Review
Biochemical Research Methods
Emilia Neuwirt, Oliver Gorka, Benedikt S. Saller, Christina J. Gross, Tobias Madl, Olaf Gross
Summary: The review discusses the importance of NLRP3 inflammasome in innate immunity and pathogenic inflammation, as well as the current knowledge on its mechanisms in sensing endogenous danger signals.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Review
Immunology
Hongxu Xian, Michael Karin
Summary: Research has found that oxidized mitochondrial DNA (Ox-mtDNA) in myeloid cells activates the NLRP3 inflammasome, leading to the production of pro-inflammatory cytokines and interferons. In addition, Ox-mtDNA can be released into circulation through gasdermin D pores. Furthermore, Ox-mtDNA can convert transient inflammation into long-term immunopathology and serve as a biomarker for autoimmune diseases.
TRENDS IN IMMUNOLOGY
(2023)
Editorial Material
Health Care Sciences & Services
Paul Vermilion
Summary: This essay examines the issue of physician burnout in healthcare systems and criticizes the current approach of placing individual responsibility on solving the problem. Drawing parallels with the petrochemical industry, it suggests using systematic efforts to push back against the industry as a model for future wellness initiatives.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Elena Negrea-Busuioc
Summary: This paper examines the metaphors used by science communicators to explain the workings of COVID-19 vaccines on social media. One metaphor, 'vaccine as a cheat sheet', is given special attention. The author argues that while this metaphor clarifies vaccine-related information and mocks those susceptible to false information, it also has the potential to amplify vaccine-related polarization.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Immunology
Saikat Majumder, Mandy J. McGeachy
Summary: The IL-17 family is an evolutionarily old cytokine family with six members, with IL-17A receiving the most attention for its proinflammatory roles in autoimmune diseases. IL-17 is associated with a wide array of diseases, with surprisingly variable pathologies. Recent advances in understanding the roles of IL-17 in health and disease pathogenesis focus on how its beneficial functions can be diverted towards amplification of deleterious pathways driving chronic diseases.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Business
Ethiopia L. Segaro, Kajsa Haag
Summary: This article critically examines the role of government intervention in achieving sustainable local prosperity in developing countries' frontier markets, using a case study of the leather and leather products industry in Ethiopia. The findings highlight the unintended outcomes of government interventions due to power asymmetry and lack of institutional trust, which hinder the achievement of sustainable development goals.
JOURNAL OF BUSINESS ETHICS
(2022)
Review
Immunology
Jurgen Wittmann
Summary: Artificial intelligence (AI) has made significant progress, with the introduction of ChatGPT as the latest chatbot. To examine its potential in scientific writing, I tested ChatGPT's ability in creating an immunological review article on small RNAs during murine B cell development. Despite its polished and convincing language, ChatGPT struggled with details, references, and produced numerous incorrect statements. Consequently, I concluded that this type of AI is not (yet?) suitable for assisting in the writing of scientific articles.
IMMUNOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Costanza Montagna, Giuseppe Filomeni
Summary: This article aims to explore the possible role of S-nitrosylation/denitrosylation signaling in rhabdomyosarcoma, a common pediatric mesenchymal malignancy, by providing and linking different lines of evidence.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Dermatology
Steven D. Rhodes, Frank McCormick, Ross L. Cagan, Annette Bakker, Verena Staedtke, Ina Ly, Matthew R. Steensma, Sang Y. Lee, Carlos G. Romo, Jaishri O. Blakeley, Kavita Y. Sarin
Summary: Cutaneous neurofibromas (cNFs) are the most common tumors in neurofibromatosis type 1 patients, and there is a lack of effective interventions for their treatment. To develop new therapies, it is essential to understand the biology of cNFs, including the role of RAS signaling and downstream pathways. This review provides an overview of the current knowledge on RAS signaling in cNF pathogenesis and therapeutic development.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Sophia Tessema, Abdullahi E. Mahgoub, Rasha Nakhleh
Summary: Gout is a well-known type of arthritis with a prevalence of 1%-3% in the western world. Despite being well understood, there is increasing evidence of misdiagnosis of gout as other forms of arthritis, leading to delays in accurate diagnosis.
CLINICAL CASE REPORTS
(2021)
Article
Social Sciences, Interdisciplinary
Peter Clement Lund
Summary: This article discusses the implementation issues of Prolonged Grief Disorder in a Danish context, with the author utilizing "gonzo sociology" in their fieldwork. The narrative structure of the article highlights the author's journey in grief research, showing the intertwined nature of research methods, theory, and outcomes. Gonzo research aims to push boundaries in research through active participation and co-creation of discoveries, leading to a unique blend of journalistic, academic, and autoethnographic elements in the article.
INTERNATIONAL JOURNAL OF QUALITATIVE METHODS
(2021)
Article
Public, Environmental & Occupational Health
Alexandra Tate, Karen Lutfey Spencer
Summary: Doctors and sociologists have been trying to understand why patients seek medical help but resist treatment recommendations. By analyzing a videotaped interaction of a patient resisting treatment, we show how resistance is manifested through the doctor's actions. This paradox has implications not only for cancer treatment but also for other doctor-patient decisional conflicts.
JOURNAL OF HEALTH AND SOCIAL BEHAVIOR
(2023)
Review
Neurosciences
Maged Zeineldin, Anand G. Patel, Michael A. Dyer
Summary: Neuroblastoma, a deadly cancer in children, may be caused by developmental arrest of neural-crest-derived progenitor cells. Understanding this concept could lead to new clinical management strategies.
Article
Biochemistry & Molecular Biology
Marjorie Durand, Myriam Oger, Krisztina Nikovics, Julien Venant, Anne-Cecile Guillope, Eugenie Jouve, Laure Barbier, Laurent Begot, Florence Poirier, Catherine Rousseau, Olivier Pitois, Laurent Mathieu, Anne-Laure Favier, Didier Lutomski, Jean-Marc Collombet
Summary: The study used an immunogenic material, metakaolin, as an alternative spacer in the Masquelet model and found that the metakaolin-induced membranes had higher osteogenic activity and a significant expansion of the macrophage population, supporting bone regeneration more effectively than PMMA-induced membranes.
Article
International Relations
Sebastian Knecht
Summary: The international state system is characterized by hierarchical relationships, including within intergovernmental organizations (IGO). This article explores how institutionalized inequality is formed within IGOs and investigates the factors that can lead to changes or collapses in these hierarchies. Using the example of the European Organization for Nuclear Research (CERN), the article demonstrates how agency restraint and system rigidity can contribute to the mismanagement of stratification within IGOs.
JOURNAL OF INTERNATIONAL RELATIONS AND DEVELOPMENT
(2023)