Article
Biochemistry & Molecular Biology
Fu-Ying Qin, Dai-Wei Wang, Te Xu, Bi-Shan Zhang, Yong -Xian Cheng
Summary: Novel compounds isolated from Ganoderma cochlear showed potential in improving glucose uptake and reducing collagen expression, indicating possible therapeutic effects on insulin resistance and fibrosis-related conditions.
Article
Biochemistry & Molecular Biology
Xiao-Hui Meng, Fu-Ying Qin, Xiao-Ting Jiang, Yu Li, Yong-Xian Cheng
Summary: Five pairs of meroterpenoid enantiomers were isolated from the fruiting bodies of Ganoderma cochlear, with their structures elucidated through NMR and HRESIMS data. Two of these enantiomers were found to inhibit renal fibrosis in TGF-beta 1-induced rat kidney proximal tubular cells through biological evaluation.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Da-Shuang Fang, Chun-Ru Cheng, Ming-Hua Qiu, Xing-Rong Peng
Summary: Three new meroterpenoids, cochlearins J-L (1-3), and three known meroterpenoids (4-6) were isolated from Ganoderma cochlear fruiting bodies. NMR and HRESIMS were used to determine the structures of the new compounds, and the stereostructures of 1-3 were confirmed by calculated ECD and optical rotation methods. In addition, the alpha-glucosidase inhibitory activity of compounds (+)-1, (-)-1, (+)-2, (-)-2, (+)-3, (-)-3, and 4-6 was evaluated, and (+)-1, (-)-1, and (+)-2 exhibited stronger inhibition against alpha-glucosidase compared to the positive control ursolic acid.
Article
Chemistry, Multidisciplinary
Fu-Ying Qin, Te Xu, Yan-Peng Li, Hao-Xing Zhang, Dan Cai, Li-Zhong Liu, Yong-Xian Cheng
Summary: Researchers isolated and studied multiple new compounds from Ganoderma cochlear, determining their activities against renal fibrosis, breast cancer, and insulin resistance. The compounds showed potential pharmacological value in regulating cell expression and protein levels.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Organic
Stephen A. Chamness, Emily F. Traficante, Trenton R. Vogel, Corinna S. Schindler
Summary: This article provides a review of the synthetic research on meroterpenoids cochlearol A and B, summarizing the strategies developed since their isolation.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Organic
Michal Simek, Katerina Bartova, Samy Issad, Miroslav Hajek, Ivana Cisarova, Ullrich Jahn
Summary: A unified approach to synthesizing meroterpenoids produced by Ganoderma applanatum is presented. The key synthetic sequence involves anionic ketone allylation/oxy-Cope rearrangement/alpha-oxygenation and a cyclization reaction based on persistent radical effect. The relative configuration of one of the compounds, applanatumol V, needs to be revised. Some of the compounds exhibit significant cytotoxic and antioxidant properties.
Article
Chemistry, Medicinal
Madhu Babu Sura, Yun-Li Peng, Dan Cai, Yong-Xian Cheng
Summary: Four novel epimeric meroterpenoids and two lactonized meroterpenoids were isolated from the fruiting bodies of Ganoderma cochlear. These compounds demonstrate significant anti-inflammatory activity.
Review
Biochemistry & Molecular Biology
Xing-Rong Peng, Sybille B. Unsicker, Jonathan Gershenzon, Ming-Hua Qiu
Summary: This review discusses the structures and biosynthesis of Ganoderma meroterpenoids (GMs) newly discovered from 2018 to 2022, as well as the chemical synthesis and biological activity of some interesting GMs. A plausible biosynthetic pathway for GMs is proposed for the first time, which will stimulate further research on the biosynthetic pathway in Ganoderma species and the chemical synthesis of GMs as important bioactive compounds for drug development.
NATURAL PRODUCT REPORTS
(2023)
Article
Chemistry, Applied
Jiao-Jiao Zhang, Yun Dong, Fu-Ying Qin, Yong-Ming Yan, Yong-Xian Cheng
Summary: In this study, two new mertoterpenoids and a new alkaloid were isolated from the fruiting bodies of Ganoderma australe, along with five known compounds. Biological assessments showed that some of these compounds could protect SH-SY5Y cells from glutamate-induced neural excitotoxicity.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dan Cai, Jiao-Jiao Zhang, Ze-Hong Wu, Fu-Ying Qin, Yong-Ming Yan, Mei Zhang, Yong-Xian Cheng
Summary: Seven new meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum, along with one known meroterpenoid. Several of the isolated compounds showed significant inhibition on human cancer cell migration, with (+)-6 and (+)-8 possibly related to the downregulation of N-cadherin.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yan-Peng Li, Xiao-Ting Jiang, Fu-Ying Qin, Hao-Xing Zhang, Yong-Xian Cheng
Summary: Five new meroterpenoids were isolated from the fruiting bodies of G. cochlear, showing significant inhibition of COX-2 enzyme. Among them, two compounds were found to suppress the metastatic phenotype of TNBC cells by impeding the epithelial-mesenchymal transition (EMT).
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jiao-Cen Guo, Li Yang, Qing-Yun Ma, Ya-Zhe Ge, Fan-Dong Kong, Li-Man Zhou, Fei Zhang, Qing-Yi Xie, Zhi-Fang Yu, Hao-Fu Dai, You-Xing Zhao
Summary: This study isolated ten new compounds from the fruiting bodies of Ganoderma australe, including seven undescribed lostane-type triterpenoids and one polyhydroxylated sterol. These new compounds showed significant a-glucosidase inhibitory activities and one exhibited weak cytotoxicity against cancer cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Jiao-Jiao Zhang, Ping-Xia Guo, Zhong-Hui Yang, Dan Cai, Wei-Feng Dai, Qing Lu, Yong-Xian Cheng
Summary: Six new meroterpenoids were isolated from Ganoderma petchii, and their structures and relative configurations were determined using spectroscopic methods and 13C NMR calculations. Enantiomers of the new racemics were obtained through chiral separation. The absolute configurations of these new compounds were confirmed using computational methods, CD comparisons, and X-ray diffraction analysis. Biological studies showed that (+)-6 and (-)-6 significantly inhibited the migration of the MDA-MB-231 cell line, which is associated with triple negative breast cancer.
Article
Chemistry, Organic
Daan V. Bunt, Sahar El Aidy, Adriaan J. Minnaard
Summary: The meroterpenoids fornicin A, fornicin D, and ganodercin D found in mushrooms of the Ganoderma genus were synthesized through a concise and divergent route. The unsaturated gamma-ketoacid moiety was obtained via an optimized step-wise aldol condensation. Additionally, a protocol for THP-protection of a phenolic hydroxyl group under basic conditions was developed, adding to the versatility of this protecting group.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yan-Jiao Yin, Hong Zhou, Jiao-Jiao Zhang, Dan Cai, Yuan-Nan Yuan, Zhong-Hui Yang, Yong-Xian Cheng
Summary: Thirteen new compounds, including four pairs of enantiomers and one known compound, were isolated from the fruiting bodies of Ganoderma sinensis. The structures of these compounds were determined through spectroscopic, computational methods, and CD comparisons. One of the compounds, (-)-zizhine Z1, exhibited inhibition of cell migration in the MDA-MB-231 cell lines. This study provides insights into the chemical profile of G. sinensis and lays the groundwork for its development as functional products for chronic disorders.
CHEMISTRY & BIODIVERSITY
(2023)
