, as well as alleviate cartilage degeneration, thereby slowing down the progression of osteoarthritis. The underlying mechanisms of platelet exosome treatment were revealed, including anti-inflammatory effects, promotion of cartilage repair, and inhibition of joint damage. This study has important implications for the development of new therapies for the prevention and treatment of osteoarthritis.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hailong Hu, Xiaopeng Song, Yue Li, Tianwen Ma, Hui Bai, Mingchao Zhao, Xinyu Wang, Lin Liu, Li Gao
Summary: The study showed that emodin effectively reduced the expression of MMP-3, MMP-13, ADAMTS-4, and iNOS in chondrocytes and cartilage, protected knee joint cartilage, and significantly decreased blood levels of COX-2 and PGE2. Emodin at 5 μmol/L was found to be the best concentration for treating chondrocytes, while emodin at 80 mg/kg had a protective effect comparable to Celecoxib.
Review
Cell & Tissue Engineering
Xiao-Na Xiang, Si-Yi Zhu, Hong-Chen He, Xi Yu, Yang Xu, Cheng-Qi He
Summary: Osteoarthritis is a common degenerative disease that causes high socioeconomic costs and disability rates. The knee joint is most commonly affected, characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and inflammation. MSC-based therapy has been explored as a new regenerative treatment for knee osteoarthritis. However, the detailed functions and mechanisms of MSC-based therapy, especially for cartilage regeneration, have not been explained.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Moon-Chang Choi, Jiwon Jo, Myeongjin Lee, Jonggwan Park, Yoonkyung Park
Summary: The study found that the antimicrobial peptide Cramp induces chondrocyte catabolism via the NF-kappa B signaling pathway, accelerating the progression of OA and leading to cartilage degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
M. Jarraya, A. Guermazi, J. W. Liew, I. Tolstykh, J. A. Lynch, P. Aliabadi, D. T. Felson, M. Clancy, M. Nevitt, C. E. Lewis, J. Torner, T. Neogi
Summary: The aim of this study was to report the prevalence of CT-detected intra-articular mineralization. It was found that 9.8% of knees had intra-articular mineralization based on CT imaging. Mineralization predominantly occurred in the three compartments of the joint, especially the patellofemoral compartment.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Multidisciplinary Sciences
Vicente J. Leon-Munoz, Silvio Manca, Mirian Lopez-Lopez, Francisco Martinez-Martinez, Fernando Santonja-Medina
Summary: The study found a linear relationship between coronal alignment and the rotational geometry of the distal femur, with no correlation between global coronal alignment and femoral version. This suggests that addressing lower extremity deformities may improve outcomes of total knee arthroplasty surgery.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Nirav Maniar, Evert Verhagen, Adam Leigh Bryant, David Andrew Opar
Summary: This study analyzed epidemiological data on knee injuries in Australia over a 20-year period, revealing increasing annual incidence rates and a particularly rapid rise in ACL injuries among females aged 5-14. Urgent intervention is needed to address these trends.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Rheumatology
Dong Jin Go, Dong Hyun Kim, Jie Young Kim, Ali Guermazi, Michel Daoud Crema, David J. Hunter, Hyun Ah Kim
Summary: In elderly community residents without gout, serum UA levels were not associated with knee OA progression but were negatively associated with patellofemoral cartilage loss over time. Further large-scale longitudinal studies are needed to confirm the relationship between UA and cartilage damage in different populations.
Review
Biochemistry & Molecular Biology
Pengxu Wei, Ruixue Bao
Summary: Knee osteoarthritis is a common problem, especially in older individuals, and can eventually lead to disability. Injecting mesenchymal stem cells (MSCs) into the knee joint has been shown to induce cartilage regeneration in several studies. Additionally, understanding the anatomical, biomechanical, and biochemical changes associated with knee osteoarthritis can help develop appropriate interventions to delay disease progression and improve cartilage repair induced by MSC injection. Post-injection rehabilitation programs and related mechanisms are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Yuanyuan Wang, Tao Meng, Guangfeng Ruan, Shuang Zheng, Jimin Zhu, Han Cen, Benny Antony, Anita E. Wluka, Flavia Cicuttini, Tania Winzenberg, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Changhai Ding
Summary: The study found that blood pressure and arterial stiffness are associated with knee cartilage volume in patients with knee OA, supporting the involvement of blood pressure and arterial stiffness in the progression of knee OA.
