Journal
ORGANIC LETTERS
Volume 20, Issue 17, Pages 5167-5171Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02112
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Funding
- SERB, India [YSS/2014/000383, PDF/2016/000242]
- CSIR
- UGC
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A straightforward Pd(II)-catalyzed general strategy was developed for the CS-selective arylation of the 2-pyridone core with easily available aryl iodides. The transformation was highly regioselective and accomplished with a wide scope and functional group tolerance. Silver nitrate played a crucial role in this direct site-selective arylation. The method was extended to synthesize biologically active molecules.
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