Article
Pharmacology & Pharmacy
Haibo Zhu, Wenyan Wang, Chunjie Sha, Wei Guo, Chunmei Li, Fengjuan Zhao, Hongbo Wang, Wanglin Jiang, Jingwei Tian
Summary: The study characterizes the novel chemical entity toludesvenlafaxine hydrochloride dihydrate as a potential triple monoamine reuptake inhibitor with fast-acting antidepressant-like activity and therapeutic profile improvements including anhedonia and sexual function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Suresh Paudel, Eunae Kim, Anlin Zhu, Srijan Acharya, Xiao Min, Seung Hoon Cheon, Kyeong-Man Kim
Summary: This study identified the diverse effects of synthetic 4-benzylpiperidine carboxamides on serotonin, norepinephrine, and dopamine reuptake, as well as the critical structural features contributing to the selectivity of these molecules for each of the monoamine transporters. Additionally, the study found that specific residues on the compounds bound to the transporters and highlighted the functional role of a dopamine reuptake inhibitor in regulating dopamine D-2 receptor function.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Xiaohui Sun, Tian Wang, Lin Zhou, Ce Zhang, Fenghua Fu
Summary: The aim of this study was to investigate the effect of toludesvenlafaxine (Tdv), a reuptake inhibitor of serotonin, norepinephrine, and dopamine, on the neurological function in cerebral ischemic rats and the underlying mechanisms. The MCAO/R model was induced in rats and the neuroprotective effects of Tdv were evaluated by infarct size, Garcia test, and beam walking test. Tdv ameliorated cerebral ischemic injury through reducing neuronal apoptosis and increasing the expression of BDNF via the activation of CREB pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Sohvi Luukkonen, Erik Meijer, Giovanni A. Tricarico, Johan Hofmans, Pieter F. W. Stouten, Gerard J. P. van Westen, Eelke B. Lenselink
Summary: Protein kinases are a protein family with important roles in complex diseases. They have ATP binding sites that can be targeted to create multitarget drugs. Multitask deep learning models outperform single-task deep learning and tree-based models for protein kinase activity prediction.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Applied
Zihong Zhou, Yahui Feng, Yongbo Xu, Shuming Wu, Jingping Kou, Yanqing Hu, Meng Zhang, Weijian Ling, Lei Zhang, Zhongqing Wang
Summary: A robust and scalable synthesis for vilazodone was developed to avoid the formation of impurities under alcoholic conditions. By adjusting the functionality transformations, the process successfully prevented the generation of harmful impurities and was validated at a kilogram scale.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Chemistry, Applied
Biyue Lin, Jingping Kou, Shuming Wu, Xuerong Cai, Qingbo Xiao, Yinglong Li, Jian Hu, Jianbing Li, Zhongqing Wang
Summary: A novel and scalable process has been developed for the industrial synthesis of vadadustat, achieving a total yield of 49.1% with a purity of >99.5%. The process, optimized through various steps, has been demonstrated at kilogram scale and the impurity profile has been extensively studied and documented.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Chemistry, Applied
Hyung Wook Moon, Seung Jong Lee, Seong Hu Park, Se Gyo Jung, In A. Jung, Chang Hun Seol, Seung Woo Kim, Seon Mi Lee, Bogonda Gangganna, Seokhwi Park, Kee-Young Lee, Chang-Young Oh, Juyoung Song, Jaehun Jung, Ji Soo Heo, Kang Hee Lee, Hae Sol Kim, Won Taek Lee, Areum Baek, Hyunik Shin
Summary: The industrial-scale synthesis of eldecalcitol involves a series of reactions including selective protecting group manipulation, palladium-catalyzed cyclization, and C-H hydroxylation to provide the highly crystalline product.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Nanoscience & Nanotechnology
Zhang Chen, Yuwei Tang, Aiyan Ji, Liangmiao Zhang, Yanfeng Gao
Summary: This study analyzed the failure mechanism of VO2 nanoparticles at room temperature, designed a new formulation for VO2 nanocomposite coatings to improve weatherability, and developed a continuous roll-coating method for large-scale preparation.
