Article
Multidisciplinary Sciences
Ovgu Isbilen, Ender Volkan
Summary: Ethanolic extracts of Allium willeanum Holmboe showed significant cytotoxic and apoptotic activities on both MCF-7 and MDA-MB-231 breast cancer cell lines in vitro, with a more pronounced effect on highly metastatic breast cancer cells.
Article
Biochemistry & Molecular Biology
Keng-Shiang Huang, Yi-Ting Wang, Omkar Byadgi, Ting-Yu Huang, Mi-Hsueh Tai, Jei-Fu Shaw, Chih-Hui Yang
Summary: The study found that chlorophyllides composites can modulate the expression of various genes in breast cancer cells, including those associated with the endocrine and nervous systems. These findings provide valuable information for further research and development of novel cancer therapies.
Article
Biochemistry & Molecular Biology
Aykut Ozgur, Altan Kara, Nazan Goksen Tosun, Saban Tekin, Isa Gokce
Summary: Heat shock protein 90 (Hsp90) is a key chaperone overexpressed in cancer cells, making it a potential target for cancer therapy. Debio-0932, a second-generation inhibitor, showed promising anticancer activity by binding strongly to Hsp90 and inducing apoptosis in breast cancer cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bashir Mosayyebi, Leila Mohammadi, Ashkan Kalantary-Charvadeh, Mohammad Rahmati
Summary: The study demonstrated that amygdalin has cytotoxic effects on breast cancer cell lines, while being non-toxic to human skin fibroblast cell line. Amygdalin treatment resulted in decreased adhesion of cancer cells to fibronectin and collagen I, as well as reduced cell migration, particularly in MDA-MB-231 cells. Integrin alpha and beta levels were differentially regulated by amygdalin in both cancer cell lines, suggesting a role in cancer cell adhesion and migration.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Mar'iyah Najihah Abdullah, Shafida Abd Hamid, Salizawati Muhamad Salhimi, Nurul Awani Syazzira Jalil, Mohammad Al -Amin, Nor Saliyana Jumali
Summary: Breast cancer, the most common cancer among women, is facing a challenge in the development of new anticancer drugs due to increasing drug resistance. Benzimidazole derivatives with various functional groups have shown excellent anticancer activity. In this study, two series of N-sec and tert-butyl-2-phenylbenzimidazoles were designed and synthesized, and their inhibitory effects on MDA-MB-231 and MCF-7 cell lines were evaluated. Chloro-substituted benzimidazoles exhibited better inhibitory effects compared to nitro-substituted ones, and some derivatives showed selectivity towards specific cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Nutrition & Dietetics
Monika Kalinowska, Ewelina Golebiewska, Grzegorz Swiderski, Sylwia Meczynska-Wielgosz, Hanna Lewandowska, Anna Pietryczuk, Adam Cudowski, Aleksander Astel, Renata Swislocka, Mariola Samsonowicz, Anna Barbara Zlowodzka, Waldemar Priebe, Wlodzimierz Lewandowski
Summary: The study investigated seven derivatives of plant-derived hydroxybenzoic acid for their structural and biological properties, including antioxidant, lipophilicity, antimicrobial activity, and cytotoxicity. It discussed the relationship between the molecular structure and biological activity of hydroxybenzoic acids, providing valuable information for their potential application in dietary supplements, functional foods, or drugs.
Article
Biochemistry & Molecular Biology
Scott D. Hargrave, Anna M. Joubert, Barry V. L. Potter, Wolfgang Dohle, Sumari Marais, Anne E. Mercier
Summary: The non-steroidal THIQ-based microtubule disruptor STX3451, with enhanced pharmacokinetic and pharmacodynamic profiles, was explored for the first time in radiation biology. Pre-treatment with STX3451 increased cytotoxicity in breast cancer cells when combined with radiation, inducing more double-strand DNA breaks and potentially delaying DNA repair mechanisms through the repression of the DNA damage response element ATM. These findings may lead to the reduction of radiation and drug doses for optimal clinical efficacy.
