Article
Clinical Neurology
Eleni Bakola, Aristeidis H. Katsanos, Lina Palaiodimou, Aikaterini Theodorou, Maria-Ioanna Stefanou, Maria Chondrogianni, Elisabeth Andreadou, Marianna Papadopoulou, Vasileios Konstantakos, Konstantinos Voumvourakis, Stefanos Lachanis, Georgios Tsivgoulis
Summary: The use of coiling for intracranial aneurysms has become more popular in recent years, leading to rare complications such as white matter enhancing lesions. This case highlights the importance of monitoring for delayed and recurring inflammatory changes after endovascular aneurysmal treatment with coiling devices.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Immunology
Chiara Agrati, Barbara Bartolini, Veronica Bordoni, Franco Locatelli, Maria Rosaria Capobianchi, Antonino Di Caro, Concetta Castilletti, Giuseppe Ippolito
Summary: The immune response to emerging viral pathogens and its impact on immunocompromised hosts is a critical topic that requires exploration. Understanding the immune response profile, clinical presentation, viral shedding, and the role of vaccination is essential in addressing the challenges posed by these infections.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Dermatology
Jianing Wang, Zhimin Duan, Xu Chen, Min Li
Summary: Dermal fibroblasts play important roles in wound healing, extracellular matrix production, hair cycling, and defense against infection. They can sense pathogen components and produce pro-inflammatory cytokines, chemokines, and antimicrobial peptides. In addition, they secrete growth factors and matrix metalloproteinases to aid tissue repair. The interaction between dermal fibroblasts and immune cells may enhance the immune response against infection.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Clinical Neurology
Qihua Chen, Jianguang Tang, Hainan Zhang, Lixia Qin
Summary: This report presents a case of late-onset cblC deficiency with brown desquamating dermatitis and bilateral cerebellar abnormalities. The diagnosis was confirmed by identifying a homozygous variant in the MMACHC gene using whole-exome sequencing. Despite treatment, the patient did not experience clinical improvement, possibly due to a delayed diagnosis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Engineering, Chemical
McDominic Chimaobi Eze, Lida Ebrahimi Vafaei, Charles Tochukwu Eze, Turgut Tursoy, Dilber Uzun Ozsahin, Mubarak Taiwo Mustapha
Summary: In this study, a novel MSHA model was developed and demonstrated for skin lesion detection. The model utilizes unique architectural designs and an effective training strategy to accurately capture and extract relevant features of chickenpox and shingles lesions. It outperformed state-of-the-art models in terms of accuracy and demonstrated superior performance in detecting these lesions.
Article
Surgery
Haley P. Hostetler, Megan L. Neely, Elizabeth Lydon, Lara A. Danziger-Isakov, Jamie L. Todd, Scott M. Palmer
Summary: The study found that a considerable number of lung transplant candidates had undetectable virus-specific antibody titers, especially for varicella zoster virus and measles. Younger age groups had lower immunity rates. These results highlight the importance of screening for immunity to vaccine-preventable infections in this population and the need for revaccination in selected patients before transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Dermatology
Didem Dincer Rota, Mehmet Can Emeksiz
Summary: Granulomatous skin disorders are a diverse group of diseases characterized by granuloma formation on histopathology, triggered by various stimuli including infectious and non-infectious factors. Infectious granuloma formation may result from the immune system's inability to eliminate an agent, and can be related to the pathogenicity of the infectious agent or the patient's immunity. Common infectious agents causing granulomatous reactions include mycobacteria, fungal infections, or parasites. This review focuses on summarizing granulomatous skin diseases with infectious causes frequently encountered in clinical practice.
TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiao-Xin Chang, Jia-Ling Lyu, Po-Yuan Wu, Kuo-Ching Wen, Chang-Cheng Chang, Hsiu-Mei Chiang
Summary: In this study, the antioxidation and anti-inflammation effects of Coffea arabica extract (CAE) and its regulation of the skin barrier and immune functions in AD were investigated. The results showed that CAE decreased reactive oxygen species levels and inhibited the translocation of nuclear factor-kappa B, leading to reduced secretion of interleukin-1 beta and IL-6. CAE also restored levels of skin barrier-related markers and reduced inflammation and transepidermal water loss in AD mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Humaira Sadaf, Bihong Zhao, Laura C. Lelenwa, Manish K. Patel, Soma S. Jyothula, Igor D. Gregoric, L. Maximilian Buja
Summary: In patients with chronic lung diseases undergoing lung transplantation, granulomatous infections can lead to post-transplant complications, including invasive infections and acute cellular rejection, predisposing to chronic graft dysfunction. Both pre-and post-transplant antifungal prophylaxis reduces fungal load and complication risk post-transplant.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Yangyang Hu, Lin Feng, Weidan Jiang, Pei Wu, Yang Liu, Shengyao Kuang, Ling Tang, Xiaoqiu Zhou
Summary: This study revealed that lysine deficiency in grass carp suppressed growth performance, decreased ability to resist skin lesion morbidity, impaired immune organ's immune response, and aggravated inflammatory response by affecting gene expressions of various cytokines and signal transduction pathways. Dietary lysine requirements for grown-up grass carp were estimated through regression analysis.
Article
Immunology
Elise Van Breedam, Tamariche Buyle-Huybrecht, Jonas Govaerts, Pieter Meysman, Andrea Bours, Marlies Boeren, Julia Di Stefano, Thalissa Caers, Hans De Reu, Laura Dirkx, Jolien Schippers, Esther Bartholomeus, Marielle Lebrun, Catherine Sadzot-Delvaux, Paulina Rybakowska, Marta E. Alarcon-Riquelme, Concepcion Maranon, Kris Laukens, Peter Delputte, Benson Ogunjimi, Peter Ponsaerts
Summary: Using hiPSC-derived neural cell models, the study investigated the interactions between VZV and neural cells. It was found that macrophages were unable to mount an antiviral immune response in VZV-infected hiPSC-neurons. Further analysis suggested the involvement of other cell types in orchestrating an efficient antiviral immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Ramesh Bhosale, Mallika Alexander, Prasad Deshpande, Vandana Kulkarni, Nikhil Gupte, Amita Gupta, Jyoti Mathad
Summary: Accurate tuberculosis infection tests are crucial for pregnant women, especially those with HIV, due to their high risk of TB disease. Pregnancy can impact TB infection test results and reduce the IFN-gamma response to M. tuberculosis stimulation. Despite adequate CD4 counts, women with HIV express lower levels of IFN-gamma compared to women without HIV, potentially contributing to the higher TB incidence in postpartum women with HIV.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Katsuyuki Katahira, Shinya Watanabe, Kentaro Wakamatsu, Zenzo Nagasawa, Masayuki Kawasaki, Longzhu Cui
Summary: In this study, the complete genome sequence of Mycobacterium heckeshornense strain JMUB5695, isolated from necrotizing granulomatous lesions in a lung cancer patient, was reported. The genome consists of a 4,865,109-bp chromosome with a GC content of 65.9% and does not contain any plasmids.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Multidisciplinary Sciences
Lucienne Tritten, Nina Gillis-Germitsch, Tobias Kockmann, Manuela Schnyder
Summary: Blood proteins in dogs infected with the cardiopulmonary nematode A. vasorum show significant changes, with 139 proteins being up- or downregulated post-infection. Upregulated proteins include chitinase 3-like 1 and pulmonary surfactant-associated protein B, while downregulated proteins involve the complement and coagulation cascades. These findings provide new insights into the pathomechanisms of bleeding disorders in A. vasorum-infected dogs.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Jin-Su Oh, Sang-Jun Lee, Se-Young Choung
Summary: The study found that Lithospermum erythrorhizon can alleviate clinical symptoms of atopic dermatitis in mice by modulating immune balance and restoring skin barrier function.
