4.8 Article

Kinetic Resolution of N-Acyl-Thiolactams via Catalytic Enantioselective Deacylation

Journal

ORGANIC LETTERS
Volume 15, Issue 11, Pages 2790-2793

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol401122g

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Funding

  1. National Science Foundation [CHE-1012979]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [1012979] Funding Source: National Science Foundation

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Methanolysis of N-acyl-thiazolidin-2-thiones and -oxazolidin-2-thiones in the presence of acyl transfer catalyst benzotetramisole (BTM) proceeds in a highly enantioselective fashion thus enabling kinetic resolution of these substrates.

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