Article
Chemistry, Applied
Wenli Bai, Jian Sun, Dongyang Wang, Sheng-Di Bai, Liang Deng
Summary: This study investigates the catalytic performance of low-coordinate cobalt(0) N-heterocyclic carbene (NHC) complexes in the hydrosilylation reaction of alkynes, revealing the fine selectivity mechanism governed by the steric nature of the NHC ligand.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Akin Mumcu, Mert Olgun Karatas, Namik Ozdemir, Ali Erdogan, Hasan Kucukbay
Summary: In this study, complexes [Ru(NHC)(p-cymene)Cl-2], [MCl(NHC)(cod)] (M=Rh or Ir), and [RhCl(NHC)(CO)(2)] have been synthesized and characterized. The catalytic activity of these complexes in hydrosilylation of terminal alkynes has been investigated. Among them, Ir-NHC exhibited high conversion rate and β-(Z) selectivity, while Rh-NHC showed β-(Z) selectivity initially but isomerized to β-(E) isomer after 24 hours. The results indicate the potential application of these complexes in catalytic reactions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Francis Bru, Mathieu Lesieur, Albert Poater, Alexandra M. Z. Slawin, Luigi Cavallo, Catherine S. J. Cazin
Summary: The synthesis and isolation of [Pd(NHC)(PhC equivalent to CPh)] complexes were reported, which are new 14-electron Pd(0)-complexes that serve as key synthons for known palladium(0) and palladium(II) species and allow access to unprecedented mixed NHC-phosphite palladium(0) complexes. These complexes are also capable of catalyzing the facile hydrosilylation of allenes. DFT calculations provided insights into the relatively weak interaction between the metal and the diphenylacetylene ligand, comparing it with other ligands with varying coordinating power, structure, and electronic properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Applied
Xinyu Du, Xinghao Qi, Kai Li, Xiaoyan Li, Hongjian Sun, Olaf Fuhr, Dieter Fenske
Summary: The novel silylene-supported iron hydride 1 was synthesized via C(sp(3))-H bond activation and exhibited excellent catalytic activity for hydrosilylation of aldehydes and ketones. It showed good tolerance and catalytic activity for substrates with different functional groups on the benzene ring, with both ketones and aldehydes being reduced in good to excellent yields under the same catalytic conditions. A possible catalytic mechanism was proposed based on experiments and literature reports.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Rajendra S. Ghadwal
Summary: This review article aims to highlight recent advances in accessing stable iMICs, quantifying their properties, and exploring their applications in synthesis and catalysis. The synthetic viability and use of vicinal C4,C5-anionic dicarbenes (ADCs) based on a 1,3-imidazole framework are also presented. iMICs and ADCs have the potential to push the limit of classical NHCs by enabling access to conceptually new main-group heterocycles, radicals, molecular catalysts, ligand sets, and more.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Lakshay Kathuria, Ashoka G. Samuelson
Summary: The enantioselective reduction of imines to chiral secondary amines was studied using chiral half-sandwich iridium complexes with N-heterocyclic carbene ligands. The optimized conditions showed good yields for ketimines with moderate enantiomeric excess. The Ir complex with phenylglycine-derived chiral NHC exhibited the highest catalytic activity and enantiomeric excess compared to other NHCs in the series.
Article
Chemistry, Multidisciplinary
Niklas F. Both, Anke Spannenberg, Haijun Jiao, Kathrin Junge, Matthias Beller
Summary: The use of bis(NHC) manganese(I) complexes 3 as catalysts for the hydrogenation of esters was investigated. Various aromatic and aliphatic esters were successfully hydrogenated at mild temperatures and low catalyst loadings using complexes 3 with KHBEt3 as additive, highlighting the efficiency of the novel catalytic system. Additionally, the versatility of the developed catalytic system was demonstrated by the hydrogenation of other substrate classes like ketones, nitriles, N-heteroarenes, and alkenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Pamela V. S. Nylund, Baptiste Monney, Christoph Weder, Martin Albrecht
Summary: The use of N-heterocyclic carbene (NHC) iron complexes as catalysts for the polymerization of lactide shows promising results, with high molecular weight, narrow dispersity, and high polymerization rate constant. The robustness of the catalyst makes it suitable for large-scale industrial applications.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Franck Ulm, Saurabh Shahane, Lai Truong-Phuoc, Thierry Romero, Vasiliki Papaefthimiou, Matthieu Chesse, Michael J. Chetcuti, Cuong Pham-Huu, Christophe Michon, Vincent Ritleng
Summary: The preparation of cationic nickel complexes with bidentate coordination and their activity in aldehyde reduction are studied. The nanoparticles involving NHC-picolyl-Ni are observed under specific conditions, showing potential applications in catalysis.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Mert Olgun Karatas, Tuba Keskin, Namik Ozdemir, Hasan Kucukbay, Suat Tekin, Ahmet Mansur, Selami Gunal, Suleyman Sandal
Summary: In this study, Ag, Rh, and Ir complexes of a silyl-substituted NHC ligand were synthesized and their biological properties were investigated. The results showed that these complexes exhibited comparable or better cytotoxicity against cancer cells and antimicrobial activity compared to standard drugs.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Louis Monsigny, Anna Kajetanowicz, Karol Grela
Summary: This review discusses a distinct class of ruthenium olefin metathesis catalysts with unsymmetrical N-heterocyclic carbene (uNHC) ligands, highlighting their advantages such as thermodynamic stability, chemical latency, selectivity, and compatibility with green solvents in specialized metathesis transformations. Despite being niche, uNHC complexes have the potential to be implemented in various industrial processes like valorization of Fischer-Tropsch olefin fractions, ethenolysis of renewable products, and modern pharmaceutical production.