Article
Biochemistry & Molecular Biology
Kourosh Ahmadzadeh, Marie Pereira, Margot Vanoppen, Eline Bernaerts, Jeong-Hun Ko, Tania Mitera, Christy Maksoudian, Bella B. Manshian, Stefaan Soenen, Carlos D. Rose, Patrick Matthys, Carine Wouters, Jacques Behmoaras
Summary: Macrophages can undergo cell fusion and multinucleation to form multinucleated giant cells. Comparative transcriptomics and functional assays reveal that multinucleation causes downregulation of macrophage identity and specialization in functionality, such as enhanced phagocytosis and mitochondrial function.
Article
Pediatrics
Lien De Somer, Brigitte Bader-Meunier, Sylvain Breton, Sara Brachi, Carine Wouters, Francesco Zulian
Summary: This study retrospectively collected data on the clinical features, radiological manifestations, and disease course of dry synovitis (DS) patients and compared them with rheumatoid factor negative polyarticular juvenile idiopathic arthritis (RFneg-polyJIA) patients. The results showed that DS patients had a higher number of joint involvement, more severe joint contractures, and a longer diagnostic delay compared to RFneg-polyJIA patients.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Immunology
Karen Yu, Luna Dillemans, Mieke Gouwy, Helena Bessa, Mieke Metzemaekers, Erik Martens, Patrick Matthys, Xavier Bossuyt, Patrick Verschueren, Carine Wouters, Lien De Somer, Paul Proost
Summary: In this study, a fluorescent in vitro assay was improved to characterize endogenous PAD activity in complex samples. The results showed similar levels of PAD activity in synovial fluids of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients, while citrullination was limited in joints of patients with gout or Lyme's disease. Interestingly, a higher level of extracellular citrullination was only found in blood of anti-CCP-positive RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luna Dillemans, Lien De Somer, Barbara Neerinckx, Paul Proost
Summary: Chemokines play a crucial role in initiating and perpetuating synovitis by promoting leukocytes migration into inflamed joints. The interaction between CXCR3 and CXCL9, CXCL10, and CXCL11 regulates the trafficking of various immune cells towards inflammatory niches. These chemokines are involved in autoinflammatory and autoimmune diseases, and their presence in bodily fluids of patients with inflammatory arthritis highlights their potential as therapeutic targets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Anne Rochtus, Lieven Lagae, Katrien Jansen, Lien De Somer, Francois Vermeulen, Francis de Zegher
Summary: In this case report, a patient with tuberculous meningoencephalitis developed significant weight gain after antituberculosis treatment, which improved after 18 months of therapy. This suggests that antituberculosis treatment can alleviate weight gain due to pituitary dysfunction. Further studies are needed to investigate the incidence of pituitary dysfunction in the pediatric population.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Review
Chemistry, Medicinal
Mieke Metzemaekers, Bert Malengier-Devlies, Mieke Gouwy, Lien De Somer, Fernando de Queiroz Cunha, Ghislain Opdenakker, Paul Proost
Summary: Neutrophils are powerful effector cells that play crucial roles in fighting pathogens and modulating immune responses. Recent evidence suggests that these cells are more versatile and heterogeneous than previously thought, and are involved in various diseases including cancer and autoimmune disorders. This review discusses the kinetics of neutrophils and their activation products, as well as their multifaceted functions in health and disease, focusing on studies using primary human cells.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Rheumatology
Hermine Brunner, Nikolay Tzaribachev, Ingrid Louw, Inmaculada Calvo Penades, Francisco Avila-Zapata, Gerd Horneff, Ivan J. Foeldvari, Daniel Kingsbury, Maria Eliana Paz Gastanaga, Carine Wouters, Johannes Breedt, Robert Wong, Margarita Askelson, Joe Zhuo, Alberto J. Martini, Daniel Lovell, Nicolino Ruperto
