Article
Chemistry, Multidisciplinary
Maxime Boddaert, Pauline Bianchi, Diana V. Silva-Brenes, Ancuta Musina, Marc Winter, Philippe M. C. Roth, Pierre-Yves Renard, Julien Legros, Jean-Christophe M. Monbaliu
Summary: This study introduces a new, efficient, safe, and sustainable flow protocol using ozone to oxidatively neutralize sulfur-based chemical warfare agent simulants. The combination of computational research and experimental validation has successfully achieved rapid neutralization under flow conditions.
Article
Chemistry, Multidisciplinary
Victor-Emmanuel H. Kassin, Romain Morodo, Thomas Toupy, Isaline Jacquemin, Kristof Van Hecke, Raphael Robiette, Jean-Christophe M. Monbaliu
Summary: A scalable continuous flow process has been developed for the efficient and safe electrophilic alpha-aminohydroxylation of enolizable ketones using alpha-chloronitroso derivatives. The process showcases the economic and efficient nature of alpha-chloronitroso derivatives in transferring electrophilic synthons of hydroxylamine, allowing for the preparation of valuable molecules with high atom economy. The process features sequential modules, in-line extractions, and in-line analytical procedures to improve process control and safety, making it easily transposable to pilot scale and ideal for compound library screening in medicinal chemistry.
Article
Robotics
Jesse Haviland, Peter Corke
Summary: NEO is a fast and purely reactive motion controller for manipulators that can avoid obstacles and maximize manipulability. It is best suited as a reactive local controller in more complex scenes, along with a global motion planner.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Engineering, Aerospace
Hyun-Gi Kim, Sung Chan Kim
Summary: The study analyzed the dynamic characteristics of aircraft external stores by constructing equivalent models, ensuring accurate simulation of the dynamic properties of the components. It was confirmed that the newly developed equivalent model assembly could be used for aircraft dynamics characteristics analysis through comparison with the modes of the full-scale model.
AEROSPACE SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongli Zhang, Mengqing Xu, Haihua Luo, Shuangquan Wu, Xiaofang Gao, Qiong Wu, Huan Xu, Yi Liu
Summary: To combat bacteria and biofilm infections, this study developed bioactive chitin/Mn3O4 composite hydrogels with outstanding photothermal antibacterial and antibiofilm activities. These hydrogels showed favorable biocompatibility and antioxidant properties, and demonstrated excellent wound healing performance in a mouse model with S. aureus biofilm-infected wounds. This research broadens the scope for chitin hydrogels with antibacterial properties and offers a promising alternative for bacterial-associated wound infection therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Xinwei He, Ruxue Li, Pui Ying Choy, Mengqing Xie, Jiahui Duan, Qiang Tang, Yongjia Shang, Fuk Yee Kwong
Summary: The study presents a method for accessing dibenzofurans with diverse substitution patterns through a double 1,4-conjugate addition/intramolecular annulation cascade reaction, which allows for efficient manipulation of substituents on the core structure.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Chemistry, Organic
Yanan Liu, Pui Ying Choy, Demao Wang, Mengdi Wu, Qiang Tang, Xinwei He, Yongjia Shang, Fuk Yee Kwong
Summary: A 1,8-diazabicyclo[5.4.0]-undec-7-ene-promoted cascade double-annulation of ortho-alkynyl quinone methide is developed for constructing of 2-aryl-4-hydroxybenzo-[c]-chromen-6-ones. This method offers operational simplicity and good functional group compatibility.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Massimo Manzini, Erik Demeulemeester, Marcello Urgo
Summary: The paper discusses the technological evolution and customization needs in the automotive industry, and proposes a scheduling method for multi-product assembly lines to minimize batch completion time.
