Article
Polymer Science
Yu-Ting Guo, Wei Xiong, Changxia Shi, Fu-Sheng Du, Zi-Chen Li
Summary: In this study, five eight-membered cyclic (ester-amide)s were synthesized and their organocatalytic ring-opening polymerization was investigated. The resulting polymers exhibited high thermal stability and side chain-dependent glass transition temperatures, and could be selectively degraded into monomer precursors in alkaline aqueous solutions.
Article
Polymer Science
Kangkang Li, Lei Cui, Yixin Zhang, Zhongbao Jian
Summary: The direct copolymerization of olefins with polar monomers to produce functionalized polyolefins, particularly those with amide functions, has been a challenge. However, by utilizing compounds with high ring strain and an amide moiety in ethylene copolymerization, high amide incorporation, molecular weights, and catalytic activities can be achieved. The resulting amide-functionalized polyethylenes can undergo facile post-transformations to produce polyethylenes with diverse functionalities, such as hydrogen bond-containing, difunctionalized, and water-soluble ammonium-functionalized polyethylenes, which exhibit antibacterial properties.
Review
Chemistry, Multidisciplinary
Max Lubberink, William Finnigan, Sabine L. Flitsch
Summary: Amide bonds are commonly formed in the pharmaceutical industry and there is a growing interest in biocatalytic methods for their synthesis. The use of low water systems and ATP-dependent enzymes have shown promise in driving amide bond formation. A publicly available database, RetroBioCat, has been compiled to provide literature on these methods.
Article
Chemistry, Multidisciplinary
Biao Yang, Kaifeng Niu, Felix Haag, Nan Cao, Junjie Zhang, Haiming Zhang, Qing Li, Francesco Allegretti, Jonas Bjork, Johannes Barth, Lifeng Chi
Summary: The study demonstrates the abiotic synthesis of amide bonds under ultra-high vacuum conditions on metal supports, showing a critical influence of the metal support on the reaction pathways.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Oliver W. M. Baldwin, Linden H. Conrad-Marut, Gregory L. Beutner, David A. Vosburg
Summary: A new undergraduate organic laboratory experiment has been developed for the synthesis of medicinally relevant amide products, which offers green chemistry aspects by selecting appropriate reagents and conditions. Through the process of experimentation and characterization, students gained insights into the reaction mechanism.
JOURNAL OF CHEMICAL EDUCATION
(2022)
Article
Nanoscience & Nanotechnology
Tianran Yan, Yu Wu, Fei Gong, Chen Cheng, Hao Yang, Jing Mao, Kehua Dai, Liang Cheng, Tao Cheng, Liang Zhang
Summary: This study utilizes sonication-assisted liquid-phase exfoliation to fabricate TiH2 nanodots as bifunctional electrocatalysts for lithium-sulfur batteries. The results show that TiH2 nanodots have a strong chemical affinity to polysulfides and can promote the precipitation and decomposition of Li2S, effectively suppressing shuttle effect and improving the redox kinetics of polysulfides.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Qimin Jiang, Liang Zhao, Yongzhuang Du, Wenyan Huang, Xiaoqiang Xue, Hongjun Yang, Li Jiang, Qilin Jiang, Bibiao Jiang
Summary: This study describes the one-pot synthesis of novel thermoresponsive nonconjugated fluorescent branched poly(ether amide)s and characterizes their structure and properties through a series of analysis methods. The results show that these polymers have a lower critical solution temperature and exhibit LCST-dependent fluorescent behavior within a specific temperature range. Moreover, these polymers demonstrate good biocompatibility and bright cell imaging capabilities.
Article
Chemistry, Organic
Shaofeng Li, Hanyu Nie, Mengyan Duan, Wenfei Wang, Congjun Zhu, Chuanjun Song
Summary: This work presents a strategy for the one-pot synthesis of protoberberine alkaloid derivatives using palladium catalyzed cascade alpha-arylation and cyclization, resulting in moderate to excellent isolated yields. The protocol provides an efficient and convenient path to multisubstituted protoberberine derivatives and can directly yield natural alkaloids.