Summary: This study aimed to investigate the frequency and trajectories of individual patients with polyarticular-course juvenile idiopathic arthritis (JIA) achieving various composite end points on abatacept treatment. The results showed that patients achieved composite end points of low disease activity (LDA) with minimal pain, LDA with Childhood Health Assessment Questionnaire disability index score of 0, and 50% improvement in American College of Rheumatology criteria for JIA (ACR50) with minimal pain at 4 months. The proportion of patients meeting these end points increased over 21 months of abatacept treatment.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Wafa Hamdi, Hanene Ferjani, Raffaella Carlomagno, Perrine Dusser, Stephane Echaubard, Alexandre Belot, Kenza Bouayed, Carine Wouters, Olivier Richer, Veronique Hentgen, Anne Lohse, Diana Dan, Daniela Kaiser, Catherine Barbier, Elvira Cannizzaro, Sylvaine Poignant, Isabelle Melki, Michael Hofer
Summary: This study aims to identify the factors associated with poor prognosis of hip involvement in children with juvenile idiopathic arthritis (JIA) and evaluate treatment response. Male gender, enthesitis-related arthritis, and North African origin were found to be factors associated with hip arthritis. Hip inflammation was associated with disease activity parameters, while structural hip progression was associated with early onset of the disease, longer time to diagnosis, geographic origin, and JIA subtypes. Anti-TNF therapy was found to be effective in reducing structural damage progression.
MUSCULOSKELETAL CARE
(2023)
Article
Immunology
Mariia Dzhus, Lisa Ehlers, Marjon Wouters, Katrien Jansen, Rik Schrijvers, Lien De Somer, Steven Vanderschueren, Marco Baggio, Leen Moens, Benjamin Verhaaren, Rik Lories, Giorgia Bucciol, Isabelle Meyts
Summary: Deficiency of human adenosine deaminase type 2 (DADA2) is a rare autoimmune disorder characterized by vasculopathy, immune dysregulation, and hematologic abnormalities. Neurological manifestations, particularly strokes, are a significant feature of DADA2, with brain stem and deep gray matter being commonly affected. Other neurological involvements include neuropathies, focal deficits, ophthalmological findings, convulsions, and headaches. Recognizing the diverse neurological manifestations of DADA2 is crucial for accurate diagnosis and appropriate management.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Pediatrics
M. Wallimann, K. Bouayed, E. Cannizzaro, D. Kaiser, A. Belot, E. Merlin, S. Poignant, C. Wouters, F. Hofer, T. Saurenmann, A. Koryllou, R. Carlomagno, M. Mejbri, M. Hofer, K. Theodoropoulou
Summary: This study aims to identify predictors of disease evolution in patients with systemic juvenile idiopathic arthritis (sJIA). The results suggest that early disease onset, persistence of arthritis in the first year, and the use of synthetic DMARD may predict a persistent disease course.
PEDIATRIC RHEUMATOLOGY
(2023)
Meeting Abstract
Pediatrics
Noel Knops, Nathalie Vanden Eynde, Lien De Somer, Priyanka Koshy
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Nathalie Vanden Eynde, Priyanka Koshy, Lien De Somer, Noel Knops
JOURNAL OF NEPHROLOGY
(2023)
Article
Immunology
Luna Dillemans, Youri Bekhuis, Albrecht Betrains, Karen Yu, Maarten van Hemelen, Noemie Portner, Lien De Somer, Patrick Matthys, Jeroen Breckpot, Thomas Tousseyn, Marijke Peetermans, Paul Proost, Carine Wouters, Steven Vanderschueren
Summary: We report a fatal case of a 20-year-old woman with refractory adult-onset Still's disease accompanied by fulminant macrophage activation syndrome and atypical hemolytic uremic syndrome. This case highlights the importance of prompt genetic assessment of complement-encoding alleles, in addition to HLH-related genes, in patients with severe adult-onset Still's disease with recurrent macrophage activation syndrome and features of thrombotic microangiopathy.
CLINICAL IMMUNOLOGY
(2023)
