Article
Dentistry, Oral Surgery & Medicine
Y. Zeng, E. Baugh, S. Akyalcin, A. Letra
Summary: Mutations in WNT10A gene have been frequently associated with tooth agenesis, with most of the variants related to this condition affecting protein function and leading to decreased WNT signaling.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Genetics & Heredity
Kaoru Yoshinaga, Akihiro Yasue, Silvia Naomi Mitsui, Yoshiyuki Minegishi, Seiichi Oyadomari, Issei Imoto, Eiji Tanaka
Summary: WNT molecules regulate various biological functions, including body axis formation, organ development, and cell proliferation and differentiation. WNT10A and WNT10B, considered as genes of the same origin, have been identified as causative genes for tooth deficiency in humans. However, the disrupted mutant of each gene does not show a decrease in teeth number.
Article
Medicine, General & Internal
Haochen Liu, Bichen Lin, Hangbo Liu, Lanxin Su, Hailan Feng, Yang Liu, Miao Yu, Dong Han
Summary: The goal of this study was to identify pathogenic gene variants in patients with odonto-onycho-dermal dysplasia syndrome (OODD) or nonsyndromic tooth agenesis. Through whole-exome sequencing and genotype-phenotype analysis, multiple variants of the WNT10A gene were identified, showing an association with different degrees of tooth agenesis.
Review
Biochemistry & Molecular Biology
Wanlu Ouyang, Charlene E. Goh, Wei Bo Ng, Fook Tim Chew, Eric Peng Huat Yap, Chin-ying Stephen Hsu
Summary: Atopic dermatitis and tooth developmental abnormalities often occur together in some patients. It is suggested that there may be a common underlying mechanism involving gene mutations and protein interactions. This review explores the key gene mutations and signaling pathways associated with both diseases and identifies a possible association between the Wnt/beta-catenin signaling pathway and desmosomal proteins. Further research is needed to understand the mechanisms driving their co-occurrence and development of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Kang Yu, Jiaqi Dou, Wei Huang, Feng Wang, Yiqun Wu
Summary: This study conducted whole-exome sequencing on 131 tooth agenesis patients and identified pathogenic variants in 73 patients, providing a molecular diagnostic rate for tooth agenesis. The study found that WNT10A and EDA are the most common causative genes associated with tooth agenesis.
Article
Oncology
Fazlur Rahman Talukdar, Sheila C. Soares Lima, Rita Khoueiry, Ruhina Shirin Laskar, Cyrille Cuenin, Bruna Pereira Sorroche, Anne-Claire Boisson, Behnoush Abedi-Ardekani, Christine Carreira, Diana Menya, Charles P. Dzamalala, Mathewos Assefa, Abraham Aseffa, Vera Miranda-Goncalves, Carmen Jeronimo, Rui M. Henrique, Ramin Shakeri, Reza Malekzadeh, Nagla Gasmelseed, Mona Ellaithi, Nitin Gangane, Daniel R. S. Middleton, Florence Le Calvez-Kelm, Akram Ghantous, Maria Leon Roux, Joachim Schuz, Valerie McCormack, M. Iqbal Parker, Luis Felipe Ribeiro Pinto, Zdenko Herceg
Summary: This study investigated tumor-specific DNA methylation in ESCC cases from high-incidence countries, identifying thousands of differentially methylated positions and regions, particularly in gene regions associated with transcription activation. Prioritized genes for replication showed consistent methylation differences and downregulation in tumors. The study highlights the potential of these DNA methylation events as tumor-specific markers for further biomarker discovery.
