Journal
ORGANIC LETTERS
Volume 14, Issue 7, Pages 1772-1775Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300017m
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Funding
- State Key Development Program of Basic Research of China [2009CB522300]
- Ministry of Education of China [NCET-10-0120]
- Key Sci-tech Research Projects of Guangdong Province [8351063201000003]
- Fundamental Research Funds for the Central Universities [21611203]
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Houltuynoids A-E (1-5), a new type of flavonoid with houttuynin tethered to hyperoside, and their presumed biosynthetic precursor hyperoside (6) were isolated from the whole plant of Houttuynia cordata. Their structures were elucidated by analysis of 10 and 20 NMR. A hypothetical biogenetic pathway for houttuynoids A-E was proposed. Compounds 1-5 exhibited potent anti-HSV (herpes simplex viruses) activity.
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