Journal
ORGANIC LETTERS
Volume 15, Issue 7, Pages 1666-1669Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol400444g
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Funding
- Welch Foundation [E-1744]
- ACS Organic Division (SURF fellowship)
- University of Houston
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N-Substituted indoles are synthesized from primary amines through a tandem reaction sequence. Initial condensation of the amine with an alpha-(o-haloaryl)ketone or aldehyde is followed by intramolecular aryl amination catalyzed by CuI. A variety of anilines and alkyl amines, including those with significant steric demands, are converted to indoles in high yields and with varying indole substitution.
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