Journal
ORGANIC LETTERS
Volume 13, Issue 17, Pages 4624-4627Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2018449
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Funding
- Bloomington Stock Center
- Drosophila Genetic Resource Center at the Kyoto Institute of Technology
- Genetic Strain Research Center of the National Institute of Genetics for the fly stocks
- Ministry of Education, Science, Sports and Culture of Japan [21249004, 21117005, 21310134, 21710215]
- Uehara Memorial Foundation
- Takeda Science Foundation
- Mitsubishi Foundation
- Program for Promotion of Basic Research Activities for Innovative BioSciences
- Grants-in-Aid for Scientific Research [21117005, 23710247, 21710215, 21249004, 21310134, 21117001] Funding Source: KAKEN
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Innate Immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an Innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-alpha-stimulated production of IL-8 in human umbilical vein endothelial cells.
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