Article
Chemistry, Inorganic & Nuclear
Riccardo De Marco, Marco Dal Grande, Marco Baron, Laura Orian, Claudia Graiff, Thierry Achard, Stephane Bellemin-Laponnaz, Alexander Pothig, Cristina Tubaro
Summary: A series of gold complexes with N-heterocyclic carbene ligands functionalized with a pendant thioether group were synthesized and characterized, showing moderate in vitro cytotoxicity towards breast cancer cells MCF7. The experimental aspects were rationalized through relativistic DFT calculations.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Inga-Alexandra Bischoff, Bernd Morgenstern, Andre Schaefer
Summary: This study reports a new class of half-sandwich complexes consisting of group 14 elements germanium, tin and lead, which can form complexes with both carbenes and transition metal fragments, bridging the gap between classical N-heterocyclic systems and group 14 metallocenes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Manuel Schmitt, Maximilian Maylaender, Valentin Radtke, Tim Heizmann, Sabine Richert, Ingo Krossing
Summary: The stable and easily accessible salt [Ni(CO)(4)](+)[F{Al(ORF)(3)}(2)](-) was used as a Ni-I synthon to generate novel half-sandwich complexes [Ni(arene)(CO)(2)](+). The reaction with [Ni(o-dfb)(2)](+) salt, which has a rather endergonic reaction, was successful by removing CO irreversibly. The resulting complex has a unique slipped eta(3), eta(3)-sandwich structure and is the ultimate synthon for Ni-I chemistry.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Arpan Das, Soumi Chakraborty, Swadhin K. Mandal
Summary: Abnormal N-heterocyclic carbene (aNHC) based Ni(II) pi-allyl complexes (3 and 4) were synthesized from a Ni(0) precursor and characterized. The mechanism for the formation of Ni(II) eta(3)-allyl complexes from a Ni(0) precursor using a free abnormal N-heterocyclic carbene was elucidated. Exposure of complex 3 to O-2 gas under ambient pressure resulted in the activation of molecular oxygen to form a mu-hydroxo bridged Ni(II) dimer.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Thomas Scattolin, Andrea Piccin, Matteo Mauceri, Flavio Rizzolio, Nicola Demitri, Vincenzo Canzonieri, Fabiano Visentin
Summary: Newly synthesized palladium allyl complexes exhibit lower antiproliferative activity, with similar anticancer activity in two ovarian cancer cell lines, suggesting a different mechanism of action compared to platinum-based anticancer drugs. Some compounds show lower cytotoxicity on normal cells and higher selectivity towards cancer cells. Comparing the IC50 values of NHC/PTA complexes and their trifluoromethyl congeners indicates similar antiproliferative activity against cancer cells, but the absence of the CF3 group decreases selectivity towards them.
Article
Chemistry, Inorganic & Nuclear
Franck Ulm, Saurabh Shahane, Lai Truong-Phuoc, Thierry Romero, Vasiliki Papaefthimiou, Matthieu Chesse, Michael J. Chetcuti, Cuong Pham-Huu, Christophe Michon, Vincent Ritleng
Summary: The preparation of cationic nickel complexes with bidentate coordination and their activity in aldehyde reduction are studied. The nanoparticles involving NHC-picolyl-Ni are observed under specific conditions, showing potential applications in catalysis.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Abdollah Neshat, Rahimeh Khezri, Mohammad Reza Yousefshahi, Mohammad Gholinejad, Fahimeh Varmaghani
Summary: The synthesis and characterization of Nickel(II) complexes with novel pincer-type N-heterocyclic carbene complexes were investigated. The complexes showed high activity as catalysts for the coupling reactions of aryl and alkyl halides. By adjusting the steric hindrance of the ligand, better catalytic performance could be achieved. Under the experimental conditions, a catalyst loading as low as 5 mol% could yield high-productivity products.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yaru Jing, Jingxing Jiang, Yan Liu, Zhuofeng Ke
Summary: This study presents a theoretical evaluation of the electronic and steric properties of various N-Heterocyclic boryl (NHB) ligands using NHB-Ir(CO)(3) as the model complex. The results reveal the influence of substitution, backbone saturation, ring size, and heteroatoms on the NHB properties. The findings suggest that these scales are crucial for the design, application, and mechanistic understanding of NHB-based complexes or molecules.
