Journal
ORGANIC LETTERS
Volume 15, Issue 9, Pages 2128-2131Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4006008
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Funding
- University of Toronto
- OGS
- University of Genova
- NSERC
- Natural Sciences and Engineering Research Council (NSERC)
- Merck for an Industrial Research Chair
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A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.
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