Article
Chemistry, Inorganic & Nuclear
Lingyu Kong, Yajie Chou, Muriel Albalat, Marion Jean, Nicolas Vanthuyne, Stephane Humbel, Paola Nava, Herve Clavier
Summary: The concept of atropisomeric N-heterocyclic carbene (NHC)-metal complexes with C-2-symmetry was extended to palladium-based complexes. Through a comprehensive study of NHC precursors and screening of various NHC ligands, the formation of meso complexes was successfully circumvented. Eight atropisomeric NHC-palladium complexes were prepared and obtained with high enantiopurities through efficient chiral HPLC resolution. These complexes demonstrated good activity in the intramolecular alpha-arylation of amides, leading to the isolation of cyclic products with excellent enantioselectivities (up to 98% ee).
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Arpan Das, Soumi Chakraborty, Swadhin K. Mandal
Summary: Abnormal N-heterocyclic carbene (aNHC) based Ni(II) pi-allyl complexes (3 and 4) were synthesized from a Ni(0) precursor and characterized. The mechanism for the formation of Ni(II) eta(3)-allyl complexes from a Ni(0) precursor using a free abnormal N-heterocyclic carbene was elucidated. Exposure of complex 3 to O-2 gas under ambient pressure resulted in the activation of molecular oxygen to form a mu-hydroxo bridged Ni(II) dimer.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Physical
Konrad Stesik, Adrian Franczyk, Agnieszka Czapik, Ireneusz Kownacki, Jedrzej Walkowiak
Summary: Iridium(I) complexes with phosphorus(III) ligands possessing naturally occurring menthol units were synthesized and characterized. These complexes showed excellent catalytic activity and high tolerance in the hydrosilylation reactions of various carbonyl compounds. The obtained products were subsequently hydrolyzed, resulting in the formation of diverse alcohols and aldehydes useful in organic synthesis.
Article
Chemistry, Multidisciplinary
Hui Shen, Zhen Xu, Maryam Sabooni Asre Hazer, Qingyuan Wu, Jian Peng, Ruixuan Qin, Sami Malola, Boon K. Teo, Hannu Hakkinen, Nanfeng Zheng
Summary: Deciphering the atomic arrangement of hybrid surface ligands on metal nanoparticles is a key step towards understanding their complex geometrical and electronic structures, which can have potential bio-applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Oncology
David A. Drew, Allen Mo, James J. Grady, Richard G. Stevens, Joel B. Levine, Bruce M. Brenner, Joseph C. Anderson, Faripour Forouhar, Michael J. O'Brien, Thomas J. Devers, Daniel W. Rosenberg
MOLECULAR CANCER RESEARCH
(2018)
Article
Oncology
Allen Mo, Rong Wu, James P. Grady, Matthew P. Hanley, Margaret Toro, Helen Swede, Thomas J. Devers, Terryl J. Hartman, Daniel W. Rosenberg
CANCER CAUSES & CONTROL
(2018)
Article
Oncology
William S. Chen, Ranjit S. Bindra, Allen Mo, Thomas Hayman, Zain Husain, Joseph N. Contessa, Stephen G. Gaffney, Jeffrey P. Townsend, James B. Yu
FRONTIERS IN ONCOLOGY
(2018)
Article
Chemistry, Inorganic & Nuclear
Linh Le, Jiachen Liu, Tianyi He, Daniel Kim, Eric J. Lindley, Tia N. Cervarich, Jack C. Malek, John Pham, Matthew R. Buck, Anthony R. Chianese
Article
Chemistry, Inorganic & Nuclear
Linh Le, Jiachen Liu, Tianyi He, Jack C. Malek, Tia N. Cervarich, John C. Buttner, John Pham, Jason M. Keith, Anthony R. Chianese
Article
Chemistry, Multidisciplinary
Tianyi He, John C. Buttner, Eamon F. Reynolds, John Pham, Jack C. Malek, Jason M. Keith, Anthony R. Chianese
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Otorhinolaryngology
Arielle G. Thal, Bradley A. Schiff, Yasmina Ahmed, Angela Cao, Allen Mo, Vikas Mehta, Richard V. Smith, Hillel W. Cohen, Thomas J. Ow
Summary: Performing tracheotomy in patients with COVID-19 carries a risk of transmission to the surgical team, but the study found that with the use of standard personal protective equipment, the risk of transmission to surgical providers was minimal. Timing of tracheotomy following onset of symptoms may require further study to determine its impact on transmission risk.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Allen Mo, Julie Chung, Jeremy Eichler, Sarah Yukelis, Sheldon Feldman, Jana Fox, Madhur Garg, Shalom Kalnicki, Nitin Ohri, Joseph A. Sparano, Jonathan Klein
Summary: The study revealed a significant disruption in breast cancer survivorship follow-up during the COVID-19 pandemic, with younger patients, those receiving adjuvant radiation therapy, and those with lower household income more likely to continue follow-up during the pandemic.
