Article
Multidisciplinary Sciences
William D. Pineros, Tsvi Tlusty
Summary: This study demonstrates that chiral symmetry can be spontaneously broken in complex, random chemical systems by exploiting environmental energy sources, which may be a mechanism for the emergence of homochirality in life. The research findings suggest that chiral symmetry breaking may occur spontaneously and generically by harnessing energy sources from external environmental drives.
NATURE COMMUNICATIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Miaomiao Zhou, Guiqin Liu, Wenqiang Liu, Mingxia Zhu, Changfa Wang
Summary: This study characterized the molecular cloning, tissue distribution, and functional properties of donkey PepT2, showing higher expression in the kidney and lung compared to other organs. Functional analysis in Chinese hamster ovary cells revealed specific uptake characteristics of PepT2, providing new insights into its crucial role in oligopeptide transport in donkeys.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Chemistry, Multidisciplinary
Johannes Seibel, Zeno Tessari, David B. Amabilino, Steven De Feyter
Summary: Chiral symmetry breaking in molecular adsorption at the solid/liquid interface is achieved by lateral geometric nanoconfinement, which is created at the interface of achiral covalently modified highly-oriented pyrolytic graphite and a racemate by in situ scanning probe lithography. Enantioselective adsorption of chiral molecules is achieved by adjusting the relative orientation between the nanoconfining walls and substrate symmetry direction.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Wenwen Xiong, Qiuyu Zhang, Junjuan Wang, Mengzhen Hao, Binghui Zeng, Huilian Che
Summary: This study assessed the allergenicity of five types of oligopeptides derived from allergenic foods. Various methods including bioinformatics tools, SDS-PAGE, ELISA, cell and animal experiments were used for evaluation. The results showed that although the oligopeptides were derived from allergens, they had low allergenicity.
Article
Plant Sciences
Jing Liu, Yiling Yang, Lauritz Harken, Shu-Ming Li
Summary: Heterologous expression of a three-gene cluster from Streptomyces aurantiacus led to the elucidation of the biosynthetic steps of streptoazine C. The prenyltransferase SasB showed high flexibility towards tryptophan-containing cyclodipeptides. This study provides potential use of enzymes with high substrate promiscuity for generating prenylated derivatives.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Polymer Science
Maozhu Tang, Si-jie Bai, Ran Xu, Rong Zhang, Shi-Qi Li, Yun-Xiang Xu
Summary: Through manipulating the spacer length and oligopeptide binding, a strong and stable polyisoprene elastomer comparable to vulcanized counterpart has been achieved. The mechanical strength and thermal stability of the elastomers increased significantly with the increase of spacer length from 3 to 5 and 7, while maintaining high extensibility. High apparent activation energies and reduced relaxation rate could explain the observed phenomenon, indicating the potential of architecture control in coordinating with supramolecular interactions to broaden polymer applications.
Article
Chemistry, Organic
Alexander Seitz, Raffael C. Wende, Emily Roesner, Dominik Niedek, Christopher Topp, Avene C. Colgan, Eoghan M. McGarrigle, Peter R. Schreiner
Summary: This study presents oligopeptide-catalyzed site-selective acylation of partially protected monosaccharides, achieving high yields and selectivities under mild reaction conditions, suitable for one-pot reactions with multiple consecutive protection steps.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Jean Gillet, Laurence Rongy, Yannick De Decker
Summary: This study investigates a chemical network model that produces chiral enantiomers through autocatalytic reactions from achiral reactants. The results show that the concentration of achiral substrate plays an uncertain role in achieving global homochirality. In 1D systems, a fixed concentration gradient can lead to homogeneous homochirality. In 2D systems, achieving global homochirality is a matter of time, and the optimal amount of achiral material maximizes the enantiomer production rates.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Natsuki Watanabe, Mitsuo Shoji, Koichi Miyagawa, Yuta Hori, Mauro Boero, Masayuki Umemura, Yasuteru Shigeta
Summary: Enantiomeric excesses (ee) of l-amino acids in meteorites are found to be higher than 10%, especially for isovaline (Iva), indicating the presence of a triggering mechanism that amplifies the ee from an initially small value. In this study, the dimeric molecular interactions of alanine (Ala) and Iva in solution were investigated at a precise first-principles level, revealing the chirality-dependent nature of Iva's dimeric interaction and providing molecular-level insights into the enantioselectivity of amino acids in solution.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Satoshi Uchida, Yuto Yamaberi, Masakazu Tanaka, Makoto Oba
Summary: Prolonging protein expression from mRNA is a challenge in mRNA nanomedicine development. mRNA complexed with helix foldamer oligopeptides containing arginine and alpha-aminoisobutyric acids showed higher intracellular stability and maintained efficient protein translation for three days.
