Article
Chemistry, Multidisciplinary
Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Gang Huang, Jianfeng Zeng, Mingyuan Gao
Summary: Radiolabeling plays a significant role in functionalizing inorganic nanoparticles, providing high-sensitive imaging capacities and accurate pharmacokinetic information. A novel LAGMERAL method utilizing a PEG ligand with DP terminal group allows for radiolabeling NPs through spare coordination sites. X-ray absorption spectroscopy studies investigated the coordination states of foreign metal ions on the particle surface. The stability of radioactively labeled Fe3O4 NPs prepared by colabeling with I-125 and Tc-99m was compared both in vitro and in vivo, highlighting the advantages of the LAGMERAL method for creating advanced NPs with various functionalities.
Article
Chemistry, Organic
Ming La, Dandan Liu, Xuerong Chen, Fang-Lin Zhang, Yirong Zhou
Summary: A novel palladium-catalyzed direct o-C-H iodination of benzaldehydes was successfully developed using a commercially available 2,5-bis(trifluoromethyl)aniline as the optimal Monodentate Transient Directing Group (MonoTDG), achieving moderate to excellent yields and good selectivity. Importantly, a concise two-step total synthesis of the natural product hernandial was demonstrated by merging this new MonoTDG-assisted C-H iodination with subsequent copper-catalyzed cross-coupling.
Article
Chemistry, Multidisciplinary
Lei Chen, Yun Gao, Jianxian Ge, Yi Zhou, Zhe Yang, Cang Li, Baoxing Huang, Kuan Lu, Dandan Kou, Dandan Zhou, Can Chen, Sixia Wang, Shuwang Wu, Jianfeng Zeng, Gang Huang, Mingyuan Gao
Summary: In this study, a clinically translatable kit for the convenient construction of MRI/NMI nanoprobes was developed by flow synthesis and anchoring group-mediated radiolabeling. The results showed that Tc-99m labeled nanoprobes can be obtained with a labeling yield of over 95% in 30 minutes by injecting Na[(TcO4)-Tc-99m] solution into the kit. The Fe3O4 nanoparticles sealed in the kit can be stored for 300 days without deteriorating the colloidal stability and radiolabeling yield, and the radiolabeled nanoprobes demonstrated promising clinical translational value by achieving high-resolution vascular images in mice.
Article
Nanoscience & Nanotechnology
Chaochao Fu, Linglong Meng, Jinfeng Wang, Qi Wang, Kun Yang, Wenming Zhang, Liping Li
Summary: The surface isocyanate functionalization on Li-rich oxides inhibits side reactions, improves cycle stability, and provides a potential method for designing better Li-rich cathode materials with enhanced electrochemistry performance.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Jennifer L. Troiano, Robert H. Crabtree, Gary W. Brudvig
Summary: Anchoring groups are important for attaching small molecules to metal oxide surfaces, such as in water-splitting dye-sensitized photoelectrochemical cells (WS-DSPECs). In this study, the surface loading of the silatrane anchoring group on titanium dioxide surfaces was optimized. The researchers found that previous methods resulted in low surface coverage, but they were able to uncover factors contributing to this issue and develop methods to greatly improve surface coverage, particularly through the use of a benzoic acid additive.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Chemistry, Applied
Zhiming Zhou, Chuanbiao Bie, Peize Li, Bien Tan, Yan Shen
Summary: This article presents a novel thioether-functionalized pyrene-based COF catalyst with ultrafine gold nanoparticles (Au NPs) as a cocatalyst, exhibiting remarkable photocatalytic activity and increased H2 generation rate under visible light.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Diego A. Flores-Cano, Noemi-Raquel Checca-Huaman, Isabel-Liz Castro-Merino, Camila N. Pinotti, Edson C. Passamani, Fred Jochen Litterst, Juan A. Ramos-Guivar
Summary: Novel magnetic nanohybrids composed of nanomaghemite covered by organic molecules were successfully synthesized at room temperature. The characterization results revealed the presence of different magnetic phases and controlled-size morphologies. Organic functionalization of the nanoparticles was demonstrated, and the nanohybrids showed potential applications in effluent remediation and biomedicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Szymczyk, Marcin Drozd, Agnieszka Kaminska, Magdalena Matczuk, Maciej Trzaskowski, Marta Mazurkiewicz-Pawlicka, Robert Ziolkowski, Elzbieta Malinowska
