Journal
ORGANIC LETTERS
Volume 14, Issue 11, Pages 2666-2669Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300589r
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Funding
- MOST [2010CB833800]
- NSFC [31070045, 31125001]
- CAS [KZCX2-YW-JC202, 08SL111002, KSCX2-EW-G-12]
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The biosynthetic gene cluster for caerulomycin A (1) was cloned and characterized from the marine actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, which revealed an unusual hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) system. The crmL disruption mutant accumulated caerulomycin L (2) with an extended L-leucine at C-7, implicating an amidohydrolase activity for CrmL. The leucine-removing activity was confirmed for crude CrmL enzymes. Heterologous expression of the 1 gene cluster led to 1 production in Streptomyces coelicolor.
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