ROBOTICS AND COMPUTER-INTEGRATED MANUFACTURING
(2022)
Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Goutam Chakraborty, Rajani Kant Chittela, Padma Nilaya Jonnalgadda, Haridas Pal
Summary: Detection and quantification of bioanalytes using NIR probes have advantages of negligible light scattering, minimal interference from background matrices, and deep sample penetration. This study presents a supramolecular dye-polymer complex as a promising NIR emitting turn-on probe for protamine sensing. The complex shows fluorescence enhancement due to binding onto the polymer surface, and further enhancement in the presence of protamine. This selective turn-on response is attributed to a structural change in the polymer upon interaction with protamine.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemical Research Methods
Jingjing Wang, Werner Pieter Veldsman, Xiaodong Fang, Yufen Huang, Xuefeng Xie, Aiping Lyu, Lu Zhang
Summary: Genome assembly is a computational technique used to create a comprehensive and precise representation of the entire genome by piecing together DNA fragments generated by sequencing technologies. Generating a high-quality human reference genome is crucial for understanding human biology and downstream genomic variation analysis. This paper benchmarks various strategies for human genome assembly using different sequencing technologies and tools, and compares their performances in terms of continuity, accuracy, completeness, variant calling, and phasing. It recommends the use of PacBio HiFi long-reads for low base errors, Oxford Nanopore long-reads for continuous contigs (with further polishing for quality improvement), and Hi-C for chromosome-level scaffolding. Combining multiple technologies can further enhance the quality and completeness of genome assembly, and for diploid assembly, hifiasm is recommended as the best tool for human diploid genome assembly using PacBio HiFi and Hi-C data. Advances in human diploid assemblers using PacBio HiFi reads and other technologies are expected to enable high-quality, chromosome-level, and haplotype-resolved human genome assemblies in the future.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Chemistry, Analytical
Boyu Zhang, Hangjin Zou, Yanfei Qi, Xinming Zhang, Rongtian Sheng, Yang Zhang, Ruimeng Sun, Lixia Chen, Ruijuan Lv
Summary: A new P2W18Fe4/PDA nanocomposite with peroxidase activity has been synthesized for the detection of GSH and E. coli O157:H7. The functionalization of PDA enhances the catalytic activity of P2W18Fe4, enabling highly sensitive detection of GSH and E. coli O157:H7.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Su Zhou, Yinwu Li, Xiangrong Liu, Wenhao Hu, Zhuofeng Ke, Xinfang Xu
Summary: An asymmetric three-component reaction method has been reported to synthesize alpha-alkoxy-beta-amino-ketones with high yields and excellent enantioselectivity. This atom-economic reaction involves catalytic alkyne oxidation, ylide formation, and Mannich-type addition sequence.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Bing Bai, Shaolong Qi, Kai Yang, Xinyang Yu, Ruijun Jian, Tianfang Zhang, Daming Wang, Hongbo Meng, Yifan Zhao, Yu Xia, Huaping Xu, Guocan Yu, Zuobing Chen
Summary: In this study, self-assembled Se-CQDs-lecithin nanoparticles (Se-LEC NPs) were developed to effectively scavenge ROS and accumulate in the liver, exerting beneficial therapeutic efficacy on HIRI. This work may open a new avenue for the design of self-assembled Se-CQDs NPs for the treatment of HIRI and other ROS-related diseases.
Article
Chemistry, Multidisciplinary
Chengkai Li, Wuchao Zhao, Jianghua He, Yuetao Zhang, Wangqing Zhang
Summary: Lewis pair polymerization with strong nucleophilic N-heterocyclic olefin and bulky organoaluminum successfully polymerizes and self-assembles two compounds into nano-assemblies. This method enables the rapid synthesis of nanoparticles with different morphologies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Shohei Eda, Fumiaki Eguchi, Hiroshi Haneda, Toshiyuki Hamura
CHEMICAL COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Shohei Eda, Toshiyuki Hamura
Article
Chemistry, Physical
Shohei Eda, Igor Nasibullin, Kenward Vong, Norio Kudo, Minoru Yoshida, Almira Kurbangalieva, Katsunori Tanaka
Article
Multidisciplinary Sciences
Kenward Vong, Shohei Eda, Yasuhiro Kadota, Igor Nasibullin, Takanori Wakatake, Satoshi Yokoshima, Ken Shirasu, Katsunori Tanaka
NATURE COMMUNICATIONS
(2019)
Article
Materials Science, Multidisciplinary
Ryonosuke Sato, Shohei Eda, Haruki Sugiyama, Hidehiro Uekusa, Toshiyuki Hamura, Takehiko Mori
JOURNAL OF MATERIALS CHEMISTRY C
(2019)
