Article
Biochemistry & Molecular Biology
Thanh Truong Giang Ly, Jisoo Yun, Jong-Seong Ha, Yeon-Ju Kim, Woong-Bi Jang, Thi Hong Van Le, Vinoth Kumar Rethineswaran, Jaewoo Choi, Jae-Ho Kim, Sang-Hyun Min, Dong-Hyung Lee, Ju-Seok Yang, Joo-Seop Chung, Sang-Mo Kwon
Summary: The study found that etravirine can induce AGR2 degradation via autophagy, thereby reducing tumor proliferation and metastasis. In vitro experiments and a mouse model showed that the combination of etravirine and paclitaxel can significantly suppress cancer progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Green & Sustainable Science & Technology
Haohao Bian, Cheng Shen, Wanpeng Liu, Yu Bon Man, Ming Hung Wong, Peter Christie, Shengdao Shan, Minyan Wang, Jin Zhang
Summary: This article presents an improved co-pyrolysis method for synthesizing LDH/biochar composites. The method involves directly anchoring MgFe-LDH on corn stover through co-precipitation with FeCl3 and Mg(OH)(2), followed by pyrolysis. The improved method eliminates the need for pH control steps and achieves high LDH crystallinity and purity. The resulting composite exhibits enhanced properties such as higher loading of MgFe-LDH and larger specific surface area, making it highly efficient in selectively removing phosphorus from complex wastewaters.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Organic
Xuan Pan, Rui Yu, Zhanzhu Liu
Summary: This improved approach for synthesizing griseofamine A from L-4-bromo tryptophan methyl ester in 5 steps with a yield of 28% is more efficient, convenient, and scalable.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Medicinal
Marieta Muresan-Pop, Adriana Vulpoi, Viorica Simon, Milica Todea, Klara Magyari, Zsolt Pap, Andrea Simion, Claudiu Filip, Simion Simon
Summary: This study investigated the co-crystals formation of etravirine with three carboxylic acids. New co-crystals of etravirine with adipic acid, benzoic acid, and 4-hydroxybenzoic acid were synthesized by wet milling and their novelty and different morphology were confirmed by various analyses. The wet milling process resulted in a reduction in fusion enthalpy and melting temperature of the co-crystals. These co-crystals showed stability during storage, except for the co-crystal with benzoic acid. UV absorption spectra revealed conformational changes of etravirine due to hydrogen bonds with carboxylic acids.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Organic
Yuvaraja RDibdalli, Rodrigo Faundez, Marcelo Preite, Elies Molins, Ivonne Chavez, Mungalimane K. Amshumali, Cesar Morales-Verdejo, Juan M. Manriquez
Summary: The contribution presents an updated synthetic route to 3,6-dihydro-as-indacene and characterization of all intermediates. The title compound is obtained through a series of reactions starting from 2-methylfuran, with the structure confirmed by X-ray diffraction.
SYNTHESIS-STUTTGART
(2021)
Article
Engineering, Chemical
Li Zhang, Yang Liu, Yongju Zhang
Summary: In this work, the principle of metamorphic mechanism is optimized for product design based on variable topological structures. A metamorphic element and a configuration synthesis strategy are proposed. Kinematic performances of source and developed mechanism configurations are compared, demonstrating successful synthesis of multiple types of metamorphic mechanisms and satisfaction of functional targets.
Article
Biochemistry & Molecular Biology
Gao Ran, Tian Weisheng
Summary: An improved synthesis of azedarachol was reported, achieving an overall yield of 12% from pregnanetriol in 10 steps. The proper use of p-anisaldehyde dimethyl acetal allowed for a regioselective reduction of 2-enepregnane-16R,20R-p-anisaldehyde acetal (6), enabling the selective protection of C16-hydroxy and a stereoselective reduction of the C20-ketone to establish the configuration at C20.
Article
Chemistry, Organic
Rachele Maschio, Federica Buonsanti, Federico Crivellin, Fulvio Ferretti, Luciano Lattuada, Federico Maisano, Laura Orio, Lorena Pizzuto, Raphael Campanella, Anthony Clouet, Camilla Cavallotti, Giovanni B. Giovenzana
Summary: Optical imaging is a non-invasive diagnostic imaging technology that utilizes fluorescent molecules emitting light in the near-infrared region to achieve tumor imaging. It has potential clinical applications.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Satish Rojekar, Lalitkumar K. Vora, Ismaiel A. Tekko, Fabiana Volpe-Zanutto, Helen O. McCarthy, Pradeep R. Vavia, Ryan F. Donnelly
Summary: The development of long-acting HIV therapy using dissolving microneedles loaded with etravirine nanosuspension shows potential for improving patient adherence through self-administration. Studies demonstrate higher deposition and efficacy compared to traditional intravenous solutions, suggesting promise for the future of HIV treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Viktor Barat, Anqi Chen, Yee Hwee Lim
Summary: An improved method for synthesizing both alpha- and beta-pseudouridines from a common intermediate has been developed. This practical approach involves a highly diastereoselective Grignard reaction using inexpensive protected D-ribose, followed by a one-pot, acid-mediated deprotection-cyclization and anomerization to obtain beta-pseudouridine, or a Mitsunobu cyclization and subsequent deprotection to obtain alpha-pseudouridine. Detailed H-1 NMR kinetic studies provide insights into the cyclization and anomerization steps.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Organic
Arvind Negi, Styliana I. Mirallai, Saidulu Konda, Paul V. Murphy
Summary: An optimized method for the synthesis of various triarylpyridines, including non-symmetric pyridines, with different aryl substituents was reported. The reaction involved sequential addition of two different acetophenones to benzylamine in the presence of copper (I) iodide, methanolic ammonia, and oxygen, resulting in good yields of the desired products.
