Review
Chemistry, Multidisciplinary
Sebastian C. Cosgrove, Ashley P. Mattey
Summary: The use of flow reactors in biocatalysis has increased significantly in recent years, with chemists designing flow systems that allow enzymes to go beyond the limitations of batch reactions. There is a growing trend towards fully continuous systems, with flow chemistry being seen as an enabling technology for automated synthesis. Advances in AI-assisted enzyme design have opened up the possibility of fully automating the development and implementation of continuous biocatalytic processes, leading to significant improvements in enzyme processes for synthesis.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Engineering, Chemical
Jia Wei Chew, W. Casey Q. LaMarche, Ray A. Cocco
Summary: As we celebrate the 100th anniversary of the commercialization of the fluidized bed reactor, it is evident that fluidized bed technology has undergone significant advancements in the past century. With the development of sophisticated models, experimentation techniques, and statistical tools, as well as the utilization of computational platforms and AI, the application of fluidized bed technology is expected to become more cost-effective and efficient.
Article
Chemistry, Physical
David Roura Padrosa, Zoya Nisar, Francesca Paradisi
Summary: Transaminases are important biocatalysts for amine production, but their stability remains a concern. Recycling systems for the amino donor can help push unfavourable equilibrium reactions and reduce the need for high amino donor concentrations.
Article
Energy & Fuels
Mathias Jacobs, Glen Meir, Amer Hakki, Leen C. J. Thomassen, Simon Kuhn, M. Enis Leblebici
Summary: Micro-photoreactors have a high surface-area-to-volume ratio and enable homogeneous illumination and high apparent reaction rate. However, their small size limits their use in industry. This study presents a scalable photoreactor design based on translucent monoliths, which can handle large throughputs while maintaining the benefits of microreactors.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2022)
Article
Engineering, Petroleum
Hasan Al-Ibadi, Karl Stephen, Eric Mackay
Summary: Modeling low-salinity waterflooding at the reservoir scale presents challenges due to numerical dispersion, but two new upscaling methods improve accuracy by adjusting effective salinity range and using derived pseudorelative permeability curves. Both methods show promising results in heterogeneous reservoirs.
Article
Multidisciplinary Sciences
Qiang Chen, Ge Qu, Xu Li, Mingjian Feng, Fan Yang, Yanjie Li, Jincheng Li, Feifei Tong, Shiyi Song, Yujun Wang, Zhoutong Sun, Guangsheng Luo
Summary: This study presents a feasible strategy utilizing the synergistic bridging of triazoles and metal ions to induce the formation of porous enzyme-assembled hydrogels with increased activity, which overcomes the limitations of low specific activity and poor stability in the industrial applications of immobilized enzymes.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Organic
Alexander Leslie, Angel Maria Joseph, Marcus Baumann
Summary: This review provides an overview of the current uptake of continuous flow techniques for various functional group interconversion reactions, highlighting prominent examples and exploring specific reaction classes. Readers will find a solid foundation of important transformations and further references to appreciate the opportunities arising from modern synthesis technologies such as flow synthesis.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Guillermo Garcia-Marquina, Judith Langer, Mercedes Sanchez-Costa, Gonzalo Jimenez-Oses, Fernando Lopez-Gallego
Summary: This study focuses on optimizing the continuous synthesis of simvastatin by immobilizing an engineered acyltransferase enzyme on controlled porous glass particles functionalized with Fe3+-catechol complexes. The immobilized enzyme showed improved thermal stability and maintained high product yield during multiple operational cycles. Under optimal flow conditions, the system achieved a 100% simvastatin yield with improved reaction mass efficiency and atom economy compared to previous studies.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Biochemical Research Methods
Yuhong Mao, Rong Fan, Renkuan Li, Xiuyun Ye, Ulrich Kulozik
Summary: The application of monolithic materials as carriers for enzymes has expanded to enable flow-through analysis and bioconversion processes, attributed to the absence of diffusion limitations in many monolith-based enzyme reactors. Polymer monoliths, in particular, are attractive as enzyme carriers due to the ease of introducing functional groups. This review summarizes the motivation behind developing enzymatic reactors using polymer monoliths and discusses the crucial characteristics and processing parameters affecting the performance of these reactors.
Article
Chemistry, Multidisciplinary
Dominik Polterauer, Dominique M. Roberge, Paul Hanselmann, Petteri Elsner, Christopher A. Hone, C. Oliver Kappe
Summary: This article discusses the development of ozonolysis reactions within a dedicated microreactor platform and presents the optimization conditions for the ozonolysis of cyclohexene and thioanisole. The research demonstrates that under specific conditions, ozonolysis reactions can achieve high yields and selectivity.
REACTION CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Nuli Xie, Mingqiang Li, Yue Wang, Hui Lv, Jiye Shi, Jiang Li, Qian Li, Fei Wang, Chunhai Fan
Summary: DNA logic circuits based on DNA molecular programming are used to implement specific algorithms using dynamic reaction networks. We have developed a compact yet efficient architecture using cooperative strand displacement reactions to construct a DNA full adder. By exploiting a parity-check algorithm, we were able to reduce the complexity of the circuit significantly compared to conventional designs and demonstrate the implementation of a 6-bit adder comparable in scale to an electronic chip.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Environmental
Kirandeep K. Gill, Rachel Gibson, Kam Ho Chester Yiu, Patrick Hester, Nuno M. Reis
Summary: The study compared the performance of capillary reactors with different diameters in continuous flow reactions, and found that using multiple parallel small-bore capillaries is a more effective strategy than increasing the diameter of a single large bore, achieving more ideal flow characteristics.
CHEMICAL ENGINEERING JOURNAL
(2021)
Editorial Material
Chemistry, Physical
Hongli Zhu
Summary: The study demonstrates the pilot scale roll-to-roll synthesis of sulfonated poly(ether ether ketone) (SPEEK) membrane and the scaling up of zinc flow batteries (ZFBs) stack, showing a significant cost reduction from $500-1500 per square meter for Nafion membranes to $12 per square meter for SPEEK membranes. This cost reduction will drive the usage of flow battery systems in large-scale energy storage applications.
Article
Engineering, Chemical
Johan Nordstrand, Joydeep Dutta
Summary: The study focuses on flow distribution in desalination technologies and proposes design principles to reduce pressure drop and increase energy efficiency. Important principles include massive parallelism, open regions for symmetric flow distribution, and tailoring permeability of electrodes and spacers. By rerouting flow, a significant reduction in pressure drop and energy consumption can be achieved.
Review
Nanoscience & Nanotechnology
Jing Zhang, Na Jin, Ning Ji, Xinyi Chen, Yu Shen, Ting Pan, Lin Li, Sheng Li, Weina Zhang, Fengwei Huo
Summary: Researchers have been working on constructing cell-like structures to mimic transformations seen in cells, using micro/nano reactors to create different microenvironments for biological substances. MOF reactors, with their uniform pores, large surface area, and precise particle size control, have been increasingly utilized in enzymatic catalysis, sensing, and therapy applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
