Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan
Summary: Biological augmentation techniques have potential in ACL reconstruction, but clinical studies are currently lacking concrete evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Clemens Goegele, Judith Hahn, Gundula Schulze-Tanzil
Summary: The firm integration of anterior cruciate ligament (ACL) grafts into bones remains a challenging issue in ACL reconstruction. To achieve a functional-tissue-engineered ACL substitute, robust bone attachment sites need to be re-established. This review discusses the peculiarities of synovioentheseal complexes at the femoral and tibial attachment sites and explores tissue engineering strategies to address them. Various material composites and manufacturing techniques have been applied to mimic the ACL enthesis tissue gradients, and functionalized materials and growth factors have been integrated for zone-dependent differentiation of precursor cells. However, the individual and asymmetric histoarchitectures of ACL entheses present a unique biomechanical microenvironment that must be considered in future ACL interface tissue engineering approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Sandra Camarero-Espinosa, Huipin Yuan, Pieter J. Emans, Lorenzo Moroni
Summary: The anterior cruciate ligament (ACL) is essential for knee joint stability, but reconstruction after rupture remains challenging. This study proposes a tri-phasic fibrous scaffold that mimics the structure of native ACL, with promising mechanical properties and cell organization. In vivo implantation in rabbits demonstrates superior performance compared to traditional aligned scaffolds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Agriculture, Dairy & Animal Science
Gert W. Niebauer, Brunella Restucci
Summary: The spontaneous rupture of the cranial cruciate ligament in dogs is a common veterinary orthopedic problem. The causes of this disease are largely unknown, making prevention and treatment challenging. Recent research has revealed a systemic, metabolic multifactorial disease background behind the disease, and it also showed an association between this disease in dogs and humans. Therefore, unraveling the enigma of spontaneous cruciate ligament disease is of great importance for the treatment of degenerative joint disease in both dogs and humans.
Article
Genetics & Heredity
Lauren A. Baker, Mehdi Momen, Rachel McNally, Mark E. Berres, Emily E. Binversie, Susannah J. Sample, Peter Muir
Summary: ACL rupture is a common condition that affects young people, with genetic and environmental risk factors. Leveraging a canine model, researchers identified novel genetic variants associated with ACL rupture and found unique selection signatures in cases compared to controls. The study's genetic associations mirror those found in human beings, laying the groundwork for potential disease-modifying therapies.
FRONTIERS IN GENETICS
(2021)
Review
Sport Sciences
Nirav Maniar, Michael H. Cole, Adam L. Bryant, David A. Opar
Summary: This review investigated the relationship between muscle force and ACL loading, revealing that the quadriceps and gastrocnemius increase ACL load, while the hamstrings, soleus, and gluteus medius unload the ACL. Limited evidence was found for other muscle groups. Interventions aiming to reduce ACL injury risk should focus on the function of the hamstrings, soleus, and gluteus medius.
