4.8 Article

Potassium Hydroxide/Dimethyl Sulfoxide Promoted Intramolecular Cyclization for the Synthesis of Benzimidazol-2-ones

Journal

ORGANIC LETTERS
Volume 13, Issue 11, Pages 2876-2879

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2008878

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Funding

  1. Fonds der Chemischen Industrie

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A new protocol for intramolecular N-arylations of ureas to form benzimidazol-2-ones has been developed. The cyclization reaction occurs In the presence of KOH and DMSO at close to ambient temperature. Under these conditions the yields are high and a wide range of functional groups are tolerated.

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