Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 13, Issue 6, Pages 1195-1198Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op900243c
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Funding
- Samenwerkingsverband Noord-Nederland (Cooperation Northern Netherlands)
- EFRO
- European Commission [NMP4-SL-2008-214340]
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The recently discovered technique of deracemization by means of attrition-induced grinding of a solid conglomerate in contact with a solution wherein racemization occurs has been used with a derivative of 2-chlorophenyl glycine, the key chiral component in the synthesis of Clopidogrel (Plavix). Deracemization of the racemate proceeds to a single enantiomer and in essentially absolute enantiomeric excess. Further conversion of enantiomerically pure material to Clopidogrel was achieved in 88% yield.
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