Review
Nutrition & Dietetics
Marianna Minnetti, Valentina Sada, Tiziana Feola, Elisa Giannetta, Carlotta Pozza, Daniele Gianfrilli, Andrea M. Isidori, Alessia Cozzolino
Summary: Selenium is an essential trace element that plays a crucial role in thyroid metabolism and the immune system. Supplementing with selenium may improve inflammation in patients with thyroiditis and potentially affect thyroid function during pregnancy. However, further research is needed to confirm the effectiveness of selenium supplementation in pregnant women with thyroiditis.
Review
Nutrition & Dietetics
Yong-Sheng Wang, Shan-Shan Liang, Jun-Jie Ren, Zi-Yi Wang, Xin-Xin Deng, Wen-Di Liu, Yi-Long Yan, Gui-Hang Song, Xiu-Xia Li
Summary: This research assessed the effects of selenium supplementation in the treatment of autoimmune thyroiditis (AIT) and found that selenium supplementation might reduce TPO-Ab and Tg-Ab levels in the non-LT4-treated population, but the certainty of evidence was low.
Article
Medicine, General & Internal
Rossella Cannarella, Rosita A. Condorelli, Aldo E. Calogero, Vincenzo Bagnara, Antonio Aversa, Emanuela A. Greco, Antonio Brunetti, Sandro La Vignera
Summary: The study evaluated the effects of oral Se supplementation on conventional sperm parameters and DNA fragmentation in patients with AT of reproductive age with normal thyroid function. Results showed that after Se supplementation, patients had improved sperm parameters and reduced DNA fragmentation, suggesting that Se supplementation may be a potential therapeutic option for male infertility. Further studies are needed to confirm these findings and clarify the potential thyroid hormone dependency.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Wei Wang, Qi-Lan Jiang, Qin Xu, Yang Zeng, Rui Jiang, Jun Jiang
Summary: Selenium supplementation has the potential to improve the prognosis of autoimmune thyroiditis (AIT) by altering the subset differentiation and/or function of CD4+ T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Fan Li, Zheng Zhou, Lingbo Wang, Baoxiang Li, Meihui Jin, Jinjin Liu, Yun Chen, Yanhong He, Bingxuan Ren, Hongmei Shen, Lixiang Liu
Summary: Excess iodine triggers autoimmune thyroiditis (AIT), while programmed death-1 (PD-1)/programmed death ligand (PD-L) also contribute to AIT development. This study aimed to explore the role of negative regulatory signals mediated by PD-1/PD-L in spontaneous autoimmune thyroiditis (SAT) development in NOD.H-2h4 mice exposed to iodine. NOD.H-2h4 mice were administered intraperitoneal PD-L1 antibody. Various indicators were determined, and results showed increased urinary iodine level, thyroid lymphocyte infiltration, thyroglobulin antibodies (TgAb), interferon (IFN-γ)/tumor necrosis factor (TNF-α)/interleukin (IL-2)/IL-17 levels, and expression of PD-1/PD-L1/programmed death-2 (PD-L2) with excess iodine intervention. Inhibition of PD-1/PD-L1/PD-L2 expression, however, did not decrease thyroid lymphocyte infiltration and serum TgAb/IFN-γ/TNF-α/IL-2/IL-17 levels. Further research is needed to determine if PD-1/PD-L intervention can effectively treat autoimmune thyroid disease.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Na Zhao, Zhenzhen Wang, Xuejiao Cui, Shuo Wang, Chenling Fan, Yushu Li, Zhongyan Shan, Weiping Teng
Summary: This study confirmed the involvement of miR-326 in regulating Th17/Treg balance in autoimmune thyroiditis using lentiviral gene delivery. MiR-326 targeted therapy shows promising results in the treatment of AIT, and tail vein injection may achieve a better intervention effect than thyroid injection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Jadwiga Kryczyk-Koziol, Ewelina Prochownik, Anna Blazewska-Gruszczyk, Marian Slowiaczek, Qian Sun, Lutz Schomburg, Ewa Ochab, Miroslaw Bartyzel, Pawel Zagrodzki
Summary: The impact of selenium on the course of Hashimoto's thyroiditis (HT) was assessed by monitoring the titer of antithyroid autoantibodies, while the imbalance in T cell activity and changes in cytokine secretion were also examined. Selenium supplementation was found to affect the production of interferon gamma and interleukin 1 beta. The study revealed interdependent factors shaping the cytokine profile in HT, including the stage of disease development, degree of thyroid dysfunction, and selenium supplementation.
