Article
Chemistry, Multidisciplinary
Saikat Pahan, Sanjit Dey, Gijo George, Souvik Panda Mahapatra, DRGKoppalu R. Puneeth Kumar, Hosahudya. N. Gopi
Summary: In this study, chiral beta-double helices constructed from specific amino acids were observed in both single crystals and in solution. These structures can transport ions across membranes, suggesting their potential applications in designing functional foldamers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Peng Teng, Mengmeng Zheng, Darrell Cole Cerrato, Yan Shi, Mi Zhou, Songyi Xue, Wei Jiang, Lukasz Wojtas, Li-June Ming, Yong Hu, Jianfeng Cai
Summary: This study demonstrated the solid-state right-handed helical propensity of the 4(13)-helix of L-alpha/L-sulfono-gamma-AA peptides, even as short as 11-mer, using high-resolution X-ray single crystallography. The atomic level folding conformation of the foldamers was elucidated by 2D NMR and circular dichroism, showing that the helical handedness of this class of foldamer is controlled by the chirality of their chiral side chains.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Microbiology
Agustina Fernandez, Maria Laura Colombo, Lucrecia M. Curto, Gabriela E. Gomez, Jose M. Delfino, Fanny Guzman, Laura Bakas, Ismael Malbran, Sandra E. Vairo-Cavalli
Summary: Fusarium graminearum is the causative agent of Fusarium head blight (FHB), a disease that leads to significant reduction in wheat yield and poses health risks due to mycotoxins in infected grains. Plant defensins are small basic peptides with conserved structures that play a role in host defense, and novel antifungal peptides designed from DefSm2 exhibit promising activity against F. graminearum, suggesting potential for development as fungicidal agents.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Qian Li, Longteng Zhang, Nils Arneborg, Rene Lametsch
Summary: This study illustrates the influence of growth medium and the crucial choice of yeast species for obtaining target gamma-glutamyl peptides for kokumi sensation.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Markus R. P. Pielmeier, Tom Nilges
Summary: Phosphorene and SnIP are two-dimensional and one-dimensional semiconductors formed from black phosphorus and SnI2, synthesized through mineralization and short way transport with similar yet different preparation methods. Investigating the formation mechanisms of these two compounds is of crucial importance for energy conversion, storage, and catalysis applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Valentin Leannec-Rialland, Alejandro Cabezas-Cruz, Vessela Atanasova, Sylvain Chereau, Nadia Ponts, Miray Tonk, Andreas Vilcinskas, Nathalie Ferrer, James J. Valdes, Florence Richard-Forget
Summary: In this study, it was found that treatment with the reduced form of the tick defensin DefMT3's gamma-core, referred to as TickCore3 (TC3), can decrease Fusarium graminearum growth and suppress mycotoxin production. Molecular dynamics revealed that TC3 is recruited by specific membrane phospholipids in F. graminearum, and the oxidized form of TC3 loses activity. Capping the cysteine residues of TC3 with methyl groups reduces its inhibitory efficacy.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Software Engineering
Hiroshi Kagawa, Yasuaki Ito, Koji Nakano, Ryota Yasudo, Yuya Kawamata, Ryota Katsuki, Yusuke Tabata, Takashi Yazane, Kenichiro Hamano
Summary: This article proposes a high-throughput FPGA implementation for solving the QUBO problem. The implementation uses different bit-selection strategies and simulated annealing for local search. The results show that the proposed circuit is efficient and can search a large number of solutions in a short amount of time.
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE
(2023)
Article
Chemistry, Physical
Vladimir Kubyshkin, Jochen Burck, Oleg Babii, Nediljko Budisa, Anne S. Ulrich
Summary: Circular dichroism is a conventional method for studying the secondary structures of peptides and proteins. The polyproline-II helix, while not exhibiting strictly conserved spectroscopic appearance, is significantly influenced by the surrounding solvent environment. Changes in solvation can lead to shifts and variations in the circular dichroism spectra, with new features potentially emerging in nonpolar environments. Additionally, the transition to a transmembrane state in isotropic liposomes is correlated with specific spectral changes, indicating the importance of considering the solvent environment in assessing circular dichroism spectra.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Xingyue Li, Andrew L. Sabol, Patrick J. Salveson, James S. Nowick
Summary: Researchers have developed a new beta-turn template, (delta)MeOrn, which can induce a beta-hairpin conformation in peptides. This template demonstrates superior folding compared to (delta)Orn and is comparable to d-Pro-Gly.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Phasit Charoenkwan, Sakawrat Kanthawong, Nalini Schaduangrat, Pietro Li', Mohammad Ali Moni, Watshara Shoombuatong
Summary: This study presents a computational approach (SCMRSA) for identifying and characterizing anti-MRSA peptides without the use of 3D structural information. SCMRSA accurately identifies anti-MRSA peptides and provides a more in-depth explanation. A user-friendly web server has also been established for easy access.
