Article
Gastroenterology & Hepatology
Carlos Gonzalez-Alayon, Esteban Porrini, Sergio Luis-Lima, Natalia Negrin-Mena, Miguel Moreno, Dalia Morales-Arraez, Federico Gonzalez-Rinne, Laura Diaz-Martin, Flavio Gaspari, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Alberto Ortiz-Arduan, Manuel Hernandez-Guerra
Summary: In patients with cirrhosis, formulas for estimating renal function, whether specific to this population or classic equations, have not been proven to be reliable. The study found poor agreement between estimated and measured glomerular filtration rate in cirrhotic patients, indicating caution should be exercised when using eGFR in this population.
LIVER INTERNATIONAL
(2022)
Letter
Medicine, General & Internal
Jonathan R. Genzen, Rhona J. Souers, Lauren N. Pearson, David M. Manthei, Allison B. Chambliss, Zahra Shajani-Yi, W. Greg Miller
Summary: This study examines the awareness and adoption of new equations for estimated glomerular filtration rate (eGFR) in clinical laboratories that participated in the first general chemistry proficiency testing survey in 2022. The new equations, proposed by the Chronic Kidney Disease Epidemiology Collaboration, eliminate race-adjustment factors and include equations based on creatinine alone or a combination of creatinine and cystatin C.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Markus Cybulla, Kathleen Nicholls, Sandro Feriozzi, Ales Linhart, Joan Torras, Bojan Vujkovac, Jaco Botha, Christina Anagnostopoulou, Michael L. West
Summary: This study evaluated the impact of agalsidase alfa on renal decline in patients with Fabry disease, finding that patients with high baseline proteinuria had a faster decline in eGFR, while the decline in eGFR in classic Fabry disease patients was not associated with baseline proteinuria. This suggests that early treatment and good proteinuria control may play a significant role in renal protection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Veronica T. Costa e Silva, Luiz A. Gil Jr, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro Jr, Maria Dp Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonangelo, Lia Marcal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann
Summary: This study compares the performance of different equations for glomerular filtration rate (GFR) evaluation in cancer patients. The results show that the Cockcroft-Gault equation is the least accurate, while the CKD-EPI equation and eGFRcr-cys equation perform better. Therefore, it is recommended to adopt guideline-recommended methods for GFR evaluation in oncology practice and clinical trials.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Chi D. Chu, Fang Xia, Yuxian Du, Rakesh Singh, Delphine S. Tuot, Julio A. Lamprea-Montealegre, Ralph Gualtieri, Nick Liao, Sheldon X. Kong, Todd Williamson, Michael G. Shlipak, Michelle M. Estrella
Summary: This study found that approximately two-thirds of patients with hypertension or diabetes were undetected for albuminuria, leading to an increased risk of chronic kidney disease (CKD) progression and cardiovascular morbidity. Therefore, improving the accuracy and utilization of albuminuria testing can help reduce the risk of CKD progression and cardiovascular complications.
Article
Cardiac & Cardiovascular Systems
Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh
Summary: This study aimed to investigate the association between eGFR slope and CVD among individuals with and without diabetes. The results showed that a steeper decline in eGFR slope was significantly associated with a higher risk of CVD events in individuals with diabetes, but not in individuals without diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Urology & Nephrology
Gregory L. Hundemer, Christine A. White, Patrick A. Norman, Greg A. Knoll, Navdeep Tangri, Manish M. Sood, Swapnil Hiremath, Kevin D. Burns, Christopher McCudden, Ayub Akbari
Summary: This study validated the 2021 race-free CKD-EPI eGFR equations among kidney transplant recipients, finding that they performed similarly to previous equations that included race correction terms. There was no significant difference in performance between the 2021 CKD-EPI eGFRcr and eGFRcr-cys equations in the kidney transplant population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Dermatology
Jinghang Zhang, Dong Chen, Xuemei Li, Min Ding, Jun Xu, Meijun Wang, Bai Chang
Summary: This study aimed to investigate the association between estimated glomerular filtration rate (eGFR) and prognosis in patients with diabetic foot osteomyelitis (DFO). The results showed that patients with severely reduced eGFR had a higher risk of healing failure, total amputation, and minor amputation compared to patients with normal eGFR. Severely reduced eGFR was identified as an independent predictor for amputation and healing failure in DFO patients.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Barbara K. Burton, Francois Feillet, Katryn N. Furuya, Sachin Marulkar, Manisha Balwani
Summary: This study reports the final results of using sebelipase alfa enzyme replacement therapy in patients with LAL-D for up to 5 years. It shows that this treatment can sustain improvements in liver function and lipid abnormalities without progression of liver disease.
JOURNAL OF HEPATOLOGY
(2022)
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Maurice Laville
Summary: Nephroprotective treatments may lead to a drop in glomerular filtration rate, which could be related to the intensity of baseline glomerular anomalies and potential treatment benefits. The study by Oshima et al. further confirms this relationship in diabetic patients with chronic kidney disease under sodium-glucose cotransporter 2 inhibition.
KIDNEY INTERNATIONAL
(2021)
Article
Clinical Neurology
Wei Liu, Xue-Lian Ma, Hong-Qiu Gu, Hao Li, Zi-Xiao Li, Yong-Jun Wang
Summary: This study investigated the association between hyperhomocysteinemia and in-hospital mortality following ischemic stroke, transient ischemic attack, or intracerebral hemorrhage. The results showed that hyperhomocysteinemia was associated with in-hospital mortality, but this association disappeared after controlling for renal function.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Medicine, General & Internal
Timothy L. Pruett, Gabriel R. Vece, Robert J. Carrico, David K. Klassen
Summary: Despite a shortage of kidney supply in the US, kidneys from older deceased donors are underutilized due to concerns about graft quality and transplant durability. However, the study found that one-year graft survival does not significantly differ based on donor age, with the primary factor affecting longevity being the level of kidney function gained post-transplantation. Effective decision-making tools are needed to ensure transplanting older kidneys provides sufficient renal function to justify the procedure.
Article
Urology & Nephrology
Rosa Miquel Rodriguez, Sergio Luis-Lima, Juan Manuel Fernandez, Maria Vanesa Perez Gomez, Beatriz Gonzalez Toledo, Marian Cobo, Patricia Delgado-Mallen, Beatriz Escamilla, Cristina Oramas Marco, Sara Estupinan, Coriolano Cruz Perera, Natalia Negrin Mena, Laura Diaz Martin, Sergio Pitti Reyes, Ibrahim Hernandez Gonzalez, Federico Gonzalez-Rinne, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Begona Lopez-Botet Zulueta, Armando Torres, Jose Carlos Rodriguez Perez, Flavio Gaspari, Alberto Ortiz, Esteban Porrini
Summary: The study evaluated the agreement between measured GFR and estimated GFR by different formulas in ADPKD patients. Results showed that none of the formulas had acceptable agreement with measured GFR, indicating significant deviation from real renal function.
JOURNAL OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Sam O. Kleeman, Mattia Cordioli, Paul R. H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, Tobias Janowitz
Summary: This study found a significant association between cystatin C production and the severity and mortality of COVID-19 in patients, suggesting its potential use in stratifying patients and its functional role in the host response to COVID-19.