4.8 Article

Three-Component Povarov Reaction-Heteroannulation with Arynes: Synthesis of 5,6-Dihydroindolo[1,2-a]quinolines

Journal

ORGANIC LETTERS
Volume 16, Issue 6, Pages 1756-1759

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol500447r

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Funding

  1. EPFL (Switzerland)
  2. Swiss National Science Foundation (SNSF)

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A reaction of 2-acyl substituted tetrahydroquinolines, prepared by Lewis acid-catalyzed three-component reaction of alpha-oxo aldehydes, anilines, and dienophiles, with in situ generated arynes afforded 5,6-dihydroindolo[1,2-a]-quinolines in good to excellent yields.

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