Journal
ORGANIC LETTERS
Volume 16, Issue 11, Pages 2982-2985Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5011196
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Funding
- Conseil Regional Nord-Pas de Calais (program PRIM)
- Comite Nord de la Ligue contre le Cancer
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The first enantioselective synthesis of 4-azapodophyllotwdn derivatives by partial transfer hydrogenation of lactone-fused quinolines was achieved using a chiral Bronsted acid catalyst. This reaction was extended to a large scope of substrates with good yields and enantioselectivities.
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