Article
Chemistry, Applied
Sofia Strekalova, Alexander Kononov, Vladimir Morozov, Olga Babaeva, Elena Gavrilova, Yulia Budnikova
Summary: This study describes the electrochemical amidation of C(sp2)-H and C(sp3)-H bonds of a wide range of arenes using nitriles as amide sources, achieved under mild conditions without the need for metal catalysts or external oxidizing agents. The method offers moderate to high yields, can be applied to arenes with diverse functional groups, and is suitable for gram scale synthesis. The key role of the hydroxyl radical as an inductor generated during the oxidation of water has been established through EPR experiments.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Chemistry, Applied
Paola Acosta-Guzman, Andrea Ojeda-Porras, Diego Gamba-Sanchez
Summary: The construction of amide bonds is of great interest due to their prevalence in bioactive molecules. This review presents the most viable strategies for constructing amide bonds, with a focus on recent developments in the field.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Physical
Quan-Quan Zhou, You-Quan Zou, Sayan Kar, Yael Diskin-Posner, Yehoshoa Ben-David, David Milstein
Summary: A simple and efficient system utilizing a pincer complex of manganese has been developed for the hydration and alpha-deuteration of nitriles, providing amides, alpha-deuterated nitriles, and alpha-deuterated amides with good selectivity and moderate to good yields. The transformation proceeds through activation of nitriles via metal-ligand cooperation, generating key intermediates for further reactions.
Article
Chemistry, Organic
Amal Hassan Tolba, Martin Krupicka, Josef Chudoba, Radek Cibulka
Summary: The method utilizes riboflavin tetraacetate (RFTA) as an inexpensive organic photocatalyst, visible light, and oxygen as the sole oxidant to synthesize tertiary amides through the oxidative coupling of aromatic or aliphatic aldehydes with amines. The reaction is based on the oxidative power of an excited flavin catalyst and the relatively low oxidation potential of the hemiaminal formed by amine to aldehyde addition.
Article
Chemistry, Organic
Mhairi Boyle, Keith Livingstone, Martyn C. Henry, Jessica M. L. Elwood, J. Daniel Lopez-Fernandez, Craig Jamieson
Summary: The rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides can be used for the facile construction of amide bonds, with broad applicability to the synthesis of primary, secondary, and tertiary amides. This method demonstrates orthogonality and functional group tolerance, as shown by the N-acylation of unprotected amino acids.
Article
Chemistry, Organic
Yue Chen, Dong-mei Fang, He-sen Huang, Xiao-kang Nie, Shi-qi Zhang, Xin Cui, Zhuo Tang, Guang-xun Li
Summary: A mild and simplified method for preparing sulfilimines via selective S-C bond formation instead of traditional S-N bond formation is developed. This method is attractive because it uses readily available alkyl bromide or alkyl iodide as alkylation reagents, water as solvent, is easy to perform, and convenient for late-stage diversification of drugs.
Article
Polymer Science
Guohang He, Qingyi Lu, Feng Xu, Dongkui Zhang, Ying Li, Jiangbin Xia
Summary: This article presents the rational design and investigation of several 3,5-dibromo substituted BODIPY derivatives as potential candidates for solid state polymerization (SSP). The study successfully expands SSP to the BODIPY system and provides crystallographic data to analyze the reasonable path of SSP and explore its mechanism. Additionally, the relationship between fluorescence intensity of BODIPY after SSP and temperature is established, opening up possibilities for its application in temperature fluorescence sensors with high sensitivity.
Article
Chemistry, Medicinal
Zhengrui Miao, Julie A. Reisz, Susan M. Mitroka, Jia Pan, Ming Xian, S. Bruce King
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Chemistry, Organic
Jia Pan, Kate S. Carroll
Article
Endocrinology & Metabolism
Archita Agrawal, Sebastian Parlee, Diego Perez-Tilve, Pengyun Li, Jia Pan, Piotr A. Mroz, Ann Maria Kruse Hansen, Birgitte Andersen, Brian Finan, Alexei Kharitonenkov, Richard D. DiMarchi
MOLECULAR METABOLISM
(2018)
Article
Biochemistry & Molecular Biology
Jia Pan, Kate S. Carroll
ACS CHEMICAL BIOLOGY
(2013)
Article
Chemistry, Multidisciplinary
Dehui Zhang, Igor Macinkovic, Nelmi O. Devarie-Baez, Jia Pan, Chung-Min Park, Kate S. Carroll, Milos R. Filipovic, Ming Xian
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2014)
Review
Biochemistry & Molecular Biology
Jia Pan, Kate S. Carroll
Article
Chemistry, Multidisciplinary
Jia Pan, Ming Xian
CHEMICAL COMMUNICATIONS
(2011)
Article
Biochemistry & Molecular Biology
Jia Pan, Jonathan A. Downing, Jeanne L. McHale, Ming Xian
MOLECULAR BIOSYSTEMS
(2009)
Article
Chemistry, Organic
Dehui Zhang, Nelmi O. Devarie-Baez, Jia Pan, Hua Wang, Ming Xian
Review
Biochemistry & Molecular Biology
Rongjun He, Jia Pan, John P. Mayer, Fa Liu
Review
Chemistry, Organic
Rongjun He, Jia Pan, John P. Mayer, Fa Liu
CURRENT ORGANIC CHEMISTRY
(2019)
