Article
Biochemistry & Molecular Biology
Cheuk-Chun Szeto, Ho So, Peter Yam-Kau Poon, Cathy Choi-Wan Luk, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Fernand Mac-Moune Lai, Lai-Shan Tam
Summary: Through the study of three cohorts of lupus nephritis patients and controls, we identified specific lncRNA targets in urine that are associated with the severity and histological classification of lupus nephritis. These urinary lncRNA levels may serve as biomarkers for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Rong Dai, Lei Zhang, Hua Jin, Dong Wang, Meng Cheng, Yunhui Xu, Haiyin Zhang, Yiping Wang
Summary: This study investigates the differential expression profile of urinary exosomal microRNAs (miRNAs) in patients with mesangial proliferative glomerulonephritis (MsPGN) and healthy controls using high-throughput sequencing technology. Validation with quantitative real-time polymerase chain reaction (qRT-PCR) confirmed the differential expression of five miRNAs in MsPGN patients. These miRNAs were associated with clinical features and could distinguish MsPGN patients from controls. The findings suggest that urinary exosomal miRNA expression may be a potential indicator of MsPGN and contribute to the understanding of the disease's pathophysiology at the epigenetic level.
Article
Urology & Nephrology
Javier Villacorta, Laura Lucientes, Elena Goicoechea, Mercedes Acevedo, Teresa Cavero, Luis Sanchez-Camara, Francisco Diaz-Crespo, Sara Gimenez-Moyano, Laura Garcia-Bermejo, Gema Fernandez-Juarez
Summary: Urinary soluble CD163 (usCD163) is an accurate biomarker for detecting active renal vasculitis and relapse, closely associated with disease activity, providing additional information for monitoring treatment response.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Medical Laboratory Technology
Cheuk-Chun Szeto, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Cathy Choi-Wan Luk, Ka-Bik Lai, Gang Wang, Kai-Ming Chow, Fernand Mac-Moune Lai
Summary: This study identified 6 miRNA targets that are significantly elevated in the urine of patients with IgAN, and urinary miR-106a level has excellent sensitivity for the diagnosis of IgAN. Further validation studies are needed to confirm its role in disease screening.
CLINICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Tingting Shi, Asahiro Morishita, Hideki Kobara, Tsutomu Masaki
Summary: miRNAs play crucial roles in the pathogenesis of cholangiocarcinoma, their potential as biomarkers for diagnosis and prognosis, and their utilization as novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Viktoria Wagner, Fabian Kern, Oliver Hahn, Nicholas Schaum, Nicole Ludwig, Tobias Fehlmann, Annika Engel, Dominic Henn, Shusruto Rishik, Alina Isakova, Michelle Tan, Rene Sit, Norma Neff, Martin Hart, Eckart Meese, Steve Quake, Tony Wyss-Coray, Andreas Keller
Summary: By studying the expression of noncoding RNA (ncRNA) in aging and rejuvenated mice, we found that the molecular aging trajectories are mostly tissue-specific, except for eight broadly deregulated microRNAs (miRNAs). These miRNAs were also found in circulating plasma and extracellular vesicles (EVs), while tissue-specific ncRNAs were less present. MiR-29c-3p had the strongest correlation with aging in solid organs, plasma, and EVs. In mice rejuvenated by heterochronic parabiosis, the level of miR-29c-3p was restored to a similar level as in young liver. MiR-29c-3p targets pathways related to the extracellular matrix and secretion, which are known to be involved in aging.
NATURE BIOTECHNOLOGY
(2023)
Article
Critical Care Medicine
Thanawat Phulkerd, Tanat Lertussavavivat, Umaporn Limothai, Sadudee Peerapornratana, Win Kulvichit, Nuttha Lumlertgul, Kriang Tungsanga, Somchai Eiam-Ong, Yingyos Avihingsanon, Nattachai Srisawat
Summary: This study discovered that the microtranscriptome profiles of severe AKI patients with renal recovery were different from those of the non-recovery group. Urine miR-556-3p had the potential to improve the prediction of renal recovery from severe AKI.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Transplantation
Haresh Selvaskandan, Izabella Pawluczyk, Jonathan Barratt
Summary: RNA interference (RNAi) is a widely present and important regulatory process in all organisms, modulating gene transcription and post-transcriptional processing. microRNAs (miRNAs) can regulate multiple genes within a cell, and multiple miRNAs can regulate expression of the same gene, adding complexity to gene expression regulation. miRNAs and other RNAi approaches have been used for basic science research and targeted therapeutics. This review focuses on the potential of miRNAs as biomarkers and novel therapeutics for glomerular disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Ahyoung Lee, Jiwon Moon, Jin Yu, Changwon Kho
Summary: This review discusses the clinical significance of microRNAs as potential biomarkers and therapeutic targets for DMD and DMD cardiomyopathy as examples of dystrophinopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, with up to 50% of patients experiencing depressive disorders. Major depression (MD) is a serious comorbidity of MS, potentially involving various dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Soudeh Ghafouri-Fard, Hamed Shoorei, Mahdi Mohaqiq, Jamal Majidpoor, Mohammad Amin Mossavi, Mohammad Taheri
Summary: Autophagy is a crucial self-degradative mechanism in cells, playing a key role in cell development and energy homeostasis, regulated by ATG proteins and influenced by lncRNAs and miRNAs. The roles of these regulatory factors in various disease contexts are significant and warrant further investigation.
Article
Biotechnology & Applied Microbiology
Nan Zhang, Jianfeng Wang, Shigeng Zhang, Huifeng Wu, Zhongyi Li, Maolin Hu
Summary: By analyzing urine samples from 83 prostate cancer patients and 88 healthy control subjects, we identified a panel of miRNA urinary biomarkers for early detection of prostate cancer. Furthermore, we optimized the panel and found a 6-miRNA biomarker panel that showed promising detection performance in the Chinese population.
Article
Endocrinology & Metabolism
Kristina Snipaitiene, Arnas Bakavicius, Juozas R. Lazutka, Albertas Ulys, Feliksas Jankevicius, Sonata Jarmalaite
Summary: Urinary miRNAs can serve as prognostic biomarkers for CRPC patients to predict response to AA therapy, especially in cases with high blood AR levels. Combining miR-429 with high AR levels predicts PFS, while combining miR-148a with AR levels predicts OS effectively.
Article
Chemistry, Multidisciplinary
Thakshila Liyanage, Bayan Alharbi, Linh Quan, Aurora Esquela-Kerscher, Gymama Slaughter
Summary: A tapered optical fiber plasmonic biosensor was developed for the sensitive detection of a panel of microRNAs in human serum. This biosensor showed high sensitivity and selectivity, enabling cancer diagnosis without the need for RNA extraction or sample amplification. Statistical studies demonstrated its reliable ability to differentiate cancerous and noncancerous samples.
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Parkinson's disease (PD) and Diabetes Mellitus (DM) have been shown to have a connection in recent studies. This link has been discussed in the literature in relation to different mechanisms. miRNAs play a crucial role in regulating insulin pathways, glucose absorption, and PD-related genes, making them a potential therapeutic target for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)