Article
Medicine, General & Internal
Kavita Behara, Ernest Bhero, John Terhile Agee
Summary: This article introduces a skin lesion synthesis and classification model based on an Improved Deep Convolutional Generative Adversarial Network (DCGAN). The model can generate high-quality skin lesion images and accurately classify them. By using multiple convolutional neural networks and a series of image processing techniques, training the model becomes easier and it demonstrates superior performance.
Article
Biochemistry & Molecular Biology
Ana Donaire-Arias, Martin L. Poulsen, Jaime Ramon-Costa, Ana Maria Montagut, Roger Estrada-Tejedor, Jose I. Borrell
Summary: Chalcones, a type of molecule that can be easily synthesized through aldol condensation, lacks standard procedures and often yields low purity and low yields. By comparing aldol condensation and Wittig reaction, the improved procedure of Wittig reaction shows high yield and excellent purity, providing a novel method for the synthesis of chalcones.
Article
Chemistry, Analytical
Jiangtao Liu, Peng Tian, Hongru Li, Hao Wei, Guoliang Deng, Shouhuan Zhou, Zeyu Ma, Wenwu Wang, Liang He
Summary: An improved three-frequency heterodyne synthesis phase unwrapping method is proposed to improve measurement accuracy, reduce noise effects, and increase equivalent phase frequency. Otsu segmentation is introduced for phase threshold judging, and the appropriate period combinations are also studied.
Article
Biotechnology & Applied Microbiology
Pengchao Wang, Xiwen Zhang, Yucheng Tao, Xubing Lv, Shengjie Cheng, Chengwei Liu
Summary: An L-phg synthesis pathway was developed in Escherichia coli, resulting in increased L-phg production by introducing new enzymes, a cofactor self-sufficient system, and a protein scaffold.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2022)
Article
Metallurgy & Metallurgical Engineering
Suhas Sreekanth, Kjell Hurtig, Shrikant Joshi, Joel Andersson
Summary: This article provides a detailed study on the solution treatments and delta precipitation treatments carried out on laser-directed energy deposited alloy 718 specimens. The research shows that the process parameters greatly influence the delta precipitation, with different microstructural features observed under high and low energy conditions. The morphology and location of the delta phase precipitates studied in this research are crucial for designing the performance of alloy 718 built by DED process.
WELDING IN THE WORLD
(2022)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Rashmi Prava Das, Kamalakanta Muduli, Rakesh Raut, B. E. Narkhede, Himanshu Shee, Abhishek Misra
Summary: This study identifies critical factors to enhance the effectiveness of humanitarian activities during the COVID-19 pandemic. Building a blockchain-enabled digital network and using digital platforms for real-time information sharing are found to be the most significant factors.
Article
Materials Science, Multidisciplinary
Sribalaji Mathiyalagan, Matteo Rossetti, Stefan Bjorklund, Susanne Sowers, Timothy Dumm, Chung Kim, Shrikant Joshi
Summary: This study utilized high velocity air fuel spraying to develop high-performance large area tribological coatings of nickel phosphorus cladded cubic-boron nitride particles. The effects of different nozzle configurations and annealing on coating properties were investigated. The study also analyzed the wear mechanisms of the coatings and the impact of annealing on their performance.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Business
Manu Sharma, Anil Kumar, Sunil Luthra, Sudhanshu Joshi, Arvind Upadhyay
Summary: Digital supply chain networks and low-carbon practices have an impact on the sustainable performance of manufacturing firms, with the relationship being moderated by environmental dynamism.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2022)
Article
Information Science & Library Science
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar
Summary: This study examines the challenges of AI implementation in the Public Manufacturing Sector (PMS) of India and proposes a model for decision-makers and managers to develop intelligent AI enabled systems.
