Journal
ORGANIC LETTERS
Volume 17, Issue 1, Pages 50-53Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol503213z
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Funding
- JSPS [25888007]
- JGC-S scholarship foundation
- Nagoya University
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Grants-in-Aid for Scientific Research [26288023, 25888007, 26810056] Funding Source: KAKEN
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The selective synthesis of multiarylated acetonitriles via sequential palladium-catalyzed arylations of chloroacetonitrile is reported. The three aryl groups are installed via a Pd-catalyzed Suzuki-Miyaura cross coupling reaction followed by back-to-back C-H arylations to afford triarylacetonitriles in three steps with no over-arylation at any step. The triarylacetonitrile products can be converted into highly functionalized species including tetraarylmethanes. This new strategy provides rapid access to a variety of unsymmetrical tri- and tetraarylmethane derivatives from simple, readily available starting materials.
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