Article
Chemistry, Multidisciplinary
Yixin Chen, Guangcheng Wu, Binbin Chen, Hang Qu, Tianyu Jiao, Yintao Li, Chenqi Ge, Chi Zhang, Lixin Liang, Xiuqiong Zeng, Xiaoyu Cao, Qi Wang, Hao Li
Summary: Self-assembly of anionic tetrahedron cage in water via metal-ligand coordination shows stability and chiral selectivity, accommodating various guest molecules in aqueous media.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Biomaterials
Mingxing Ren, Yuzhou Li, He Zhang, Lingjie Li, Ping He, Ping Ji, Sheng Yang
Summary: A new dual-targeting nanocarrier, CH6-PAMAM-C11, was synthesized by covalently modifying G4.0 PAMAM dendrimer with C11 peptide and CH6 aptamer, showing successful accumulation in bone cells, mineralized areas, and tissues. Both in vitro and in vivo experiments confirmed the efficient bone targeting ability of CH6-PAMAM-C11, suggesting potential for drug delivery to bone tissues for osteoporosis treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Eli Bonneure, Amber De Baets, Sam De Decker, Koen van den Berge, Lieven Clement, Wim Vyverman, Sven Mangelinckx
Summary: Diatoms, as a major group of algae, play a significant role in primary production on Earth. A study on the pennate diatom Seminavis robusta revealed the use of multiple sexual cues, including cyclo(l-Pro-l-Pro) pheromone. By synthesizing and evaluating novel pheromone analogs, it was shown that structural modifications can be used to study the pheromone-detection system of S. robusta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Yanquan Fei, Siying Li, Zaoyi Wang, Yong Ma, Jun Fang, Gang Liu
Summary: Our study found that the dietary oligopeptide Ile-Arg-Trp (IRW) can significantly alleviate colon barrier damage and promote intestinal health. Furthermore, we observed that different concentrations of IRW can modulate the abundance of Bacillota, Odoribacter, and Lactobacillus, which are important members of the gut microbiota.
Article
Chemistry, Multidisciplinary
Zhuo-Zheng Xu, Zheng Zhuang, Runlin Cai, Guo-Qiang Lin, Zhigang She, Qunfei Zhao, Qing-Li He
Summary: The biosynthetic mechanism of the 3,6-diene-2,5-diketopiperazine core in fungi was elucidated through heterologous expression and biochemical investigation, shedding light on the formation of this important substructure in marine fungi.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Amra Aksamija, Ange Polidori, Raphael Plasson, Olivier Dangles, Valerie Tomao
Article
Chemistry, Multidisciplinary
Silvia Serra, Ahmed Alouane, Thomas Le Saux, Steve Huvelle, Raphael Plasson, Frederic Schmidt, Ludovic Jullien, Raphael Labruere
CHEMICAL COMMUNICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Gregoire Danger, Arthur Michaut, Manon Bucchi, Laurent Boiteau, Justine Canal, Raphael Plasson, Robert Pascal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2013)
Article
Computer Science, Artificial Intelligence
Raphael Plasson, Axel Brandenburg, Ludovic Jullien, Hugues Bersini
Article
Astronomy & Astrophysics
Gregoire Danger, Raphael Plasson, Robert Pascal
Article
Chemistry, Multidisciplinary
Thomas Le Saux, Raphael Plasson, Ludovic Jullien
CHEMICAL COMMUNICATIONS
(2014)
Review
Chemistry, Multidisciplinary
Gregoire Danger, Raphael Plasson, Robert Pascal
CHEMICAL SOCIETY REVIEWS
(2012)
Article
Chemistry, Multidisciplinary
Matthieu Emond, Thomas Le Saux, Sylvie Maurin, Jean-Bernard Baudin, Raphael Plasson, Ludovic Jullien
CHEMISTRY-A EUROPEAN JOURNAL
(2010)
Article
Chemistry, Multidisciplinary
Matthieu Emond, Thomas Le Saux, Jean-Francois Allemand, Philippe Pelupessy, Raphael Plasson, Ludovic Jullien
CHEMISTRY-A EUROPEAN JOURNAL
(2012)
Article
Chemistry, Physical
Raphael Plasson, Axel Brandenburg, Ludovic Jullien, Hugues Bersini
JOURNAL OF PHYSICAL CHEMISTRY A
(2011)
Article
Biochemistry & Molecular Biology
Kevin Montagne, Raphael Plasson, Yasuyuki Sakai, Teruo Fujii, Yannick Rondelez
MOLECULAR SYSTEMS BIOLOGY
(2011)
Correction
Biochemistry & Molecular Biology
Kevin Montagne, Raphael Plasson, Yasuyuki Sakai, Teruo Fujii, Yannick Rondelez
MOLECULAR SYSTEMS BIOLOGY
(2011)
Article
Biology
Raphael Plasson, Axel Brandenburg
ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES
(2010)
Article
Chemistry, Multidisciplinary
Khaoula Jaouadi, Mehdi Abdellaoui, Etienne Levernier, Pierre-Adrien Payard, Etienne Derat, Thomas Le Saux, Cyril Ollivier, Stephane Torelli, Ludovic Jullien, Raphael Plasson, Louis Fensterbank, Laurence Grimaud
Summary: The metallaphotoredox catalyzed cross-coupling of an aryl bromide with an alkyl bis(catecholato)silicate has been analyzed in depth, revealing two possible reaction mechanisms.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)