Review
Biochemistry & Molecular Biology
Zheng Fang, Devi Atukorallaya
Summary: Tooth number anomalies are common congenital dental problems, and the precise number of teeth is crucial for proper function and aesthetics. This article proposes a regulatory network for tooth number based on the dentition formation process and summarizes recent studies on early tooth development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Kuan-Yu Chu, Yin-Lin Wang, Yu-Ren Chou, Jung-Tsu Chen, Yi-Ping Wang, James P. Simmer, Jan C. -C. Hu, Shih-Kai Wang
Summary: Familial tooth agenesis, caused by mutations in genes involved in WNT/beta-catenin signaling, is a common craniofacial anomaly in humans. This study identified pathogenic mutations in the LRP6 gene contributing to FTA and suggested that mutations in LRP6, especially in combination with WNT10A variants, may lead to more severe phenotypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Physiology
Erika Calvano Kuechler, Caio Luiz Bitencourt Reis, Alice Correa Silva-Sousa, Guido Artemio Maranon-Vasquez, Mirian Aiko Nakane Matsumoto, Aline Sebastiani, Rafaela Scariot, Eva Paddenberg, Peter Proff, Christian Kirschneck
Summary: Genetic polymorphisms in BMP2 and SMAD6 were found to be associated with isolated tooth agenesis in this study.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haochen Liu, Hangbo Liu, Lanxin Su, Jinglei Zheng, Hailan Feng, Yang Liu, Miao Yu, Dong Han
Summary: This study investigates and identifies PAX9 gene variants in Chinese families with non-syndromic tooth agenesis. Through sequencing and experiments, it identifies four novel heterozygous variants and studies their effects on function. Additionally, it analyzes the tooth missing positions caused by PAX9 variants and provides valuable information for genetic counseling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Miao Yu, Hangbo Liu, Yang Liu, Jinglei Zheng, Junyi Wu, Kai Sun, Hailan Feng, Haochen Liu, Dong Han
Summary: In this study, a novel KDF1 variant associated with human tooth agenesis was identified. Functional analysis showed that KDF1 variants inhibited the activation of canonical Wnt signaling. Furthermore, phenotypic analyses revealed tooth and gingival epithelial developmental anomalies related to the KDF1 variant. These findings broaden the phenotypic spectrum of KDF1-related disorders and provide new evidence for the crucial role of KDF1 in regulating human dental and oral epithelial development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Chin-Han Chang, Chi-Hua Chang, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: This study investigated the prevalence of tooth agenesis, tooth malformation, and eruption patterns of upper canines/first premolars in Taiwanese children. The results suggest a strong correlation between the patterns of dental anomalies and the cleft sites in cleft lip and cleft palate patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Rong Lan, Yiqun Wu, Qinggang Dai, Feng Wang
Summary: This study reviewed the pathogenic mechanisms and clinical manifestations of syndromes with tooth agenesis, finding that the causes of syndromic TA are highly complex, including gene mutations, abnormal crucial molecules, and chromosomal anomalies.
Article
Medicine, General & Internal
Barbara Biedziak, Ewa Firlej, Justyna Dabrowska, Agnieszka Bogdanowicz, Malgorzata Zadurska, Adrianna Mostowska
Summary: This study identified pathogenic and likely pathogenic variants associated with non-syndromic tooth agenesis (ns-TA) through screening coding sequences of candidate genes. Known candidate genes and newly discovered gene variants may play important roles in the development of ns-TA. Further research is needed to confirm the role of these genes and understand the etiology of ns-TA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Shirley Schonberger, Yehoshua Shapira, Aikaterini Maria Pavlidi, Tamar Finkelstein
Summary: The study evaluated the prevalence and patterns of tooth agenesis among orthodontic individuals, finding an 11% prevalence of missing permanent teeth, with a higher tendency in females and in the maxilla compared to the mandible. Bilateral missing maxillary lateral incisors and mandibular second premolars were more prevalent than unilateral missing teeth.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhen Shen, Caroline Wichnieski, Everdan Carneiro, Gustavo P. Garlet, Ariadne Letra, Renato M. Silva
Summary: This study identified over 100 differentially expressed miRNAs in apical periodontitis, with miR-10a-5p showing the most significant up-regulation. It may play a crucial role in suppressing inflammation and promoting healing in this condition.
JOURNAL OF ENDODONTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhen Shen, Helen Tsao, Sean LaRue, Richard Liu, Timothy C. Kirkpatrick, Leticia Chaves de Souza, Ariadne Letra, Renato M. Silva
Summary: The study found that treatment of SCAPs with VEGF and NGF significantly increased the mRNA expression levels of dentin and transforming growth factor markers, and this treatment with growth factors also led to increased expression of DSPP, DMP1, and TGFB1 mRNA levels in LPS-challenged SCAPs.
JOURNAL OF ENDODONTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Akshita Mann, Yu Zeng, Timothy Kirkpatrick, Ransome van der Hoeven, Renato Silva, Ariadne Letra, Leticia Chaves de Souza
Summary: The study compared the properties of different endodontic sealers, revealing similar physicochemical properties between BCH and BC, but with higher solubility, and higher cytotoxicity for AHP. Temperature affected the setting time and flow of the sealers, indicating that the choice of sealer should be based on the obturation method.
