Journal
ORGANIC LETTERS
Volume 16, Issue 8, Pages 2256-2259Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol500764q
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Funding
- Swedish Research Council (Vetenskapsradet)
- Wenner-Gren Foundation
- Knut and Alice Wallenberg Foundation
- Berzelii Center EXSELENT
- Department of Organic Chemistry at Stockholm University
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A ruthenium complex formed from commercially available [Ru(p-cymene)Cl-2](2) and 1,4-bis(diphenylphosphino)butane catalyzes the racemization of aromatic alpha-hydroxy ketones very efficiently at room temperature. The racemization is fully compatible with a kinetic resolution catalyzed by a lipase from Pseudomonas stutzeri. This is the first example of dynamic kinetic resolution of alpha-hydroxy ketones at ambient temperature in which the metal and enzyme catalysts work in concert in one pot at room temperature to give quantitative yields of esters of alpha-hydroxy ketones with very high enantioselectivity.
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