Journal
ORGANIC LETTERS
Volume 13, Issue 23, Pages 6224-6227Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol202679t
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Funding
- National Science Foundation [CHE-0911264]
- Research Corporation for Science Advancement
- Arnold and Mabel Beckman Foundation
- American Chemical Society
- Calvin College
- Michigan State University
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A new method for the synthesis of,beta-iodo N-alkenyl 2-pyridones from substituted 2-propargyloxypyridines has been discovered. These compounds present a unique complement of orthogonal functionality and structural characteristics that are unavailable via other routes. The ready access to these compounds renders them an important entry point for the preparation of more complex N-alkyl pyricione-containing targets.
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