Journal
ORGANIC LETTERS
Volume 16, Issue 4, Pages 1252-1255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5002522
Keywords
-
Categories
Funding
- EPSRC
- RSC
Ask authors/readers for more resources
The synthesis of tertiary thiols in enantiomerically enriched form is accomplished by lithiation of enantiomerically enriched N-aryl allylic thiocarbamates. Formation of an allyllithium derivative promotes intramolecular N to C aryl migration to the position alpha to sulfur, generally with good stereospecificity. The substrates may themselves be obtained by Pd-catalyzed enantioselective [3,3]-sigmatropic rearrangement of N-aryl O-allyl thiocarbamates. Solvolysis of the product thiocarbamates yields tertiary thiols, which may be converted to sulfide derivatives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available