Article
Chemistry, Multidisciplinary
Natalia Sanz del Olmo, Juan Carlos Garcia, Rafael Gomez, F. Javier de la Mata, Paula Ortega
Summary: Reactive oxygen species (ROS) play a critical role in human pathophysiological processes, and redox-active groups such as polyphenols are involved in maintaining intracellular redox homeostasis. In this study, a new family of first-generation carbosilane dendrons functionalised with polyphenols at the focal point and dimethylammonium groups at the periphery was successfully synthesized using two strategies. Their antioxidant activity was evaluated using spectrophotometric methods, and a correlation between the number of hydroxyl groups and antioxidant activity was established.
Article
Materials Science, Biomaterials
Wei Guo, Yongjie Wang, Pengqi Wan, Hao Wang, Li Chen, Shaokun Zhang, Chunsheng Xiao, Xuesi Chen
Summary: Bacterial infections and antibiotic resistance have become a global healthcare crisis. Cationic amphiphilic dendrons designed and synthesized showed excellent antimicrobial activities, depending highly on the length of the hydrophobic alkyl chain. The identified prime candidate exhibited rapid and broad-spectrum bactericidal activity, disrupting the integrity of a pathogen's membrane and promoting wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Polymer Science
Aleksei I. Ryzhkov, Fedor V. Drozdov, Georgij V. Cherkaev, Aziz M. Muzafarov
Summary: In this work, carbosilane dendrons were synthesized based on the natural terpenoid limonene, allowing the preservation of its double bond while acting as the growth center. The selectivity of hydrosilylation and hydrothiolation reactions resulted in the formation of carbosilane dendrons with specific structures. This synthesis method opens up wide possibilities for obtaining various macromolecules.
Article
Biochemical Research Methods
Brant D. Gates, Jackson B. Vyletel, Lei Zou, Matthew J. Webber
Summary: Certain supramolecular motifs, such as Cucurbit[7]uril (CB[7]) macrocycles, exhibit affinities comparable to well-known biological interactions. By modifying cells with CB[7] constructed from a polyamidoamine (PAMAM) dendrimer scaffold, guest-linked drugs can be delivered to the cell membrane, offering potential applications in biomedicine. This approach has the potential to be used for in situ imaging, modulation of cell-based therapies, or the construction of synthetic supramolecular recognition axis on the cell membrane.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Changren Liu, Ruonan Wang, Ying Sun, Changfeng Yin, Zhewei Gu, Wei Wu, Xiqun Jiang
Summary: This study presents a new strategy for synthesizing scaffold-modifiable dendrons via orthogonal amino protection and solid-phase synthesis method. The dendrons exhibit super selectivity, high reactivity, and wide applicability to various reaction types, making them an ideal choice for site-specific bifunctionalization. The dendron-based prodrug, conjugated with doxorubicin (DOX) and phenylboronic acid (PBA) groups, shows extraordinary antitumor efficacy and can eradicate tumors established in mice. This work provides a practical strategy for synthesizing scaffold-modifiable dendrons and offers a promising nanoplatform for function integration in a precisely controlled manner.
ACS CENTRAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zhibo Yu, Nicolas Tsapis, Francois Fay, Liang Chen, Andrii Karpus, Xiangyang Shi, Catherine Cailleau, Samuel Garcia Perez, Nicolas Huang, Juliette Vergnaud, Serge Mignani, Jean-Pierre Majoral, Elias Fattal
Summary: Small interfering RNA (siRNA) shows potential in treating rheumatoid arthritis by inhibiting major cytokines like tumor necrosis factor-alpha (TNF-alpha). Researchers have developed original cationic amphiphilic phosphorus dendrons that can form dendriplexes with TNF-alpha siRNA. These dendriplexes protect siRNA from degradation and enhance macrophage uptake, leading to significant inhibition of TNF-alpha expression and anti-inflammatory effects in in vitro and in vivo models. This opens up important perspectives for using these original amphiphilic dendrons in chronic inflammatory diseases.
Review
Biochemistry & Molecular Biology
Iwona Nierengarten, Michel Holler, Marine Remy, Uwe Hahn, Aurelien Billot, Robert Deschenaux, Jean-Francois Nierengarten
Summary: Pillar[5]arenes with ten peripheral substituents are attractive scaffolds for constructing nanomaterials with controlled functional groups distribution. This review focuses on functionalizing pillar[5]arene derivatives with small dendrons to create dendrimer-like nanomaterials and bioactive compounds, such as non-viral gene vectors, bioactive glycoclusters, and liquid-crystalline materials.