Editorial Material
Orthopedics
Clayton W. Nuelle, B. Christian Balldin, Harris S. Slone
Summary: ACL reconstruction using the all-inside technique is a commonly performed knee operation. It offers several advantages, including anatomical tunnel placement, decreased postoperative pain and swelling, minimal hardware, appropriate tensioning of the graft, and successful graft to bone healing. Studies have shown that it has similar or superior biomechanical properties and clinical outcomes compared to traditional full-tunnel ACL reconstruction techniques.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Megan N. N. Ashton, Asha E. E. Worsham, Matthew D. D. Strawn, Geoffrey D. D. Fisher, Cody J. J. Perry, Matthew P. P. Ferguson, Mimi Zumwalt, George W. W. Brindley, Javad Hashemi, Hossein Mansouri, James R. R. Slauterbeck, Daniel M. M. Hardy
Summary: Correlating gene expression patterns with biomechanical properties of connective tissues provides insights into the molecular processes underlying the tissue growth and repair. Despite the limitations caused by nuclease-mediated RNA degradation, valid gene expression profiles can still be obtained using degraded RNA from human anterior cruciate ligaments (ACLs). The levels of gene expression in degraded RNA showed strong correlation with non-degraded RNA, and legitimate quantitative comparisons between variably degraded tissues can be made by normalizing data to appropriate housekeeping transcripts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jie-Ting Li, Ni Zeng, Zhi-Peng Yan, Tao Liao, Xin Chen, Guo-Xin Ni
Summary: The metabolic changes in rat serum after an ACL injury were closely related to disturbances in energy metabolism and amino acid metabolism, which may contribute to the pathogenesis of posttraumatic osteoarthritis.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Lanxin Yang, Chengyu Li, Wenhao Lu, Jie An, Di Liu, Jianzhe Luo, Yusheng Li, Zhong Lin Wang, Wei Tang, Bo Meng
Summary: Presented a wearable displacement sensing system for diagnosing ACL injuries. The system measures the displacement difference between the affected leg and the healthy leg during the Lachman test to determine the risk of ACL injury. Compared with arthroscopy, the wearable system has a higher consistency rate and shows the feasibility of becoming a convenient method for diagnosing ACL injuries.
Article
Engineering, Biomedical
Jiangyu Cai, Qianqian Zhang, Jiebo Chen, Jia Jiang, Xiumei Mo, Chuanglong He, Jinzhong Zhao
Summary: The study evaluated the effects of biomineralization and electrodeposition methods for depositing calcium-phosphate on PET artificial ligaments. Results showed that ED-CaP had more uniform particles and element distribution, enhancing osteogenic differentiation of cells and graft-bone integration. Overall, electrodeposition of CaP is an effective strategy to modify PET artificial ligaments and improve graft-bone integration both in vitro and in vivo.
BIOACTIVE MATERIALS
(2021)
Article
Orthopedics
Clemens Gwinner, Milan Janosec, Guido Wierer, Michael Wagner, Andreas Weiler
Summary: The study revealed a significant correlation between increased tibial slope and early and repeated graft insufficiency after ACL reconstruction, with patients having a tibial slope greater than or equal to 12 degrees having a higher risk of repeated ACL graft insufficiency.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Polymer Science
Aminatun, Rifqha Huriah, Dyah Hikmawati, Sofijan Hadi, Tahta Amrillah, Che Azurahanim Che Abdullah
Summary: This study aims to investigate the effect of composition variations in polylactic acid (PLA) and polycaprolactone (PCL) on ACL scaffold performance. The results demonstrate that PLA-PCL 80:20 (wt%) shows the best performance, including smaller fiber diameter, higher cell viability percentage, and longer degradation time.
Article
Orthopedics
Nicolas Pascual-Leone, Preston W. Gross, Blake C. Meza, Peter D. Fabricant
Summary: In recent years, there has been an increase in the frequency of anterior cruciate ligament (ACL) tears and reconstructions in skeletally immature patients. The surgical technique and graft selection are crucial to minimize iatrogenic physeal injury.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Medicine, General & Internal
Francesco Bosco, Fortunato Giustra, Alessandro Ghirri, Giorgio Cacciola, Alessandro Masse, Marcello Capella