Summary: Nucleic acid extraction and purification are essential steps in sample preparation for multiple diagnostic procedures. This study comprehensively evaluated different modifications of Fe3O4 nanoparticles and found that Fe3O4@PEI MNPs were the most efficient nano sorbents for DNA extraction. Additionally, optimizing the composition of the extraction buffer improved the accuracy of DNA recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Biochemistry & Molecular Biology
Hyun-Min Yoon, Min-Su Kang, Go-Eun Choi, Young-Joon Kim, Chang-Hyu Bae, Young-Bob Yu, Young-IL Jeong
Summary: Stimuli-responsive nanoparticles, synthesized with glutathione and magnetic-sensitive nanocomposites, demonstrate dual-targeting strategy with redox-responsiveness and superior magnetic sensitivity. These nanoparticles exhibit high internalization efficiency in drug release and cell culture experiments, and in vivo studies show excellent anticancer drug targeting properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Abbas Vaezi-Kakhki, Ahmad Asoodeh
Summary: Iron oxide nanoparticles synthesized through different methods were evaluated for their antioxidant and cytotoxicity effects. Nanoparticles obtained through plant mediated synthesis showed the highest antioxidant activity and effectiveness in killing cancer cells. Green synthesis methods are environmentally friendly, cost-effective, and easy to perform.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Environmental Sciences
Mert Gurkan, Selin Erturk Gurkan, Sevdan Yilmaz, Mehmet Ates
Summary: This study investigated the toxic effects of alpha and gamma iron oxide nanoparticles on rainbow trout, including histopathological damages, iron accumulation, and oxidative stress. The findings suggest that both types of nanoparticles have the potential to cause toxicity in rainbow trout.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Jingfang Zhang, Zhenghan Di, Husheng Yan, Yuliang Zhao, Lele Li
Summary: A new study introduces a simple method for synthesizing Fe3O4 supraparticles for magnetic resonance imaging, showing potential for tumor imaging applications.
Article
Plant Sciences
Sidra Khan, Gulfam Bibi, Shazia Dilbar, Aneela Iqbal, Maaz Ahmad, Ahmad Ali, Zahid Ullah, Mariusz Jaremko, Javed Iqbal, Mohammad Ali, Ihtishamul Haq, Iftikhar Ali
Summary: The study confirmed the feasibility of synthesizing iron oxide nanoparticles using Mentha spicata and characterized the synthesized nanoparticles through various techniques. The nanobiotechnology-based iron oxide nanoparticles showed promising stability and antimicrobial properties in vitro.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Applied
Davide Dova, Silvia Cauteruccio, Norberto Manfredi, Stefan Prager, Andreas Dreuw, Serena Arnaboldi, Patrizia R. Mussini, Emanuela Licandro, Alessandro Abbott
Article
Biochemistry & Molecular Biology
Silvia Mercurio, Silvia Cauteruccio, Raoul Manenti, Simona Candiani, Giorgio Scari, Emanuela Licandro, Roberta Pennati
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Physical
Tommaso Taroni, Silvia Cauteruccio, Riccardo Vago, Stefano Franchi, Nadia Barbero, Emanuela Licandro, Silvia Ardizzone, Daniela Meroni
APPLIED SURFACE SCIENCE
(2020)
Article
Chemistry, Organic
Valentina Pelliccioli, Giuseppe Dilauro, Sara Grecchi, Serena Arnaboldi, Claudia Graiff, Filippo M. Perna, Paola Vitale, Emanuela Licandro, Alessandro Aliprandi, Silvia Cauteruccio, Vito Capriati
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Pramod Thakare, Francesca Vasile, Maura Vallaro, Sonja Visentin, Giulia Caron, Emanuela Licandro, Silvia Cauteruccio
Summary: The first comprehensive study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives was conducted, revealing that single nucleobases do not alter their pKa values when incorporated into PNA monomers and oligomers. Additionally, the PNA derivatives showed poor affinity towards membrane phospholipids and limited cell penetrating ability. The study has potential implications for evaluating the pharmacokinetic properties of PNA and for enhancing cell penetration properties through proper modification.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Materials Science, Multidisciplinary
Alberto Bossi, Serena Arnaboldi, Carlo Castellano, Rocco Martinazzo, Silvia Cauteruccio
ADVANCED OPTICAL MATERIALS
(2020)
Article
Chemistry, Organic
Valentina Pelliccioli, Davide Dova, Clara Baldoli, Claudia Graiff, Emanuela Licandro, Silvia Cauteruccio
Summary: Efficient and versatile synthetic routes to functionalized tetrathia[7]helicenes (7-THs) have been described in this study. Key intermediates were synthesized using palladium-catalyzed homocoupling reactions and annulation reactions. The versatility of bromides 1 for preparing a variety of 7-TH derivatives, including 7,8-disubstituted and 7-monosubstituted compounds, has been demonstrated.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Valentina Pelliccioli, Thierry Hartung, Martin Simon, Christopher Golz, Emanuela Licandro, Silvia Cauteruccio, Manuel Alcarazo
Summary: The study reports a highly enantioselective synthesis of 5,13-disubstituted dibenzo[d,d']benzo[1,2-b:4,3-b']dithiophenes, with the last two successive Au-catalyzed intra-molecular alkyne hydroarylation events being crucial for the successful assembly of these helical architectures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Valentina Pelliccioli, Francesca Cardano, Giacomo Renno, Francesca Vasile, Claudia Graiff, Giuseppe Mazzeo, Andrea Fin, Giovanna Longhi, Sergio Abbate, Alessia Rosetti, Claudio Villani, Guido Viscardi, Emanuela Licandro, Silvia Cauteruccio
Summary: This study reports the synthesis of a novel class of functionalized thia[6]helicenes and a thia[5]helicene, and investigates their configurational stability and photophysical properties. Experimental and theoretical studies confirmed the stability of selected thia[6]helicenes, while the pyrene-based thia[5]helicene was found to be unstable. The configuration assignment for one representative thiahelicene was established through the comparison between experimental and theoretical circular dichroism (CD) spectra.
Article
Chemistry, Organic
Nicolas D'Imperio, Valentina Pelliccioli, Sara Grecchi, Alberto Bossi, Francesca Vasile, Silvia Cauteruccio, Anna I. Arkhypchuk, Arvind Kumar Gupta, Andreas Orthaber, Sascha Ott, Emanuela Licandro
Summary: This paper describes the first examples of a pi-conjugated benzo[b]phosphole P-oxide, in which two phosphole P-oxide units are connected by a carbon-carbon double bond. The molecules exist as stable cis and trans isomers (chiral and meso one respectively) with respect to the two stereogenic P atoms. The optical and electrochemical properties of both isomers have been investigated through experiments and computations.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Alberto Bossi, Patrizia R. Mussini, Gianluca Farinola, Marta Penconi, Silvia Cauteruccio, Mark E. Thompson, Emanuela Licandro
Summary: In the thiahelicene family, selecting fluorine-containing groups can overcome the issue of structure-property correlations, and fluorine-functionalized tetrathia[7]helicenes were found to display green phosphorescence and efficient spin-orbit coupling mechanism in high-energy triplet nonplanar conjugated molecules.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Silvia Cauteruccio, Valentina Pelliccioli, Sara Grecchi, Roberto Cirilli, Emanuela Licandro, Serena Arnaboldi
Summary: In this study, a wireless miniaturized stereoselective light-emitting system was designed to qualitatively detect chiral contaminants in reduced volumes. By mixing an inherently chiral inductor with a chiral probe in micro-solutions of a commercial ionic liquid, an asymmetric environment was created. The synergy between the inductor, the applied electric field, and the chiral pollutant was transduced by the light emission produced from a miniaturized light-emitting diode (LED) used as a bipolar electrode.
Article
Materials Science, Biomaterials
Serena Riela, Ana Borrego-Sanchez, Silvia Cauteruccio, Raquel de Melo Barbosa, Marina Massaro, C. Ignacio Sainz-Diaz, Rita Sanchez-Espejo, Cesar Viseras-Iborra, Emanuela Licandro
Summary: This study systematically investigates the interaction between three differently charged PNAs and halloysite. Understanding the interaction mode between charged molecules and clay surfaces is crucial for the design and development of halloysite-based materials for the delivery and release of PNAs. The results show that PNAs interact with halloysite surfaces in different ways according to their charge, which affects their release in physiological conditions.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Valentina Pelliccioli, Roberta Franzini, Giuseppe Mazzeo, Claudio Villani, Sergio Abbate, Giovanna Longhi, Emanuela Licandro, Silvia Cauteruccio
Summary: This study investigated the stereochemical and chiroptical properties of a series of axially chiral intermediates, showing potential for developing chiral systems applicable in asymmetric synthesis, catalysis, and materials chemistry.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Serena Arnaboldi, Silvia Cauteruccio, Sara Grecchi, Tiziana Benincori, Massimo Marcaccio, Alessio Orbelli Biroli, Giovanna Longhi, Emanuela Licandro, Patrizia Romana Mussini