Article
Materials Science, Biomaterials
Qingjing Niu, Shuhui Gao, Xingwen Liu, Jinghui Chong, Lixia Ren, Kongying Zhu, Wenxiong Shi, Xiaoyan Yuan
Summary: In this study, aromatic monoamines were grafted onto gamma-poly(glutamic acid) to enhance intracellular trehalose uptake in human red blood cells. The amphiphilic gamma-PGA nanoparticles showed increased membrane permeability of trehalose, resulting in improved cryosurvival of hRBCs. Molecular dynamics simulation confirmed the interaction of the polymers with the phospholipid bilayer, suggesting a potential approach for glycerol-free cryopreservation of human cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Phasit Charoenkwan, Nalini Schaduangrat, Pietro Lio, Mohammad Ali Moni, Pramote Chumnanpuen, Watshara Shoombuatong
Summary: This study presents a machine learning-based method for rapid identification of peptides with antimalarial activity using only sequence information. The proposed method achieves high accuracy and correlation in predicting the antimalarial ability of peptides, and provides insights into the functional mechanisms of antimalarial peptides. Additionally, a user-friendly online computational platform is made available for high-throughput identification of potential antimalarial peptide candidates.
Article
Hematology
Fraser L. Macrae, Frauke Swieringa, Johan W. M. Heemskerk, Robert A. S. Ariens
Summary: This study found that increasing the percentage of fibrinogen gamma' in static conditions leads to higher clot density, thinner fibers, and slower lysis. Under flow conditions, high gamma' (30%) results in faster and increased fibrin deposition, with larger clot volume and height.
Article
Chemistry, Multidisciplinary
John A. Clark, Damian Kusy, Olena Vakuliuk, Maciej Krzeszewski, Krzysztof J. Kochanowski, Beata Koszarna, Omar O'Mari, Denis Jacquemin, Daniel T. Gryko, Valentine I. Vullev
Summary: This study investigates the effects of electronic coupling through biaryl linkers on the excited-state symmetry breaking of hybrid dyes. It is found that strengthening the donor-acceptor electronic coupling decreases the charge transfer rates and the propensity for symmetry breaking. In cases of intermediate electronic coupling, the dyes exhibit white fluorescence.
Article
Chemistry, Multidisciplinary
Hanna Chen, Lin Zhong, Haibo Zhou, Tao Sun, Guannan Zhong, Qiang Tu, Yan Zhuang, Xianping Bai, Xingyan Wang, Jiaying Xu, Liqiu Xia, Yuemao Shen, Youming Zhang, Xiaoying Bian
Summary: Nonribosomal peptide synthetases (NRPSs) can incorporate nonproteinogenic amino acids into peptidyl backbones to increase structural diversity. This study identified a class of linear lipoheptapeptides featuring two unusual residues and revealed the β-hydroxylation mechanisms of Asp and His, which require the concerted action of specific enzymes and domains.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Ashwini Dolle, Veera Babu Nagati, Yamanappa Hunashal, Kiran Krishnamurthy, Anil Kumar Pasupulati, Srinivasarao Raghothama, Konkallu Hanumae Gowd
CHEMICAL BIOLOGY & DRUG DESIGN
(2019)
Article
Biochemistry & Molecular Biology
Jayasubba Reddy Yarava, Yusuke Nishiyama, Srinivasarao Raghothama, Krishna Venkatachala Ramanathan
CHEMICAL BIOLOGY & DRUG DESIGN
(2020)
Article
Materials Science, Multidisciplinary
M. Srinivas, Reddy Ch Venkata, Raghava Reddy Kakarla, Nagaraj P. Shetti, M. S. Reddy, V. Raghu Anjanapura
MATERIALS RESEARCH EXPRESS
(2019)
Article
Chemistry, Multidisciplinary
Rahi M. Reja, Vivek Kumar, Gijo George, Rajat Patel, D. R. G. Koppalu R. Puneeth Kumar, Srinivasarao Raghothama, Hosahudya N. Gopi