Article
Biochemistry & Molecular Biology
Alan Ruben Estrada-Perez, Norbert Bakalara, Juan Benjamin Garcia-Vazquez, Martha Cecilia Rosales-Hernandez, Cynthia Fernandez-Pomares, Jose Correa-Basurto
Summary: Breast cancer is the most common malignant tumor in women, with a high death rate despite early diagnoses and treatment advances. Triple-negative breast cancer differs significantly from other types and requires new therapeutic approaches. Metabolic dysregulation is identified as a crucial difference between breast cancer stages and types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Paula Moyano, Jose Manuel Garcia, Jimena Garcia, Adela Pelayo, Pilar Munoz-Calero, Maria Teresa Frejo, Maria Jose Anadon, Maria Victoria Naval, Andrea Flores, Vega Alejandra Mirat, Javier Del Pino
Summary: The study found that chlorpyrifos may promote breast cancer cell proliferation through various mechanisms, including increasing reactive oxygen species, acetylcholine accumulation, and alterations in the Wnt/beta-catenin pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Cell Biology
Florian Keller, Roman Bruch, Franziska Clauder, Mathias Hafner, Ruediger Rudolf
Summary: The study found that extracellular matrix components play a significant role in regulating BSP expression, suggesting mechanisms for the formation of bone-associated metastasis in breast cancer that may involve local control of BSP levels through extracellular matrix degradation and release of growth factors.
Article
Biotechnology & Applied Microbiology
Sudhakar Chekuri, Satyanarayana Swamy Vyshnava, Swarupa Lakshmi Somisetti, Sai Bindu Karamthote Cheniya, Chakradhar Gandu, Roja Rani Anupalli
Summary: By extracting and identifying the active components of Acalypha indica leaves, quercetin was determined as the main chemical constituent. Our study shows the potential therapeutic advantages of quercetin for treating breast cancer, as it inhibits MCF-7 and MDA-MB-231 cells and promotes apoptosis. Due to its plant-based origin and fewer adverse effects, quercetin is a viable option for further clinical study.
Article
Oncology
Stefan Dimov, Anelia Ts Mavrova, Denitsa Yancheva, Biliana Nikolova, Iana Tsoneva
Summary: The study aimed to synthesize new thienopyrimidine derivatives and evaluate their cytotoxicity against breast cancer cell lines. The results showed high cytotoxicity of certain compounds against MDA-MB-231 and MCF-7 cells, highlighting the need for further investigation into the antitumor potential and mechanism of action of these compounds. Fluorescence studies indicated a rapid process of apoptosis in MDA-MB cells treated with a specific compound.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Homa Hajimehdipoor, Zahra Tahmasvand, Fatemeh Ghorban Nejad, Marc Maresca, Sadegh Rajabi
Summary: This study investigated the effects of rutin on the proliferation, metastasis, and angiogenesis of breast cancer cells. Rutin was found to stimulate the proliferation and migration of MDA-MB-231 and MCF-7 cells. It also modulated the expression of genes involved in cell adhesion and angiogenesis.
Article
Pharmacology & Pharmacy
Mohamed M. A. Hussein, Ahmed Abdelfattah-Hassan, Haitham Eldoumani, Walaa M. Essawi, Tariq G. Alsahli, Khalid Saad Alharbi, Sami I. Alzarea, Hassan Y. Al-Hejaili, Sara F. Gaafar
Summary: The anti-cancer effects of carnosine-loaded niosomes and melittin-loaded niosomes combined with olaparib in breast cancer cells were investigated. The results showed that these niosomes inhibited cancer cell viability and regulated the expression of various proteins and genes associated with cell proliferation. In addition, Mel-NIO demonstrated stronger anti-cancer effects compared to Car-NIO in breast cancer cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haseeb A. Khan, Amani A. Alghamdi, N. Rajendra Prasad, Salman H. Alrokayan, Basma S. Almansour, Ashraf A. K. Hatamilah
Summary: The water extract of Solanum nigrum (SNWE) exhibited cytotoxic effects on MCF-7 and MDA-MB-231 cells, potentially through the disruption of energy metabolism. Further studies using animal models of breast cancer are needed to explore its anticancer effects.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)