Article
Multidisciplinary Sciences
P. Lopez-Barona, C. Verdu-Exposito, T. Martin-Perez, N. Gomez-Casanova, T. Lozano-Cruz, P. Ortega, R. Gomez, J. Perez-Serrano, I Heredero-Bermejo
Summary: This study demonstrates a novel treatment strategy for Acanthamoeba keratitis, showing that different generations of cationic carbosilane dendrons derived from 4-phenylbutyric acid and the combination of chlorhexidine digluconate have amoebicidal activity against Acanthamoeba trophozoites and cysts.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Virgil Percec, Shitao Wang, Ning Huang, Benjamin E. Partridge, Xuefeng Wang, Dipankar Sahoo, David J. Hoffman, Jagadeesh Malineni, Mihai Peterca, Ryan L. Jezorek, Na Zhang, Hina Daud, Paul D. Sung, Emily R. McClure, Se Lin Song
Summary: Our laboratory synthesized 30 phenolic acids and transformed them into self-assembling dendrons through a simple chemical reaction, resulting in a variety of supramolecular assemblies such as lamellar structures, helical columnar assemblies, and columnar organizations. These findings contribute to the understanding of complex self-organizing principles in synthetic and biological matter.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Veronica Iguarbe, Pilar Romero, Joaquin Barbera, Anabel Elduque, Raquel Gimenez
Summary: This study explores the rich self-assembly behavior achieved by grafting a pyrazole-derived platform at the focal point of poly(benzyl ether) dendrons, forming liquid crystals and supergels. The novel focal point shows a strong tendency to arrange wedge-shaped or cone-shaped dendrons into columnar arrangements via hydrogen bonding, leading to different luminescent properties.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Akash Thamarappalli, Chandana Sampath Kumara Ranasinghe, Junhyuk Jang, Mile Gao, Paul L. Burn, Emma V. Puttock, Paul E. Shaw
Summary: Dual emission light-emitting dendrimers with phosphorescent and TADF-based emissive mechanisms were prepared. The dendrimers showed solvatochromism and the TADF-based dendrons acted as an energy pool for emission from the phosphorescent core. The dendrimers exhibited balanced hole and electron mobilities and good electroluminescent efficiency in organic light-emitting diodes.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liju Raju, Sousa Javan Nikkhah, Matthias Vandichel, Eswaran Rajkumar
Summary: In this research, we designed and synthesized a series of novel bipyridine cored poly(benzyl-ether) dendrons containing tertiary butyl esters at their periphery. The molecular structures of the synthesized dendrons were characterized using NMR and mass spectrometry. We investigated the solvent dependent hydrodynamic size of the dendrons in DMSO and water using DLS experiments and analyzed the water contact angle of the dendrons. Molecular dynamics simulations were performed to understand the structure and solvation behavior of the dendrons at the atomistic level. The modeling results confirmed that DMSO is a better solvent than water for dendrons, resulting in a more unfolded molecular structure. Based on these results, these dendritic polymers are excellent candidates for multifunctional theranostics platforms.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Biomedical
Siyuan Xiang, Jessica Wagner, Thorsten Luckerath, Klaus Mullen, David Y. W. Ng, Jana Hedrich, Tanja Weil
Summary: Amphiphilic polyphenylene dendrons (APDs) have shown potential in interrupting Aβ assembly and reducing Aβ-cell interactions, by binding to the secondary structure of Aβ aggregates and inhibiting fibrillation while disassembling existing Aβ fibrils. APDs also demonstrate cellular uptake in endosomes, compatibility with endothelial and neuronal cells, and reduction of Aβ-induced neuron cytotoxicity in vitro, making them promising for inhibiting Aβ fibrillation in vivo and potentially developing therapeutic strategies for Alzheimer's disease.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhijun Guo, Guangyue Bai, Xize Zhan, Kelei Zhuo, Jianji Wang, Yujie Wang
Summary: A coassembly strategy for a supramolecular vector/drug was proposed, which uses biocompatible molecules to achieve pH-responsive and sustained release functions. The self-assembling behaviors of the components and the functions of the vector/drug were characterized. The results demonstrate that this coassembly method is a simple and effective approach.
Review
Chemistry, Multidisciplinary
Anne-Marie Caminade, Aurelien Hameau, Kathleen Moineau-Chane Ching, Cedric-Olivier Turrin
Summary: This review presents the synthesis of dendrons based on cyclotriphosphazene cores, with one function being a fluorescent group, and the five remaining functions used for growing the dendritic branches. The growing of the branches is carried out by a divergent method using a two-step process. Different fluorophores and terminal functions of the dendrons lead to various applications, including catalysis, material elaboration, transfection experiments, anti-cancer property study, and imaging related to the human immune system.
