4.8 Article

Catalytic Enantioselective Conjugate Allylation of Unsaturated Methylidene Ketones

Journal

ORGANIC LETTERS
Volume 13, Issue 5, Pages 995-997

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol102982b

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Funding

  1. NIH [NIGMS GM-64451]
  2. LaMattina
  3. Schering-Plough

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The use of unsaturated methylidene ketones in catalytic conjugate allylations allows a significant expansion in substrate scope and, with appropriate chiral ligands, occurs in a highly enantioselective fashion.

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