Journal
ORGANIC LETTERS
Volume 16, Issue 5, Pages 1410-1413Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol500197x
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Funding
- Science & Technology Project of Guangdong Province [2011A080403020]
- Fundamental Research Funds for the Central Universities [2012N06]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing, China [2012ZX09301002-001-005]
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Periconianone A (1), a polyoxygenated sesquiterpenoid with a new 6/6/6 tricarbocyclic skeleton, and periconianone B (2) were isolated from the endophytic fungus Periconia sp. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu K alpha). The biosynthesis of the unusual six-membered carbonic ring of 1 was postulated to be formed through intramolecular aldol condensation. Compounds 1 and 2 showed significant neural anti-inflammatory activity.
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