Review
Biochemistry & Molecular Biology
Jorden Xavier, William Jerome, Kenneth Zaslav, Daniel Grande
Summary: This review examines the use of exosome-scaffold therapeutics for post-traumatic cartilage injury and osteoarthritis treatment. In vivo studies show that scaffold designs with MSC-based exosomes have unique properties and can reduce inflammation and induce tissue regeneration. However, further research is needed to determine long-term biocompatibility and optimize scaffold designs for human treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Biomedical
Xiao Xu, Limei Xu, Jiang Xia, Caining Wen, Yujie Liang, Yuanmin Zhang
Summary: Osteoarthritis (OA) is a common disease characterized by cartilage degeneration in middle-aged and elderly people. Currently, there is no effective treatment for OA apart from total joint replacement in advanced stages. Mesenchymal stem cells (MSCs) have shown great potential in regulating the cartilage microenvironment, promoting cartilage regeneration, and alleviating OA symptoms, making them a promising source of cells for OA therapy.
ACTA BIOMATERIALIA
(2023)
Article
Medicine, General & Internal
Ishanka P. Munugoda, Sharon L. Brennan-Olsen, Karen Wills, Guoqi Cai, Stephen E. Graves, Michelle Lorimer, Flavia M. Cicuttini, Michele L. Callisaya, Dawn Aitken, Graeme Jones
Summary: This study explores the relationship between socioeconomic status (SES) and time to total hip replacements (THR) and total knee replacements (TKR). The findings suggest that participants with a higher SES had a longer time to THR compared to those with a lower SES. However, this association may be mediated by factors such as pain and radiographic osteoarthritis.
INTERNAL MEDICINE JOURNAL
(2022)
Review
Orthopedics
Mahnuma Mahfuz Estee, Flavia M. Cicuttini, Matthew J. Page, Anant D. Butala, Anita E. Wluka, Sultana Monira Hussain, Yuanyuan Wang
Summary: Oral corticosteroids show medium effect on pain relief, stiffness improvement, and functional improvement at 4-6 weeks, but no persistent effect at 3 months after discontinuation. Intra-articular corticosteroids have no significant effect on pain or function. The role of corticosteroids in hand osteoarthritis is limited.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Rheumatology
Yuanyuan Wang, Ega Wirayoda Pontoh, Sultana Monira Hussain, Yuan Z. Lim, Graeme Jones, Catherine L. Hill, Anita E. Wluka, Andrew Tonkin, Changhai Ding, Flavia M. Cicuttini
Summary: This study found evidence for the involvement of vascular pathology in the progression of knee osteoarthritis and suggested that targeting atherosclerosis could improve outcomes in knee osteoarthritis.
Article
Rheumatology
Zetao Liao, Jun Chang, Zhaohua Zhu, Weiyu Han, Tao Meng, Shuang Zheng, Liudan Tu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding
Summary: The study examined the associations between dietary vitamin K intake and changes in knee symptoms and structures in patients with knee osteoarthritis (OA). The results showed that higher vitamin K intake was associated with a decrease in knee symptoms over 24 months. However, there was no overall association between vitamin K intake and changes in MRI features.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Guoqi Cai, Laura L. Laslett, Michael A. Bowes, Philip G. Conaghan, Flavia Cicuttini, Anita E. Wluka, Lyn March, Catherine Hill, Tania Winzenberg, Graeme Jones, Dawn Aitken
Summary: This study evaluated the effect of annual infusions of zoledronic acid with or without methylprednisolone on bone area and bone shape in knee osteoarthritis patients. The results showed that zoledronic acid combined with methylprednisolone can slow down the expansion of bone area, but zoledronic acid alone may not have the same effect. However, neither zoledronic acid with or without methylprednisolone slowed the progression of bone shape.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Medicine, Research & Experimental
Guoqi Cai, Graeme Jones, Flavia M. Cicuttini, Anita E. Wluka, Yuanyuan Wang, Catherine Hill, Helen Keen, Benny Antony, Xia Wang, Barbara de Graaff, Michael Thompson, Tania Winzenberg, Kathy Buttigieg, Dawn Aitken
Summary: This study aims to evaluate the effectiveness of diacerein in knee osteoarthritis patients with effusion-synovitis, and provide high-quality evidence. The results may have significant benefits for patients with an inflammatory phenotype.