GOVERNMENT INFORMATION QUARTERLY
(2022)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar, Akshat Jain
Summary: The study aims to investigate the impact of green logistics on the adoption of Circular Economy (CE) in the era of Industry 4.0 (I4.0). By implementing green initiatives, the logistics sector shows its strong concern for environmental issues and promotes sustainable logistics and circular practices to address critical issues such as waste generation, resource scarcity, renewable resource use, and climate change. The study examines the relationships between green logistics practices, I4.0 technologies, and CE adoption while also considering the moderating effects of institutional pressure and supply chain flexibility. The findings suggest that firms can enhance CE adoption driven by I4.0 technologies with green logistics practices as a mediator, and the moderating effect of supply chain flexibility is significant while the moderating effect of institutional pressure is insignificant. The study provides valuable insights for managers and contributes to the theoretical understanding of green logistics and CE adoption.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Management
Sudhanshu Joshi, Manu Sharma, Akhilesh Barve
Summary: This study employs the Best Worst Method (BWM) to identify the most critical implementation barriers of IoT and Blockchain technology in Waste Electrical and Electronic Equipment (WEEE) management. The findings reveal that developing a legislative support system, ineffective database management, low understanding of cognitive technologies, and concerns regarding information security and privacy are the key issues in implementing these technologies in closed-loop supply chains.
SUPPLY CHAIN FORUM
(2023)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sudhanshu Joshi, Mukesh Prasad, Shalini Bartwal
Summary: This study proposes a model to examine the critical barriers and suggest strategies for implementing Circular Economy (CE) in the Oil & gas (O&G) industry. The results show that 'knowledge barriers' are the most critical, and the strategies 'Developing collaborative model' and 'Internal research and development, innovation' are the most significant for reducing the barriers.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Banu Y. Ekren, Yigit Kazancoglu, Sunil Luthra, Mukesh Prasad
Summary: Food waste reduction and security are major concerns in agri-food supply chains, as more than a third of global food production is wasted or lost due to mismanagement. Resilient food supply chains need to address challenges such as resource scarcity, climate change, and waste generation. This study explores supply chain innovations, using SWARA analysis, to identify the most significant innovations for developing resilient food supply chains. The results highlight the importance of business strategy and technological innovations in bringing resilience to food supply chains.
Article
Business
Manu Sharma, Deepak Kaushal, Sudhanshu Joshi
Summary: Social media has become a major source of information for young users, but it has a severe impact on mental state due to information overload, which is still a concern for researchers. The addiction of Generation Z users to mobile phones/gadgets is increasing with the rise of social media, leading to a complete transformation in their behavioral outcomes. Behavioral issues such as stress, fatigue, fear of missing out, phubbing, and anxiety are on the rise, but the relationship between these issues and information overload has not been sufficiently examined. The study finds that social media platforms need to understand users' compulsive usage, which results in fatigue and anxiety, and government information support plays a positive role in reducing fatigue and anxiety.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Review
Multidisciplinary Sciences
Sunil Luthra, Shruti Agrawal, Anil Kumar, Manu Sharma, Sudhanshu Joshi, Jatin Kumar
Summary: Psychological and mental well-being of young adults has been greatly influenced by the COVID-19 pandemic, leading to a global concern. This research study provides an overview of the international scientific studies on the effect of COVID-19 on young adults' psychological well-being. It reveals the top-cited authors, documents, journals, productive countries, keywords, and themes in this area. The United States has contributed the most publications, followed by the United Kingdom and Italy. The study highlights the importance of addressing the psychological health of young adults worldwide.
Article
Health Policy & Services
Sudhanshu Joshi, Manu Sharma
Summary: The widespread use of Blockchain technology (BT) in developing nations is still in its early stages and requires a comprehensive evaluation. The healthcare sector is increasingly in need of digitalization to improve operational efficiency. However, the limited research on BT has hindered its full utilization in the healthcare sector. This study aims to identify the main obstacles to BT adoption in developing nations' public health systems, using a multi-level analysis and hybrid approach. The findings of this study provide guidance and insight for decision-makers on implementation challenges.
Article
Management
Manu Sharma, Sudhanshu Joshi
Summary: This study aims to explore the factors that affect the selection of digital suppliers and evaluate the alternatives for identifying the best supplier that enhances the quality management systems (QMS) for digital supply chains (DSCs). The study reveals that supplier competency is the most significant factor in selecting digital suppliers, and supplier S-8 has been ranked as the best supplier.
Article
Business
Sudhanshu Joshi, Rohit Kumar Singh, Manu Sharma
Summary: This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues. The findings can provide guidance for agribusiness regulators and intermediaries, while contributing to a new understanding of sustainable agribusiness-based issues in India.
GLOBAL BUSINESS REVIEW
(2023)
Article
Business
Rohit Kumar Singh, Sudhanshu Joshi, Manu Sharna
GLOBAL BUSINESS REVIEW
(2023)