Article
Endocrinology & Metabolism
Yuxuan Qiu, Zhichao Xing, Qiao Xiang, Qianru Yang, Jingqiang Zhu, Anping Su
Summary: This study critically evaluated the clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis (AIT), finding that while selenium may reduce autoantibody levels in some patients, it also increases the risk of adverse effects. Therefore, the current evidence does not support the widespread use of selenium supplementation for the treatment of AIT.
Article
Biochemistry & Molecular Biology
Zhen-Nan Wang, Hui Li, He Tang, Shu-Jiu Zhang, Mirielle Pauline, Chong-Liang Bi
Summary: The study showed that increased dietary selenium supplementation could enhance selenium deposition and antioxidant enzyme activity in mouse serum, liver, and mammary gland while decreasing MDA concentration. The results suggested that selenium was mainly deposited in the liver, and dietary selenium during pregnancy might improve the antioxidant status in postpartum animals.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Nutrition & Dietetics
Dorota Filipowicz, Ewelina Szczepanek-Parulska, Malgorzata Klobus, Krzysztof Szymanowski, Thilo Samson Chillon, Sabrina Asaad, Qian Sun, Aniceta A. Mikulska-Sauermann, Marta Karazniewicz-Lada, Franciszek K. Glowka, Dominika Wietrzyk, Lutz Schomburg, Marek Ruchala
Summary: The demand for selenium increases during pregnancy, but in areas with limited selenium supply, most pregnant women have insufficient selenium status. Maternal selenium deficiency is transferred to newborns, indicating the need for re-evaluation of micronutrient monitoring and guidance in pregnancy care.
Review
Endocrinology & Metabolism
Dorota Filipowicz, Karolina Majewska, Anastasia Kalantarova, Ewelina Szczepanek-Parulska, Marek Ruchala
Summary: Selenium (Se) supplementation is commonly prescribed to autoimmune thyroiditis (AIT) patients in Europe, despite the lack of official guidelines. Proper intake of Se can have beneficial effects on thyroid function and overall health, but excessive or inadequate intake should be avoided. The supplementation of Se should be tailored to individual needs and clinical situations to maximize its benefits while minimizing potential risks.
ENDOKRYNOLOGIA POLSKA
(2021)
Review
Immunology
Qian Zhu, Qian-Han Xu, Ting Xie, Li-Ling Wang, Hong Liu, Kahindo P. Muyayalo, Xiao-Bo Huang, Si-Jia Zhao, Ai-Hua Liao
Summary: Autoimmune thyroiditis (AIT) is associated with adverse reproductive outcomes, potentially due to abnormal changes in the maternal immune system and maternal-fetal interface. Dysfunctions in both humoral and cellular immunity may contribute to infertility, miscarriage, and preterm birth in women with AIT.
CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jadwiga Kryczyk-Koziol, Pawel Zagrodzki, Pawel Pasko
Summary: The relationship between selenium and autoimmune thyroiditis is not fully understood, and further research is needed to clarify its mechanisms. Supplementation of selenium may help in treating the disease more effectively by reducing the concentration of anti-TPO, but the overall results from studies are inconclusive.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2021)
Article
Horticulture
Luca Regni, Carlo Alberto Palmerini, Alberto Marco Del Pino, Daniela Businelli, Roberto D'Amato, Hanene Mairech, Fabio Marmottini, Maurizio Micheli, Pablo H. Pacheco, Primo Proietti
Summary: This study found that treating olive trees with selenium in hydroponic culture can improve their resistance to salt stress, promote the balance of key bio-molecules like proline, selenium, and Ca2+, thus enhancing plant growth indices and mitigating the negative effects of salt stress.
SCIENTIA HORTICULTURAE
(2021)
Article
Medicine, Research & Experimental
Xihua Yang, Lixia Chen, Lili Zhao, Yongming Yang, Jing Wang, Lei Yan, Gang Tai, Hong Zhang
Summary: The study aimed to investigate the therapeutic effect of Isaria felina on experimental autoimmune thyroiditis (EAT). The results showed that high-dose Isaria felina treatment significantly reduced circulating TSH, thyroid antibody, and cytokine levels in EAT mice. In addition, high-dose Isaria felina alleviated histopathological abnormalities and attenuated cell apoptosis in the thyroid tissue samples.
BIOMEDICINE & PHARMACOTHERAPY
(2021)