HELVETICA CHIMICA ACTA
(2023)
Article
Biophysics
Yannick Cremillieux, Roberto Salvati, Ursule Dumont, Noel Pinaud, Veronique Bouchaud, Stephane Sanchez, Stefan Gloeggler, Alan Wong
NMR IN BIOMEDICINE
(2018)
Article
Crystallography
Jean Guillon, Stephane Moreau, Vanessa Desplat, Marian Vincenzi, Noel Pinaud, Solene Savrimoutou, Sandra Rubio, Luisa Ronga, Filomena Rossi, Mathieu Marchivie
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
(2019)
Article
Neurosciences
Yannick Cremillieux, Ursule Dumont, Leslie Mazuel, Roberto Salvati, Vanessa Zhendre, Silvia Rizzitelli, Jordy Blanc, Helene Roumes, Noel Pinaud, Anne-Karine Bouzier-Sore
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yannick Cremillieux, Yoann Montigaud, Clemence Bal, Noel Pinaud, Vi Pham, Sophie Perinel, Marco Natuzzi, Francois Lux, Olivier Tillement, Nobuyasu Ichinose, Bei Zhang, Jeremie Pourchez
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Yoann Montigaud, Jeremie Pourchez, Lara Leclerc, Olivier Tillement, Anthony Clotagatide, Clemence Bal, Noel Pinaud, Nobuyasu Ichinose, Bei Zhang, Sophie Perinel, Francois Lux, Yannick Cremillieux, Nathalie Prevot
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Bruno Oyallon, Marie Brachet-Botineau, Cedric Loge, Thomas Robert, Stephane Bach, Sajida Ibrahim, William Raoul, Cecile Croix, Pascal Berthelot, Jean Guillon, Noel Pinaud, Fabrice Gouilleux, Marie-Claude Viaud-Massuard, Caroline Denevault-Sabourin
Summary: New quinoxaline derivatives acting as dual Pim1/2 inhibitors showed potent inhibition of Pim-1 and Pim-2 enzymes in vitro, and were able to inhibit the growth of multiple myeloma and colorectal carcinoma cell lines expressing high levels of Pim-1/2 kinases.
Article
Biochemistry & Molecular Biology
Justine Deborne, Noel Pinaud, Yannick Cremillieux
Summary: The study evaluated the potential of a miniaturized implantable NMR coil to acquire proton NMR spectra in sub-microliter regions of interest and to obtain metabolic information. Results showed that the designed implantable microcoil is suitable for in vivo MRS and can be used for probing the metabolism in localized and very small regions of interest in a tumor.
Article
Biophysics
Justine Deborne, Noel Pinaud, Yannick Cremillieux
Summary: Miniaturized NMR receiver coils are effective for improving detection sensitivity in MRS and MRI studies, especially in small volumes or regions of interest. Implantable microcoils showed a sensitivity gain of over 50 compared to external coils, with diagnostic proton spectra obtained from brain regions as small as a few hundred nanoliters. The minimally invasive nature of the coil implantation process was highlighted, making these microcoils new tools for probing tissue metabolism.
NMR IN BIOMEDICINE
(2021)
Article
Crystallography
Jean Guillon, Noel Pinaud, Solene Savrimoutou, Mathieu Marchivie, Stephane Moreau, Sandra Albenque-Rubio, Pascal Sonnet
Summary: The X-ray crystal structure analysis of the antimalarial compound revealed that each molecule forms tetramers through intermolecular N-H···Cl hydrogen bond interactions.
X-RAY STRUCTURE ANALYSIS ONLINE
(2021)
Article
Chemistry, Organic
Jean Guillon, Solene Savrimoutou, Sandra Albenque-Rubio, Noel Pinaud, Stephane Moreau, Vanessa Desplat
Summary: A new substituted pyrroloquinoxaline compound was synthesized and its structure was characterized using various analytical techniques. This compound exhibited interesting cytotoxic potential against multiple human leukemia cell lines.
Article
Radiology, Nuclear Medicine & Medical Imaging
Audrey Lavielle, Fabien Boux, Justine Deborne, Noel Pinaud, Sandrine Dufort, Camille Verry, Sylvie Grand, Irene Tropres, Clement Vecco-Garda, Geraldine Le Duc, Stephane Mornet, Yannick Cremillieux
Summary: This study aims to generate T1 maps from MR images using the MPRAGE sequence and evaluate its feasibility in phantoms, animal models, and patients with brain metastases. The results demonstrate that the MPRAGE sequence can be used as a method to measure the concentration of Gd-based theranostic agents within a standard clinical imaging protocol.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Chemistry, Organic
Jean Guillon, Solene Savrimoutou, Sandra Albenque-Rubio, Noel Pinaud, Nina Fillova, Stephane Moreau, Virginie Baylot, Vanessa Desplat
Summary: A new substituted pyrroloquinoxaline compound was designed, synthesized, and characterized in this study. The compound showed interesting cytotoxic potential against different human leukemia cell lines.
Article
Chemistry, Organic
Jean Guillon, Solene Savrimoutou, Sandra Rubio, Stephane Moreau, Noel Pinaud, Mathieu Marchivie, Vanessa Desplat
Article
Crystallography
Jean Guillon, Maria De Fatima Pereira-Rosenfeld, Noel Pinaud, Thierry Besson, Valerie Thiery, Laurent Picot, Mathieu Marchivie
X-RAY STRUCTURE ANALYSIS ONLINE
(2019)
Article
Chemistry, Medicinal
Vanessa Desplat, Marian Vincenzi, Romain Lucas, Stephane Moreau, Solene Savrimoutou, Sandra Rubio, Noel Pinaud, David Bigat, Elodie Enriquez, Mathieu Marchivie, Sylvain Routier, Pascal Sonnet, Filomena Rossi, Luisa Ronga, Jean Guillon