Article
Chemistry, Inorganic & Nuclear
Sangeeta Kumari, Charu Sharma, Avinash K. Srivastava, Naveen Satrawala, Kamal N. Sharma, Raj K. Joshi
Summary: A Ru(II) complex was synthesized for C-H bond activation alkenylation of arenes using thioether directing groups, achieving high yields under milder conditions compared to previous methods utilizing precious noble metal catalysts. Broad substrate scope was demonstrated with good tolerance towards benzyl thioethers and vinyl, making it the first report of its kind utilizing a Ru-based catalyst for thioether alkenylation.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Rajendra S. Ghadwal
Summary: This review article aims to highlight recent advances in accessing stable iMICs, quantifying their properties, and exploring their applications in synthesis and catalysis. The synthetic viability and use of vicinal C4,C5-anionic dicarbenes (ADCs) based on a 1,3-imidazole framework are also presented. iMICs and ADCs have the potential to push the limit of classical NHCs by enabling access to conceptually new main-group heterocycles, radicals, molecular catalysts, ligand sets, and more.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Niklas F. Both, Anke Spannenberg, Haijun Jiao, Kathrin Junge, Matthias Beller
Summary: The use of bis(NHC) manganese(I) complexes 3 as catalysts for the hydrogenation of esters was investigated. Various aromatic and aliphatic esters were successfully hydrogenated at mild temperatures and low catalyst loadings using complexes 3 with KHBEt3 as additive, highlighting the efficiency of the novel catalytic system. Additionally, the versatility of the developed catalytic system was demonstrated by the hydrogenation of other substrate classes like ketones, nitriles, N-heteroarenes, and alkenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joel Poupon, Jerome Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-Francois Betzer, Angela Marinetti, Sophie Bombard
Summary: This article introduces a new series of bimetallic platinum-(II) complexes with NHC-type bridging ligands, which exhibit cytotoxicity, cell accumulation, and DNA binding properties in cancerous cells. These complexes demonstrate significant radiosensitizing effects by inhibiting DNA repair mechanisms, leading to persistent accumulation of irradiation-induced DNA damages. This study provides the first in vitro evidence for the radiosensitizing properties of NHC-platinum complexes, suggesting their potential use in combined chemo-radiotherapy protocols.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Fady Nahra, Nikolaos Tzouras, Alba Collado, Steven P. Nolan
Summary: N-heterocyclic carbene gold(I) chloride and hydroxide complexes are commonly used as synthetic reagents and efficient catalysts. This study describes a straightforward and practical method for synthesizing mononuclear gold complexes with high yields, as well as the synthesis of a mononuclear gold(I) hydroxide complex and an improved synthesis method for a dinuclear gold(I) hydroxide complex. This methodology offers advantages such as the use of sustainable reaction solvents and commercially available starting materials.
Review
Chemistry, Inorganic & Nuclear
Yidan Wang, Bo Zhang, Shuai Guo
Summary: The combination of NHC and pincer framework in transition metal complexes has been widely studied and applied in various fields, including catalysis and optical material chemistry. This minireview focuses on the synthesis, reactivity study and applications of metal pincer NHCs.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Guenther Horrer, Martin S. Luff, Udo Radius
Summary: The synthesis and characterization of a series of Cr(II) N-Heterocyclic Carbene (NHC) complexes were reported. The study also investigated the cyclic NHC ligated complexes and confirmed the presence of chromium centered radicals in certain complexes through quantum chemical calculations.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Ruud Peters, Ingrid Elbers, Anna Undas, Eelco Sijtsma, Sophie Briffa, Pauline Carnell-Morris, Agnieszka Siupa, Tae-Hyun Yoon, Loic Burr, David Schmid, Jutta Tentschert, Yves Hachenberger, Harald Jungnickel, Andreas Luch, Florian Meier, Jovana Kocic, Jaeseok Kim, Byong Chon Park, Barry Hardy, Colin Johnston, Kerstin Jurkschat, Joerg Radnik, Vasile-Dan Hodoroaba, Iseult Lynch, Eugenia Valsami-Jones
Summary: The ACEnano project aims to develop, optimize, and validate methods for detecting and characterizing nanomaterials through interlaboratory comparisons. Results show that laboratories are capable of accurately determining particle sizes of nanomaterials, but variations can occur in complex matrices or formulations.
Review
Biochemistry & Molecular Biology
Vincent Ritleng, Johannes G. de Vries
Summary: This review focuses on the synthesis and application of ruthenacycles and iridacycles in hydrogen transfer reactions, specifically in (asymmetric) transfer hydrogenation of aldehydes, ketones, and imines, as well as some oxidation reactions.
Article
Chemistry, Multidisciplinary
Nils Ulrich, Anne Spende, Loic Burr, Nicolas Sobel, Ina Schubert, Christian Hess, Christina Trautmann, Maria Eugenia Toimil-Molares
Summary: Etched ion-track polycarbonate membranes with conical nanochannels coated with Al2O3, TiO2, and SiO2 thin films by ALD are used to fabricate two functional structures: arrays of free-standing conical nanotubes for drug delivery and wettability regulation, and single nanochannel membranes for nanofluidic applications with adjustable isoelectric points.