JOURNAL OF ENDODONTICS
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Anita Aminoshariae, Amir Azarpazhooh, Anibal R. Diogenes, Ashraf F. Fouad, Gerald N. Glickman, Jianing He, Anil Kishen, Ariadne M. Letra, Linda Levin, Frank C. Setzer, Franklin R. Tay, Kenneth M. Hargreaves
JOURNAL OF ENDODONTICS
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Anita Aminoshariae, Amir Azarpazhooh, Anibal R. Diogenes, Ashraf F. Fouad, Gerald N. Glickman, Jianing He, Anil Kishen, Ariadne M. Letra, Linda Levin, Frank C. Setzer, Franklin R. Tay, Kenneth M. Hargreaves
JOURNAL OF ENDODONTICS
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Anita Aminoshariae, Amir Azarpazhooh, Anibal R. Diogenes, Ashraf F. Fouad, Gerald N. Glickman, Jianing He, Anil Kishen, Ariadne M. Letra, Linda Levin, Frank C. Setzer, Franklin R. Tay, Kenneth M. Hargreaves
JOURNAL OF ENDODONTICS
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Anita Aminoshariae, Amir Azarpazhooh, Anibal R. Diogenes, Ashraf F. Fouad, Gerald N. Glickman, Jianing He, Anil Kishen, Ariadne M. Letra, Linda Levin, Frank C. Setzer, Franklin R. Tay, Kenneth M. Hargreaves
JOURNAL OF ENDODONTICS
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Anita Aminoshariae, Amir Azarpazhooh, Anibal R. Diogenes, Ashraf F. Fouad, Gerald N. Glickman, Jianing He, Anil Kishen, Ariadne M. Letra, Linda Levin, Frank C. Setzer, Franklin R. Tay, Kenneth M. Hargreaves
JOURNAL OF ENDODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Grace M. De Souza, Tamanna Tiwari, Christopher H. Fox, Patricia A. Miguez, Ariadne Letra, Maria L. Geisinger, Mangala Patel, Luciana Shaddox, Effie Ioannidou
Summary: This study investigated the impact of the COVID-19 pandemic on research productivity, work-life arrangements, and mental health of dental professionals worldwide. The findings revealed that younger individuals and women were disproportionately affected, and institutional support played a crucial role in mitigating the effects of the pandemic.
JOURNAL OF DENTAL EDUCATION
(2023)
Review
Endocrinology & Metabolism
Ariadne Letra
Summary: This review summarizes the recent progress in genetic studies on nonsyndromic tooth agenesis, discussing the challenges and advancements in understanding the underlying genetic factors. It highlights the role of next-generation sequencing technologies in identifying new genes and variants related to the condition.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jordano Francio, Glaucia T. das Neves, Leticia C. Souza, Everdan Carneiro, Renato M. Silva, Ariadne Letra
Summary: This study aims to evaluate the expression of genes involved in chronic pain conditions in apical periodontitis (AP) tissues. The findings show that MMP9, TIMP1, TNFA, CAMK4, and COMT are significantly upregulated in AP tissues, indicating their potential involvement in AP pathogenesis.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Han Na Cho, Leticia Chaves de Souza, Cleverick Johnson, John R. Klein, Timothy C. Kirkpatrick, Renato Silva, Ariadne Letra
Summary: This study compared the differential gene expression in dental pulp tissues between individuals with a history of COVID-19 and those without. The results suggest that COVID-19 may dysregulate the expression of inflammatory genes in inflamed dental pulp.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lauren E. Petty, Renato Silva, Leticia Chaves de Souza, Alexandre R. Vieira, Douglas M. Shaw, Jennifer E. Below, Ariadne Letra
Summary: This study is the first genome-wide association study of apical periodontitis (AP) in a large and well-characterized population. It identified novel genes/loci associated with AP and specific contributions to AP risk in men and women. Additionally, it revealed significant associations with other systemic conditions. These findings provide strong evidence for host-mediated effects on AP susceptibility.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Talita Tartari, Caroline Wichnieski, Renato Menezes Silva, Ariadne Letra, Marco Antonio Hungaro Duarte, Clovis Monteiro Bramante
Summary: Different final irrigation protocols can affect the dentin surface characteristics and the adhesion of endodontic sealers. Among them, the protocols of 2.5% sodium hypochlorite (NaOCl) + 17% ethylenediaminetetraacetic acid (EDTA) and 5% NaOCl + 18% etidronate (HEDP) showed relatively high push-out bond strength after 7 days and 20 months.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Review
Dentistry, Oral Surgery & Medicine
L. Sangalli, L. C. Souza, A. Letra, L. Shaddox, E. Ioannidou
Summary: There has been a growing interest in the scientific community regarding the influence of sex and gender differences on health and disease. This is particularly important in the field of oral diseases, where evidence suggests that sexual dimorphism plays a role in disease predisposition and progression. However, current research lacks consideration of gender and other psychosocial and external factors that may impact oral health.
JOURNAL OF DENTAL RESEARCH
(2023)