ACS APPLIED NANO MATERIALS
(2021)
Article
Polymer Science
Hanji Wang, Huaxia Dong, Xianbin Liu, Ping Zhang
Summary: This study reports the synthesis and laboratory testing of a novel PSS-based inhibitor colloidal material, which shows superior migration capacity and inhibitor return performance compared to conventional PSS inhibitors.
Article
Engineering, Chemical
V. D. Zhuravlev, L. Ermakova
Summary: The study examined the conditions for producing composites using Solution Combustion Synthesis (SCS) from reaction solutions of aluminum and nickel nitrates with glycine. The concentration of reaction solutions was found to increase product yield and process productivity, while the presence of Al3+ cations in the reaction solutions was observed to reduce combustion reaction intensity. The phase composition of the materials changed during annealing, with the formation of gamma-Al2O3 and NiAl2O4 spinel at different temperatures.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Computer Science, Information Systems
Pradipta Ghosh, Jonathan Bunton, Dimitrios Pylorof, Marcos A. M. Vieira, Kevin Chan, Ramesh Govindan, Gaurav S. S. Sukhatme, Paulo Tabuada, Gunjan Verma
Summary: While most networks have long lifetimes, temporary network infrastructure is often useful for special events, pop-up retail, or disaster response. An instant IoT network is quickly constructed and dismantled, and we study the synthesis of such networks in urban settings. The synthesis problem involves complex constraints such as sensor coverage, line-of-sight visibility, and network connectivity, and the challenge lies in quickly scaling to large regions while producing cost-effective solutions. We explore different representations of the synthesis problem using SMC and MILP, and develop a hierarchical synthesis technique to tackle larger problem sizes.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2023)
Article
Chemistry, Applied
Simon Wagschal, Diego Broggini, Trung D. C. Cao, Pascal Schleiss, Kristian Paun, Jessica Steiner, Anna-Lena Merk, Joachim Harsdorf, Winfried Fiedler, Stefan Schirling, Sven Hock, Tobias Strittmatter, Jan Dijkmans, Ivan Vervest, Tim Van Hoegaerden, Brecht Egle, Matthew P. Mower, Zhi Liu, Zhiyong Cao, Xiaoning He, Lei Chen, Lei Qin, Hongyu Tan, Jun Yan, Nicolas Lucien Cuniere, Carolyn S. Wei, Venkata Vuyyuru, Rajaram Ayothiraman, Sundaramurthy Rangaswamy, Mohamed Jaleel, Rajappa Vaidyanathan, Martin D. Eastgate, Richard Klep, Cyril Benhaim, Ilse Vogels, Koen Peeters, Sebastien Lemaire
Summary: Anticoagulants are important for preventing and treating cardiovascular diseases caused by blood clots. Factor XIa (FXIa) inhibitors offer the potential to improve the safety profile of existing anticoagulants in high-risk patients. This study discusses the optimization of the synthesis route for a FXIa inhibitor, including improvements in key intermediate isolation and streamlining of various chemical steps, resulting in a 70% yield of the desired product.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Chemistry, Multidisciplinary
Sruti Mondal, Tanmoy Pain, Kasturi Sahu, Sanjib Kar
Summary: The new two-step methodology for porphyrin synthesis is cost-effective and easy to scale up, with reproducible yields ranging from 10-40%.
Article
Chemistry, Multidisciplinary
Alexander G. Kvashnin, Dmitry S. Nikitin, Ivan I. Shanenkov, Ilia V. Chepkasov, Yulia A. Kvashnina, Artur Nassyrbayev, Alexander A. Sivkov, Zhanar Bolatova, Alexander Ya. Pak
Summary: Comprehensive theoretical and experimental studies have led to the discovery of a new synthesis method for Hf-Ta-C coatings. By employing an evolutionary search for stable crystal structures and conducting selective large-scale experimental synthesis using a unique plasma dynamic experimental setup, the research team has achieved the selective synthesis of hafnium-tantalum carbide coatings with predefined properties. Notably, the study paves the way for the synthesis of a wide range of functional coatings composed of various carbides, including high-entropy carbides.
ADVANCED FUNCTIONAL MATERIALS
(2022)
