Journal
ORGANIC LETTERS
Volume 14, Issue 8, Pages 2118-2121Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300657h
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Funding
- NIAID, NIH [RC4 AI092624]
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Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolido A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs).
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