Article
Orthopedics
S. M. Hussain, I. N. Ackerman, Y. Wang, D. R. English, A. E. Wluka, G. G. Giles, F. M. Cicuttini
Summary: The study aims to investigate the association between body mass index (BMI) trajectories from early adulthood to late midlife and the risk of total knee arthroplasty (TKA) for osteoarthritis. The results suggest that weight gain increases the risk of TKA, and weight reduction may play a significant role in preventing TKA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Orthopedics
P. Solanki, S. M. Hussain, J. Abidi, J. Cheng, J. L. Fairley, M. J. Page, F. M. Cicuttini, A. E. Wluka
Summary: This study conducted a systematic review and data synthesis, showing that weight gain in adults is associated with increased clinical and structural KOA and TKR. Preventing weight gain should be considered to improve outcomes in KOA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Rheumatology
Hylton B. B. Menz, Jamie J. J. Allan, Andrew K. K. Buldt, Karl B. B. Landorf, Flavia M. M. Cicuttini, Edward Roddy, Shannon E. E. Munteanu
Summary: This study aimed to determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). By comparing pain questionnaire results and related factors, the study found that a significant proportion of individuals with first MTP joint OA experience neuropathic pain, which may partly explain the suboptimal responses to commonly used treatments. Screening for neuropathic pain may be useful in selecting targeted interventions and improving clinical outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Medicine, General & Internal
Nicholas Woodland, Antony Takla, Mahnuma Mahfuz Estee, Angus Franks, Mansi Bhurani, Susan Liew, Flavia M. Cicuttini, Yuanyuan Wang
Summary: This systematic review evaluated the patient-reported outcomes following total knee replacement in individuals aged 65 years and older. The study found that TKR can reduce pain, improve function, and increase the quality of life for older individuals. Patients generally reported overall satisfaction with the results of the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Hylton B. Menz, Polly Q. X. Lim, Sheree E. Hurn, Karen J. Mickle, Andrew K. Buldt, Matthew P. Cotchett, Edward Roddy, Anita E. Wluka, Bircan Erbas, Mehak Batra, Shannon E. Munteanu
Summary: This study aimed to evaluate the effectiveness of a nonsurgical intervention for reducing pain associated with hallux valgus and determine the feasibility of conducting a randomized trial. The results showed that the current intervention is not feasible, primarily due to low adherence and the impact of COVID-19.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2023)
Article
Rheumatology
Mahnuma M. Estee, Yuanyuan Wang, Stephane Heritier, Donna M. Urquhart, Flavia M. Cicuttini, Mark A. Kotowicz, Sharon L. Brennan-Olsen, Julie A. Pasco, Anita E. Wluka
Summary: A study conducted on men over a 10-year period found that negative beliefs regarding back pain were associated with an increased likelihood of developing high-intensity pain and/or high disability.
Meeting Abstract
Medicine, General & Internal
Yuan Lim, Flavia Cicuttini, Anita Wluka, Graeme Jones, Catherine Hill, Andrew Forbes, Andrew Tonkin, Sofia Berezovskaya, Lynn Tan, Changhai Ding, Yuanyuan Wang
INTERNAL MEDICINE JOURNAL
(2022)
Meeting Abstract
Orthopedics
Y. Wang, A. Owen, A. Franks, I. Ackerman, S. Fitzgerald, S. Liew, R. Woods, A. Wluka, J. McNeil, F. Cicuttini
OSTEOARTHRITIS AND CARTILAGE
(2022)
Meeting Abstract
Orthopedics
S. Hussain, Y. Wang, D. R. English, A. E. Wluka, G. G. Giles, S. E. Graves, F. M. Cicuttini
OSTEOARTHRITIS AND CARTILAGE
(2022)