Article
Chemistry, Inorganic & Nuclear
Fallyn L. Kirlin, Olivia J. Borden, Marianna C. Head, Sophie E. Kelly, Anthony R. Chianese
Summary: In recent years, the metal-catalyzed hydrogenolysis of epoxides to produce alcohols has made rapid progress, with some catalysts selectively giving linear or branched products. We report the highly active nature of PNN- and PNP-ruthenium pincer complexes containing N-H functional groups for the branched-selective hydrogenolysis of epoxides. The use of isopropyl alcohol as a solvent allows for excellent yields of branched alcohol products without the need for strongly basic additives, with catalyst loadings as low as 0.03%. The selectivity for branched products is very high for epoxides containing a directly attached secondary carbon, and the branched:linear ratios for aryl-substituted epoxides vary from 2.7 to 19.0. PNP-Ru catalysts exhibit a greater preference for branched products than PNN-Ru catalysts for aryl epoxides, and substrates with electron-rich aryl substituents show a lower preference for branched products.
Article
Oncology
Allen Mo, Christian Velten, Julie M. Jiang, Justin Tang, Nitin Ohri, Shalom Kalnicki, Parsa Mirhaji, Kei Nemoto, Boudewijn Aasman, Madhur Garg, Chandan Guha, N. Patrik Brodin, Rafi Kabarriti
Summary: This study aimed to develop a machine learning model for treatment recommendation in HCC patients previously treated with TACE. The results showed that additional treatment in line with the model recommendations significantly improved progression-free survival.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Marianna C. Head, Benjamin T. Joseph, Jason M. Keith, Anthony R. Chianese
Summary: The homogeneous catalysis of epoxide hydrogenolysis to give alcohols has been extensively studied. Catalyst systems have been developed for the selective formation of either branched or linear alcohol products. The proposed mechanisms of epoxide ring-opening involve cooperative C-O bond hydrogenolysis, but a new study suggests that the previously proposed bifunctional pathway is energetically inaccessible for ruthenium catalysts.
Article
Oncology
Julie M. Jiang, Jeremy Eichler, William Bodner, Jana Fox, Madhur Garg, Ra fi Kabarriti, Allen Mo, Shalom Kalnicki, Keyur Mehta, Amanda Rivera, Justin Tang, Johnny Yap, Nitin Ohri, Jonathan Klein
Summary: The purpose of this study was to explore the association between financial toxicity (FT) and cancer patients undergoing concurrent, definitive chemoradiation therapy (CRT). Prospective data from three trials were reviewed, and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire Core-30 was used to assess FT during CRT. The results showed that most patients reported FT before starting definitive treatment, suggesting that it should be assessed and addressed early in the cancer journey.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Bryn K. Werley, Xintong Hou, Evan P. Bertonazzi, Anthony Chianese, Timothy W. Funk
Summary: This study investigated the effect of cyclopentadienone electronics on the catalytic activity of (tetraarylcyclopentadienone)iron tricarbonyl compounds in transfer hydrogenations and dehydrogenations. The results showed that increasing the cyclopentadienone electron density enhanced the rates of both reactions. The study also proposed a trimethylamine-ligated compound as the primary catalyst resting state in dehydrogenations.
Article
Chemistry, Multidisciplinary
John Pham, Cole E. Jarczyk, Eamon F. Reynolds, Sophie. E. Kelly, Thao Kim, Tianyi He, Jason M. Keith, Anthony R. Chianese
Summary: The study demonstrates that the ruthenium catalyst for ester hydrogenation is activated through dehydroalkylation of the pincer ligand, supporting a proposed catalytic mechanism involving the NHEt-substituted derivative. Experimental results show a first-order dependence on ruthenium and hydrogen concentrations, saturation behavior in ester concentration, and inhibition by the product alcohol. The findings are in good agreement with DFT calculations and crystallographically characterized catalytic intermediates.
Article
Oncology
Bo-young Hong, Takayasu Ideta, Bruno S. Lemos, Yuichi Igarashi, Yuliana Tan, Michael DiSiena, Allen Mo, John W. Birk, Faripour Forouhar, Thomas J. Devers, George M. Weinstock, Daniel W. Rosenberg
NPJ PRECISION ONCOLOGY
(2019)