F- Nucleophilic-Addition-Induced [3+2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same step, which delicately joins together these two different metallic intermediates. molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.