Journal
ORGANIC LETTERS
Volume 16, Issue 16, Pages 4098-4101Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501789c
Keywords
-
Categories
Funding
- National Institutes of Health [NIH GM-082935]
- National Science Foundation [NSF-0847108]
Ask authors/readers for more resources
A highly efficient method for the enantioselective one-pot synthesis of 1,3-oxazolidines and 1,3-oxazinanes has been reported. The reaction proceeds via the formation of hemiaminal intermediates obtained by the enantioselective addition of respective alcohols to imines catalyzed by a chiral magnesium phosphate catalyst, followed by intramolecular cyclization under mildly basic conditions. A wide range of substrates have been converted to the respective chiral heterocyclic products in high yields and with excellent enantioselectivities using this one-pot procedure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available