Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 16, Issue 10, Pages 1591-1597Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op300119s
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Darifenacin is a potent and competitive M-3 selective receptor antagonist (M(3)SRA), and its hydrobromide salt (1) is the active ingredient of pharmaceutical formulations for oral treatment of urinary incontinence. The present work demonstrates an efficient, commercial manufacturing process for darifenacin hydrobromide (1).
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