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Ashwini Dolle, K. Kasi Amarnath Reddy, Shubha Shridhar Gunaga, Kiran Krishnamurthy, Dillip Kumar Senapati, Abhijit Rana, Kishorkumar Sindogi, Himansu S. Biswal, Srinivasarao Raghothama, Konkallu Hanumae Gowd
JOURNAL OF PEPTIDE SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
K. Kasi Amarnath Reddy, Smriti Moi, Ashwini Dolle, Basavaprabhu Hosamani, Kiran Krishnamurthy, Sunita Prakash, Srinivasarao Raghothama, Konkallu Hanumae Gowd
HELVETICA CHIMICA ACTA
(2020)
Article
Chemistry, Multidisciplinary
PurraBuchi Reddy, M. B. Madhusudhana Reddy, Ramkrishna Reddy, Santosh Chhajed, Pramodkumar P. Gupta
STRUCTURAL CHEMISTRY
(2020)
Article
Infectious Diseases
Katharigatta N. Venugopala, Mohammed A. Khedr, Yarabahally R. Girish, Subhrajyoti Bhandary, Deepak Chopra, Mohamed A. Morsy, Bandar E. Aldhubiab, Pran Kishore Deb, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, V Rashmi, Mahmoud Kandeel, Sabah H. Akrawi, Madhusudana M. B. Reddy, Sheena Shashikanth, Osama Alwassil, Viresh Mohanlall
Review
Biochemistry & Molecular Biology
Soumen Mandal, Srinivas Mallapur, Madhusudana Reddy, Jitendra Kumar Singh, Dong-Eun Lee, Taejoon Park
Editorial Material
Chemistry, Multidisciplinary
Haribabu Arthanari, Kandala V. R. Chary, Thomas Szyperski, Krishna V. Ramanathan, Ramakrishna V. Hosur, Nagarajarao Suryaprakash, Srinivasarao Raghothama, Naranamangalam R. Jagannathan, Raymond S. Norton, Erode N. Prabhakaran, Paturu Kondaish, Sulakshana P. Mukherjee, Satish Kumar Adiga, RamaKrishna Vadrevu, Anirban Bhunia, David Joseph
MAGNETIC RESONANCE IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ashwini Dolle, Marimuthu Vijayasarathy, Shamasoddin Shekh, Yamanappa Hunashal, K. Kasi Amarnath Reddy, Sunita Prakash, Abhijit Rana, Himansu S. Biswal, Srinivasarao Raghothama, Konkallu Hanumae Gowd
Summary: The novel conopeptides Li504 and Li520, derived from the venom duct transcriptome of the marine cone snail Conus lividus, may act as oxidoreductases and have a certain impact on the oxidative folding of conotoxins.
Article
Engineering, Electrical & Electronic
J. Shashikanth, M. Shashank, H. N. Sumedha, Fahad A. Alharthi, Aatika Nizam, Madhusudhana Reddy, G. Nagaraju
Summary: This article discusses the environmental pollution caused by the textile industry and the use of bismuth oxychloride as a photocatalyst for degrading organic dyes. BiOCl was synthesized through a simple, low-cost method and extensively characterized. Its application in the synthesis of beta-enaminones was also studied, showing its potential for various catalytic reactions.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Chemistry, Physical
Smriti Moi, Basavaprabhu Hosamani, Kiran Kumar, Shubha Gunaga, Srinivasarao Raghothama, Konkallu Hanumae Gowd
Summary: This study focused on improving the photostability of avobenzone by adopting a skeletal modification approach and synthesizing new derivatives. The new avobenzone derivatives showed improved photostability, rapid recovery from degradation products, and enhanced response to the photostabilizer glutathione compared to the original avobenzone. Computational calculations using density functional theory supported the experimental observations, suggesting that these new derivatives could potentially serve as alternatives to avobenzone in sunscreen formulations.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Deepika Yadav, A. K. Dixit, S. Raghothama, Satish Kumar Awasthi
DALTON TRANSACTIONS
(2020)
Article
Chemistry, Multidisciplinary
Rajkumar Misra, Gijo George, Rahi M. Reja, Sanjit Dey, Srinivasarao Raghothama, Hosahudya N. Gopi
CHEMICAL COMMUNICATIONS
(2020)
