Journal
ORTHOPEDIC CLINICS OF NORTH AMERICA
Volume 42, Issue 4, Pages 555-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ocl.2011.07.005
Keywords
Intervertebral disk; Nucleus pulposus; Cell transplantation; Stem cell; Regenerative medicine
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- AO Spine International
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The use of stem cell applications has been explored and aimed at regenerating the intervertebral disk. The microenvironment in which cells of the intervertebral disk reside is harsh; however, researchers have reported on many applications for stem cells, including research aimed at defining and stimulating endogenous stem cell populations, methods to induce stem cell differentiation toward intervertebral disk cell phenotype in vivo, and direct transplantation of stem cells into damaged intervertebral disk to promote transplanted site-dependant differentiation. Successful results have been reported, although limitations remain. This article reviews the current status of stem cell research as applied to the intervertebral disk.
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