Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum

Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor

(2013) Agustin H. Mohedas et al.   ACS Chemical Biology

Functional Interaction of Osteogenic Transcription Factors Runx2 and Vdr in Transcriptional Regulation of Opn during Soft Tissue Calcification

(2013) Ann-Kathrin Sowa et al.   AMERICAN JOURNAL OF PATHOLOGY

Insulin suppresses distal-less homeobox 5 expression through the up-regulation of microRNA-124 in 3T3-L1 cells

(2013) Abdul S. Qadir et al.   EXPERIMENTAL CELL RESEARCH

Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in theENPP1gene

(2012) Q. Li et al.   BRITISH JOURNAL OF DERMATOLOGY

ABCC6 Localizes to the Mitochondria-Associated Membrane

(2012) Lisa J. Martin et al.   CIRCULATION RESEARCH

Activating transcription factor 4 regulates stearate-induced vascular calcification

(2012) Masashi Masuda et al.   JOURNAL OF LIPID RESEARCH

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

Generalized Arterial Calcification of Infancy and Pseudoxanthoma Elasticum Can Be Caused by Mutations in Either ENPP1 or ABCC6

(2011) Yvonne Nitschke et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Abcc6 Deficiency Causes Increased Infarct Size and Apoptosis in a Mouse Cardiac Ischemia-Reperfusion Model

(2011) Imran N. Mungrue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification

(2011) Marcel Liberman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ALK1 as an emerging target for antiangiogenic therapy of cancer

(2011) S. I. Cunha et al.   BLOOD

The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter

(2011) Corinne Niger et al.   BONE

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

Fetuin-A Regulation of Calcified Matrix Metabolism

(2011) Willi Jahnen-Dechent et al.   CIRCULATION RESEARCH

Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate

(2011) Catherine M. Shanahan et al.   CIRCULATION RESEARCH

Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis

(2011) F. Barron et al.   DEVELOPMENT

Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway

(2011) Xiao Yu Tian et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum

(2011) Georges Lefthériotis et al.   JOURNAL OF VASCULAR SURGERY

Phosphate, oxidative stress, and nuclear factor-κB activation in vascular calcification

(2011) Ziyad Al-Aly   KIDNEY INTERNATIONAL

Wnt Signaling and Dupuytren's Disease

(2011) Guido H. Dolmans et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis

(2010) Emmanouil Kyriakakis et al.   CELLULAR SIGNALLING

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2

(2010) Atsushi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-α's effects on proliferation and apoptosis in human mesenchymal stem cells depend on RUNX2 expression

(2010) Olfa Ghali et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome

(2010) Olivier M Vanakker et al.   LABORATORY INVESTIGATION

Novel Links among Wnt and TGF-β Signaling and Runx2

(2010) Thomas L. McCarthy et al.   MOLECULAR ENDOCRINOLOGY

Endoplasmic reticulum stress-mediated apoptosis is activated in vascular calcification

(2009) Xiaohui Duan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries

(2009) Mei Y. Speer et al.   CIRCULATION RESEARCH

Vascular endothelial growth factor gene polymorphisms as prognostic markers for ocular manifestations in pseudoxanthoma elasticum

(2009) R. Zarbock et al.   HUMAN MOLECULAR GENETICS

Elevated circulating levels of matrix metalloproteinases MMP-2 and MMP-9 in pseudoxanthoma elasticum patients

(2009) Ulf Diekmann et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Fibroblast protein profile analysis highlights the role of oxidative stress and vitamin K recycling in the pathogenesis of pseudoxanthoma elasticum

(2009) Federica Boraldi et al.   Proteomics Clinical Applications

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

Vascular calcification and bone disease: the calcification paradox

(2009) Veerle Persy et al.   TRENDS IN MOLECULAR MEDICINE

Vascular Calcification

(2008) Linda L. Demer et al.   CIRCULATION

Evidence for a calcification process in the trabecular meshwork

(2008) Teresa Borrás et al.   EXPERIMENTAL EYE RESEARCH

Structural Coupling of Smad and Runx2 for Execution of the BMP2 Osteogenic Signal

(2008) Amjad Javed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

(2008) Chang Hyun Byon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming growth factor-β/connective tissue growth factor axis in the kidney

(2007) Weier Qi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY