Journal
ORGANIC LETTERS
Volume 16, Issue 1, Pages 142-145Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4031364
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Funding
- NIGMS [R01 GM100985-01]
- Princeton University
- Eli Lilly
- Amgen
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Quinolinium ions are engaged in an asymmetric, Ni-catalyzed Suzuki cross-coupling to yield 2-aryl- and 2-heteroaryl-1,2-dihydroquinolines. Key to the development of this method is the use of a Ni(II) precatalyst that activates without the need for strong reductants or high temperatures. The Ni-iminium activation mode is demonstrated as an exceptionally mild pathway to generate enantioenriched products from racemic starting materials.
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