4.8 Article

Construction of Highly Functional Quaternary Carbon Stereocenters via an Organocatalytic Tandem Cyanation-Allylic Alkylation Reaction

Journal

ORGANIC LETTERS
Volume 13, Issue 23, Pages 6164-6167

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202499g

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Funding

  1. NSFC [21102054]
  2. Jilin University (China)

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The first tertiary amine-catalyzed tandem cyanation-allyic alkylation (CAA) reaction of aldehydes, appropriate cyanide sources, and Morita-Baylis-Hillman (MBH) adducts has been developed, which provides a facile access to densely functionalized products containing O-substituted quaternary centers.

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