Journal
ORGANIC LETTERS
Volume 20, Issue 18, Pages 5622-5625Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02323
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Funding
- Rutgers University
- NSF [CAREER CHE-1650766]
- China Scholarship Council [201606350069]
- NSF-MRI [CHE-1229030]
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A general, transition-metal-free, and operationally simple method for esterification of amides by a highly selective cleavage of N-C(O) bonds under exceedingly mild conditions is reported. The reaction is characterized by broad substrate scope and excellent functional group tolerance. The potential of this mild esterification is highlighted by late-stage diversification of natural products and pharmaceuticals. Conceptually, the metal-free acyl functionalization of amides represents a significant step forward as a practical alternative to ligand exchange in acylmetal intermediates.
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