Article
Biotechnology & Applied Microbiology
Florian Ponzio, Julien Kelber, Laura Birba, Kamal Rekab, Vincent Ritleng, Loic Jierry, David Edouard
Summary: Polyurethane foams have a potential application in photocatalysis but require a polydopamine film coating to enhance their photostability. Functionalized foams loaded with TiO2 particles can efficiently degrade formic acid in water and the mineralization of acetaldehyde, n-heptane, toluene, and acetone in air.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Biochemistry & Molecular Biology
Joerg Radnik, Vasile-Dan Hodoroaba, Harald Jungnickel, Jutta Tentschert, Andreas Luch, Vanessa Sogne, Florian Meier, Loic Burr, David Schmid, Christoph Schlager, Tae Hyun Yoon, Ruud Peters, Sophie M. Briffa, Eugenia Valsami-Jones
Summary: While the characterization of nanomaterials using analytical techniques is well-automated, the manual sample preparation process poses a bottleneck in nanomaterial analysis. This article discusses solutions to address this issue in nano-analytics and presents two case studies on automation in sample introduction and analysis of biological samples. The results demonstrate that standardization and automation of sample preparation setups, combined with appropriate measurement processes and data reduction, are crucial for obtaining reliable and reproducible data.
Article
Chemistry, Analytical
Safiye Jafari, Loic Burr, Davide Migliorelli, Roger Galve, M. Pilar Marco, Katrina Campbell, Chris Elliott, Michele Suman, Shana J. Sturla, Silvia Generelli
Summary: Considering the complexities and speed of modern food chains, there is an increasing demand for point-of-need detection of food contaminants, particularly highly regulated chemicals and carcinogens such as aflatoxin B1. We report a user-friendly smartphone-based magneto-immunosensor on carbon black modified electrodes for point-of-need detection of aflatoxin B1 in cereals. The assay demonstrated a low limit of detection and high reproducibility, and its applicability was validated on the basis of EU guidelines. An open-source android application, AflaESense, was designed to provide a simple interface for data analysis.
ANALYTICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Vincent Ritleng, Christophe Michon
Summary: This review focuses on the application of ruthenium complexes with bidentate donor-functionalized N-heterocyclic carbene ligands in catalyzing hydrogen transfer reactions, and discusses the effects of different donor atoms and carbene ligands on the transfer hydrogenation reactions. This research is important for improving the efficiency and selectivity of catalytic hydrogen transfer reactions.
Correction
Biochemistry & Molecular Biology
Ruud Peters, Ingrid Elbers, Anna Undas, Eelco Sijtsma, Sophie Briffa, Pauline Carnell-Morris, Agnieszka Siupa, Tae-Hyun Yoon, Loic Burr, David Schmid, Jutta Tentschert, Yves Hachenberger, Harald Jungnickel, Andreas Luch, Florian Meier, Jovana Kocic, Jaeseok Kim, Byong Chon Park, Barry Hardy, Colin Johnston, Kerstin Jurkschat, Joerg Radnik, Vasile-Dan Hodoroaba, Iseult Lynch, Eugenia Valsami-Jones
Article
Chemistry, Multidisciplinary
Marta G. Avello, Stephane Golling, Lai Truong-Phuoc, Loic Vidal, Thierry Romero, Vasiliki Papaefthimiou, Nathalie Gruber, Michael J. Chetcuti, Frederic R. Leroux, Morgan Donnard, Vincent Ritleng, Cuong Pham-Huu, Christophe Michon
Summary: This study demonstrates the successful synthesis of nickel(0) nanoparticles coordinated to NHC ligands bearing N-coordinated cinnamyl moieties. The unique ligand structure prevents aggregation of the nanoparticles into larger inactive species and enables effective and (Z)-selective semi-hydrogenation of alkynes and ynamides.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Inorganic & Nuclear
Han Peng, Vincent Ritleng, Christophe Michon
Summary: This article reviews the development of supported Noyori-Ikariya catalysts based on ruthenium, rhodium, and iridium for asymmetric transfer hydrogenation and related tandem reactions over the past 7 years. It highlights and discusses the synthesis, reactivity, and recycling of these catalysts.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Han Peng, Xiong Zhang, Vasiliki Papaefthimiou, Cuong Pham-Huu, Vincent Ritleng
Summary: The study shows a simple method to anchor Pd on a polydopamine-coated polyurethane foam, resulting in a single atom dispersion of the active phase. Pd@PDA@PUF exhibits high activity, selectivity, and reusability in alkyne semi-hydrogenation and Suzuki coupling reactions without prior reduction.