Summary: The all-inside anterior cruciate ligament reconstruction (ACLR) technique aims to improve patient outcomes and postoperative recovery, and can be applied to all ACL injury patients. Literature reports the advantages and good clinical outcomes of this technique, but the associated complications and disadvantages should be considered.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Veterinary Sciences
Masataka Enomoto, Patrick W. Mantyh, Joanna Murrell, John F. Innes, B. Duncan X. Lascelles
Article
Veterinary Sciences
Jessica McCarthy, Eithne J. Comerford, John F. Innes, Rob A. Pettitt
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2020)
Article
Veterinary Sciences
S. Garcia-Pertierra, J. Ryan, J. Richardson, B. Koterwas, E. Keeble, K. Eatwell, D. N. Clementso
JOURNAL OF SMALL ANIMAL PRACTICE
(2020)
Article
Multidisciplinary Sciences
Charlotte S. C. Woolley, Ian G. Handel, B. Mark Bronsvoort, Jeffrey J. Schoenebeck, Dylan N. Clements
Article
Veterinary Sciences
E. Henderson, D. N. Clements, C. Johnson
VETERINARY RESEARCH COMMUNICATIONS
(2020)
Article
Veterinary Sciences
M. B. Walton, E. Crystal, S. Morrison, J. Onyett, J. McClement, R. Allan, M. Straw, J. F. Innes
JOURNAL OF SMALL ANIMAL PRACTICE
(2020)
Letter
Veterinary Sciences
M. Lowrie, M. Morton, B. Walton, J. Innes
JOURNAL OF SMALL ANIMAL PRACTICE
(2020)
Article
Veterinary Sciences
Thomas Cox, Thomas W. Maddox, Robert Pettitt, Brandan Wustefeld-Janssens, John Innes, Eithne Comerford
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2020)
Article
Veterinary Sciences
Joanna McCagherty, Maurizio Longo, Catrina Pennington, Tiziana Liuti, Linda R. Morrison, Helen Brown, Dylan Neil Clements
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ibtesam R. T. Al Delfi, Chelsea R. Wood, Louis D. V. Johnson, Martyn D. Snow, John F. Innes, Peter Myint, William E. B. Johnson
Article
Veterinary Sciences
Siti M. Zainal Ariffin, David Bennett, William R. Ferrell, John C. Lockhart, Lynette Dunning, Dylan N. Clements, B. Duncan X. Lascelles, Tengku A. Tengku Ibrahim, Pamela Johnston
Summary: The study aimed to determine the presence of PAR2 and matriptase proteins and quantify their mRNA expression in cats' articular tissues with and without OA. Results showed that PAR2 and matriptase proteins were present in all samples, with higher mRNA expression levels in OA articular cartilage compared to normal samples. Further research on PAR2 and matriptase pathobiology may lead to the development of novel therapeutic strategies for feline OA.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2021)
Article
Veterinary Sciences
Charlotte S. C. Woolley, Ian G. Handel, Barend M. Bronsvoort, Jeffrey J. Schoenebeck, Dylan N. Clements
Summary: This study confirmed an outbreak of vomiting in UK dogs between December 2019 and March 2020 using data from Dogslife and Google Trends. The odds of reporting a vomiting incident to Dogslife were 1.51 compared to previous years, indicating differences in owner decision-making when seeking veterinary attention and identifying factors associated with dogs at higher odds of experiencing a vomiting episode.
Article
Veterinary Sciences
C. Dorlis, S. Garcia-Pertierra, J. Richardson, B. Koterwas, E. Keeble, K. Eatwell, J. Ryan, D. N. Clements
Summary: Neutered continental giant rabbits aged 10 to 30 months presented with femoral condylar fractures were successfully treated with screw fixation, with complications in two cases resulting in one rabbit undergoing amputation. Recovery of normal limb function was reported in three cases.
JOURNAL OF SMALL ANIMAL PRACTICE
(2022)
Article
Multidisciplinary Sciences
John F. Innes, Mark A. Morton, B. Duncan X. Lascelles
Summary: The 'Liverpool Osteoarthritis in Dogs' (LOAD) and the 'Canine Orthopedic Index' (COI) have been validated for evaluating canine osteoarthritis, but the minimal clinically-important differences (MCIDs) for these measures have not been investigated. This study provided estimates for the MCIDs of LOAD and COI, which will aid in sample size estimates for future clinical trials using these measures.
Article
Veterinary Sciences
A. Trivino, C. Davidson, D. N. Clements, J. M. Ryan
Summary: The study evaluated the sit to stand test for identifying unilateral cranial cruciate ligament rupture in dogs. The findings showed that the test had good sensitivity in discriminating lame and non-lame dogs based on the symmetry indices of peak vertical force and vertical impulse. However, it had limited clinical utility in its tested form.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
