Journal
ORGANIC LETTERS
Volume 16, Issue 9, Pages 2386-2389Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol500711z
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Funding
- Japan Society for the Promotion of Science (JSPS) [24750036]
- Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [24750036] Funding Source: KAKEN
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4-Chloroindoles were synthesized from readily available 2,3-dichloroaniline derivatives and terminal alkynes. The catalyst composed of palladium and dicyclohexyl(dihydroxyterphenyl)phosphine (Cy-DHTP) enabled ortho-selective Sonogashira coupling, and subsequent cyclization afforded 4-chloroindoles in high yields. This transformation was successfully applied to the one-pot synthesis of 2,4-disubstituted indoles via Suzuki-Miyaura coupling after indole formation.
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