Article
Chemistry, Physical
Han Peng, Thierry Romero, Philippe Bertani, Vincent Ritleng
Summary: An easy-to-handle eosin Y-based heterogeneous photocatalyst was prepared by post-functionalization of a polydopamine-coated open cell polyurethane foam (PDA@PUF) via the silanization of the adhesive layer with 3-(triethoxysilyl)propan-1-amine (APTES) and the subsequent EDC-mediated coupling of the resulting amino-functionalized foam with eosin Y. The obtained macroscopic material, EY-APTES@PDA@PUF, showed good efficiency and excellent reusability for photocatalytic reactions. However, eosin Y leaching was observed during the oxidation of sulfides to sulfoxides, leading to a progressive deactivation of the catalytic foam.
Article
Chemistry, Physical
Han Peng, Thierry Romero, Vasiliki Papaefthimiou, Philippe Bertani, Vincent Ritleng
Summary: An easily operable, highly reusable, and efficient photocatalyst based on [Ru(bpy)3]2+ was obtained by post-functionalization of a polydopamine-coated open cell polyurethane foam (PDA@PUF). The functionalization process included silanization of the mussel-inspired adhesive layer with APTES, coupling with [2,2'-bipyridine]-4-carboxylic acid, and complexation with [Ru(bpy)2Cl2]. The photocatalyst showed excellent performance in benzylic amine homocouplings and cross dehydrogenative couplings under visible-light irradiation and molecular oxygen, with good functional group tolerance and reusability for at least six runs.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Caterina Minelli, Magdalena Wywijas, Dorota Bartczak, Susana Cuello-Nunez, Heidi Goenaga Infante, Jerome Deumer, Christian Gollwitzer, Michael Krumrey, Karen E. Murphy, Monique E. Johnson, Antonio R. Montoro Bustos, Ingo H. Strenge, Bertrand Faure, Peter Hoghoj, Vivian Tong, Loic Burr, Karin Norling, Fredrik Hook, Matthias Roesslein, Jovana Kocic, Lyndsey Hendriks, Vikram Kestens, Yannic Ramaye, Maria C. Contreras Lopez, Guy Auclair, Dora Mehn, Douglas Gilliland, Annegret Potthoff, Kathrin Oelschlagel, Jutta Tentschert, Harald Jungnickel, Benjamin C. Krause, Yves U. Hachenberger, Philipp Reichardt, Andreas Luch, Thomas E. Whittaker, Molly M. Stevens, Shalini Gupta, Akash Singh, Fang-hsin Lin, Yi-Hung Liu, Anna Luisa Costa, Carlo Baldisserri, Rid Jawad, Samir E. L. Andaloussi, Margaret N. Holme, Tae Geol Lee, Minjeong Kwak, Jaeseok Kim, Johanna Ziebel, Cedric Guignard, Sebastien Cambier, Servane Contal, Arno C. Gutleb, Jan Kuba Tatarkiewicz, Bartlomiej J. Jankiewicz, Bartosz Bartosewicz, Xiaochun Wu, Jeffrey A. Fagan, Elisabeth Elje, Elise Runden-Pran, Maria Dusinska, Inder Preet Kaur, David Price, Ian Nesbitt, Sarah O'Reilly, Ruud J. B. Peters, Guillaume Bucher, Dennis Coleman, Angela J. Harrison, Antoine Ghanem, Anne Gering, Eileen McCarron, Niamh Fitzgerald, Geert Cornelis, Jani Tuoriniemi, Midori Sakai, Hidehisa Tsuchida, Ciaran Maguire, Adriele Prina-Mello, Alan J. Lawlor, Jessica Adams, Carolin L. Schultz, Doru Constantin, Nguyen Thi Kim Thanh, Le Duc Tung, Luca Panariello, Spyridon Damilos, Asterios Gavriilidis, Iseult Lynch, Benjamin Fryer, Ana Carrazco Quevedo, Emily Guggenheim, Sophie Briffa, Eugenia Valsami-Jones, Yuxiong Huang, Arturo A. Keller, Virva-Tuuli Kinnunen, Siiri Peramaki, Zeljka Krpetic, Michael Greenwood, Alexander G. Shard
Summary: This study evaluates the repeatability and reproducibility of different measurement methods for the particle number concentration of colloidal nanoparticles. The results show that population-averaging methods have higher repeatability and reproducibility than particle-counting methods.
Article
Nanoscience & Nanotechnology
Ahmed Ait Khouya, Housseinou Ba, Walid Baaziz, Jean-Mario Nhut, Andrea Rossin, Spyridon Zafeiratos, Ovidiu Ersen, Giuliano Giambastiani, Vincent Ritleng, Cuong Pham-Huu
Summary: Researchers successfully prepared ultra-thin palladium nanosheets on carbon black grains under reductant-free conditions using ultrasonication. These composites exhibit excellent activity and selectivity in the selective alkyne-to-alkene hydrogenation reaction, while also reducing environmental risks.
ACS APPLIED NANO MATERIALS
(2021)
